Recombinant Human ATP-binding cassette sub-family A member 13(ABCA13) ,partial

Code CSB-YP771437HU
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Source Yeast
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Code CSB-EP771437HU
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Source E.coli
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Code CSB-EP771437HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP771437HU
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Source Baculovirus
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Code CSB-MP771437HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names ABCA13
Uniprot No. Q86UQ4
Alternative Names Abca13; ABCAD_HUMAN; ATP-binding cassette sub-family A member 13; FLJ33876; FLJ33951
Species Homo sapiens (Human)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
May mediate the cholesterol and gangliosides transport from the plasma membrane to intracellular vesicles in an ATP hydrolysis dependent manner, thus playing a role in their internalization by endocytic retrograde transport and may also participate in the endocytosis of synaptic vesicle in cortical neurons.
Gene References into Functions
  1. ABCA13 gene may contain overlapping common genetic risk factors for both major depressive disorder and schizophrenia in the Han Chinese population. PMID: 27712136
  2. Rare missense variants within a single gene, abca13, form yin yang haplotypes. PMID: 25898927
  3. The results of this study demonstrated that common genetic variants at ABCA13 are unlikely to be related to the pathogenesis of schizophrenia in the Han Chinese population. PMID: 23910238
  4. No copy number variation including ABCA13 was identified in schizophrenia, bipolar disorder, or major depressive disorder samples, nor in the controls. PMID: 23250005
  5. An alternative human ABCA13 transcript and protein. PMID: 23266639
  6. ABCA13 is a candidate gene in schizophrenia, bipolar disorder, and depression PMID: 19944402
  7. Description of a new gene that maps to chromosome 7. PMID: 12697998

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Subcellular Location Cytoplasmic vesicle membrane; Multi-pass membrane protein.
Protein Families ABC transporter superfamily
Tissue Specificity Significantly expressed in the bone marrow, trachea, testis, thyroid and lung as well as in skin fibroblasts.
Database Links

HGNC: 14638

OMIM: 607807

KEGG: hsa:154664

STRING: 9606.ENSP00000411096

UniGene: Hs.226568

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