Product Details

Purity

Greater than 90% as determined by SDS-PAGE.

Target Names

ACRV1

Uniprot No.

P26436

Research Area

Signal Transduction

Alternative Names

Acrosomal protein SP 10; Acrosomal protein SP-10; Acrosomal vesicle protein 1; ACRV1; ASPX_HUMAN; D11S4365; Msa63; SP 10; Sp10; SPACA2; Sperm protein 10

Species

Homo sapiens (Human)

Source

E.coli

Expression Region

22-265aa

Target Protein Sequence

QPNELSGSIDHQTSVQQLPGEFFSLENPSDAEALYETSSGLNTLSEHGSSEHGSSKHTVAEHTSGEHAESEHASGEPAATEHAEGEHTVGEQPSGEQPSGEHLSGEQPLSELESGEQPSDEQPSGEHGSGEQPSGEQASGEQPSGEHASGEQASGAPISSTSTGTILNCYTCAYMNDQGKCLRGEGTCITQNSQQCMLKKIFEGGKLQFMVQGCENMCPSMNLFSHGTRMQIICCRNQSFCNKI
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Mol. Weight

41.8kDa

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal 6xHis-SUMO-tagged

Form

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

3-7 business days

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet & COA

Please contact us to get it.

Description

The expression region of this recombinant Human ACRV1 covers amino acids 22-265. The calculated molecular weight for this ACRV1 protein is 41.8 kDa. This protein is generated in a e.coli-based system. The N-terminal 6xHis-SUMO tag was fused into the coding gene segment of ACRV1, making it easier to detect and purify the ACRV1 recombinant protein in the later stages of expression and purification.

Acrosomal protein SP-10 (ACRV1) is primarily associated with research in the field of male reproduction. One of its most crucial research directions involves its function in germ cell development and sperm maturation processes. SP-10 is a key protein during sperm maturation, present in the acrosome of sperm, a structure critical in the fertilization process. Researchers focus on understanding the exact functions of SP-10 in sperm formation, motility, and fertilization to gain insights into its contributions to reproductive health. SP-10 is linked to issues with male fertility, including difficulties in achieving pregnancy and lower fertility rates. This has attracted significant attention in the fields of reproductive medicine and andrology research.

Target Background

Gene References into Functions

ACRV1 protein was predominantly located in round and elongated spermatids in testes, indicating that ACRV1 may play an important role in mammalian spermatogenesis PMID: 21488928

Subcellular Location

Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Nascent acrosomal vesicle of Golgi phase spermatids.

Tissue Specificity

Testis.

Database Links

HGNC: 127

OMIM: 102525

KEGG: hsa:56

STRING: 9606.ENSP00000432816

UniGene: Hs.169222

Code	CSB-EP001186HU
Abbreviation	Recombinant Human ACRV1 protein
MSDS	MSDS Datasheet
Size	$224
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Image	(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Recombinant Human Acrosomal protein SP-10 (ACRV1)

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