Code | CSB-RA996952A0HU |
Size | US$210 |
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Application | Recommended Dilution |
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WB | 1:500-1:5000 |
PDE4 cyclic nucleotide phosphodiesterases reduce 3′, 5′ cAMP levels in the central nervous system (CNS) and thereby regulate PKA activity and the phosphorylation of CREB, fundamental to depression, cognition, and learning and memory. Mutations in PDE4D in humans predispose to acrodysostosis, associated with cognitive and behavioral deficits. PDE4D gene inactivation in mice results in progressive cardiomyopathy, accelerated heart failure after myocardial infarction, and cardiac arrhythmias. PDE4D also plays a role in the regulation of vascular permeability.
The production of this recombinant PDE4D antibody started with immunization. And then the workflow included B cell harvest and enrichment; import single B cell; assays to identify the specificity, affinity & functionality of the cell; export the single B cell; cDNA synthesis and sequencing; express the PDE4D antibody in mammalian cells. The target PDE4D antibody was validated in ELISA, WB.There are currently no reviews for this product.