Recombinant Human 3',5'-cyclic-AMP phosphodiesterase 4D (PDE4D DPDE3)

1. PDE4D polymorphism is associated with Gastric and esophageal cancer. PMID: 30202044
2. In Pseudohypoparathyroidism, mutations were found in PRKAR1A, PDE4D, TRPS1, and PTHLH. PMID: 29499646
3. TT genotype of SNP87 in PDE4D was associated with an increased risk for 3-month unfavorable outcome after total ischemic stroke, as well as stroke due to large-artery atherosclerosis and small-artery occlusion, in a Chinese population. PMID: 28225001
4. SNP 83 of PDE4D gene may increase the risk for developing ischemic stroke whereas SNP 87 and SNP45 of PDE4D may not be associated with the risk of ischemic stroke in the North Indian population PMID: 28562233
5. Results provide new information concerning the mechanism whereby the mutations identified in the ACRDYS2 dysregulate PDE4D activity, and give insights into rare diseases involving the cAMP signaling pathway. PMID: 29016851
6. This supports PDE4D5 and RACK1 as potential regulators of cell adhesion, spreading and migration through the non-classical exchange protein activated by cyclic AMP (EPAC1)/Rap1 signalling route PMID: 28069443
7. PDE4D isoform composition is altered in localized prostate cancer and it can be used both as a diagnostic as well as a prognostic biomarker. PMID: 27683107
8. Genetic analysis identified the identical, novel heterozygous missense mutation of the PDE4D gene c.569C>T (p.Ser190Phe) in two patients in same family. This case illustrates the significant phenotypic variability of acrodysostosis even within one family with identical mutations. PMID: 28515031
9. The key residues involved in the interaction with a number of in-house catechol iminoether derivatives, acting as PDE4DIs. PMID: 27546041
10. Screening of PRKAR1A and PDE4D in a Large Italian Series of Patients Clinically Diagnosed With Albright Hereditary Osteodystrophy and/or Pseudohypoparathyroidism PMID: 26763073
11. p53 induced the transcription of miR-139-5p, which in turn suppressed the protein levels of phosphodiesterase 4D (PDE4D), an oncogenic protein involved in multiple tumor promoting processes. PMID: 27383270
12. High PDE4D expression is associated with melanoma. PMID: 28092671
13. cells on fibronectin suppressed cAMP via enhanced phosphodiesterase (PDE) activity, through direct binding of integrin alpha5 to phosphodiesterase-4D5 PMID: 27595237
14. we performed a meta-analysis of 15 studies, involving 8731 IS patients and 10,756 controls. The results showed nonsignificant association between PDE4D SNP56 and IS risk (T vs. A: OR=1.01, 95%CI=0.88-1.15, P=0.90). Similarly, in the subgroup analysis by ethnicity, no significant association was observed in Asian (T vs. A: OR=1.08, 95%CI=0.80-1.44, P=0.62) or European (T vs. A: OR=0.96, 95%CI=0.86-1.08, P=0.54) population. PMID: 27759001
15. Results support an important association of rs966221 and rs12188950 minor allele and its interaction with increased risk of ischemic stroke risk, and additional interaction between rs966221 and smoking PMID: 28191858
16. RACK1 and beta-arrestin2 inhibit the dimerization of PDE4D5. PMID: 26257302
17. PDE4D acts to allow cAMP-elevating agents to regulate VECADs' role as a sensor of flow-associated fluid shear stress (FSS)-encoded information in arterial endothelial cells. PMID: 26658094
18. PDE4D gene polymorphisms influence the susceptibility for the development of Sudden Sensorineural Hearing Loss in the southern Taiwanese female population. PMID: 26521189
19. focus on recent progress made in PDE4D gene research involving genetic and molecular aspects (review) PMID: 26004910
20. No association was found between single-nucleotide polymorphisms of ALOX5AP or PDE4D and the risk of overall ischemic stroke in a southeastern Chinese population. PMID: 24485247
21. While prior studies have found an association between PDE4D and IL6R polymorphisms and ischemic stroke, the results of this study suggest that this association may be different in a hypertensive population. PMID: 26782593
22. This review show PDE4D mutation is a risk factor for atrial fibrillation and stroke. PMID: 26671126
23. In this article, we review the role of the cAMP signal transduction pathway in memory formation with a particular focus on the recent progress in PDE4D research PMID: 26211680
24. Aberrant DNA methylation of PDE4D promoter alters airway smooth muscle cell phenotypes. PMID: 26181301
25. PDE4D interacts directly with Neuropilins, positive regulators of Hedgehog signal transduction pathway. PMID: 26371509
26. results suggest that the rs918592 and rs2910829 polymorphisms and haplotypes of PDE4D gene are significantly associated with ischemic stroke in Chinese young population. PMID: 23466835
27. The increase in the C allele frequency at 87 single nucleotide polymorphism sites in PDE4D may increase ischemic stroke risk. PMID: 26345966
28. Data highlight an increase in PDE4D7 expression during initial tumorigenesis and further support the findings that PDE4D7 levels fall profoundly in castration resistant prostate cancer, suggesting it as a potential biomarker and therapeutic target. PMID: 26575822
29. Critical residues stabilising PDE4D5 dimerization were defined within the regulatory UCR1 region found in long, but not short, PDE4 isoforms, namely the Arg(173), Asn(174) and Asn(175) (DD1) cluster. PMID: 25546709
30. These studies suggest the pharmacologic inhibition of PDE4D using small-molecule inhibitors is an effective option for prostate cancer therapy. PMID: 25149359
31. This result supports that PDE4D polymorphisms might be involved in the susceptibility to COPD especially in non-emphysematous individuals and that they could also affect the responsiveness of the PDE4 inhibitor treatment. PMID: 24926854
32. structural analysis of the autoinhibited conformation of PDE4 PMID: 25775568
33. The knockdown of PDE4D gene expression inhibited proliferation of STK11-mutated lung cancer lines. Furthermore, challenge with a panel of PDE4-specific inhibitors was shown to selectively reduce the growth of STK11-mutated lung cancer lines. PMID: 25122068
34. specific inhibitory PDE4D mutations can lead to the molecular pathology of acrodysostosis without hormone resistance but that the pathological phenotype may well be dependent on an over-compensatory induction of other PDE4 isoforms PMID: 25064455
35. PDE3A1 and PDE4D3 are integrated into complexes that contain the 5-HT4(b) receptor and may thereby regulate 5-HT4(b) receptor-mediated signaling. PMID: 25101859
36. PKA phosphorylation of the PDE4D7 N-terminus appears to occur constitutively and inhibits PDE4 activity to allow cAMP signalling under basal conditions. PMID: 25680530
37. This study found an association between SNP83 and ischemic stroke in the overall population and in the Asian and Chinese populations, but not among Caucasians. PMID: 24365247
38. haploinsufficiency of PDE4D results in a novel intellectual disability syndrome, the 5q12.1-haploinsufficiency syndrome, with several opposing features compared with acrodysostosis that is caused by dominant negative mutations. PMID: 24203977
39. Patients with the C/C genotype of SNP 83 exhibited significantly more cognitive dysfunction at 1 day (29.7%) than the C/T (15.8%, P = .008) and T/T (12.7%, P = .01) genotypes. PMID: 23863764
40. Multiple factors contribute to the pathogenesis of nasal polyps including genetic predisposition. The PDE4D family has gained interest in the complex pathogenesis of nasal polyposis. This is likely linked to the mucosal inflammatory response. PMID: 24142618
41. results suggest that SNP 83 in PDE4D gene is significantly associated with susceptibility to ischemic stroke in Chinese population PMID: 23799094
42. PDE4D gene variants 83 and 87 did not show any significant association with coronaary heart disease, but may indirectly associate with risk agents of CHD> PMID: 23852788
43. research analyzed association of rs702553 with baseline mean arterial blood pressure in a subset of the African American Study of Kidney Disease and Hypertension Cohort; compared with participants with AA/AT genotypes, those with a TT genotype at rs702553 had significantly lower baseline MAP among study participants on a diuretic PMID: 23778321
44. Comparative analysis of the binding responses of mutations to mAKAP could provide important information about how these mutations modulate PKA and PDE4D3 signaling. PMID: 23806656
45. PDE4D5-beta-arrestin2 complex allowed the recruitment of Epac1 to beta2AR and induced a switch from beta2AR non-hypertrophic signaling to a beta1AR-like pro-hypertrophic signaling cascade. PMID: 23266473
46. although targeted by genomic homozygous microdeletions, PDE4D functions as a tumor-promoting factor and represents a unique targetable enzyme of cancer cells PMID: 23536305
47. An increased frequency of phosphodiesterase 4D TT genotype is associated with risk of myocardial infarction in men over 60 years old. PMID: 23786009
48. Data indicate that missense mutations were identified in all acrodysostosis patients. PMID: 23033274
49. Single nucleotide polymorphisms in PDE4D is associated with response to antipsychotic agents in schizophrenia. PMID: 23241943
50. Data indicate that single-nucleotide polymorphisms (SNPs) in 5-lipoxygenase activating protein (ALOX5AP), phosphodiesterase 4D (PDE4D), and interleukin-1alpha (IL-1alpha) were associated with an increased risk of atherothrombotic stroke (ATS) in Chinese. PMID: 23076369

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HGNC: 8783

OMIM: 600129

KEGG: hsa:5144

STRING: 9606.ENSP00000345502

UniGene: Hs.117545