Recombinant Human Actin filament-associated protein 1-like 2 (AFAP1L2), partial

1. present study demonstrated that the expression of XB130 is elevated in CRC cells. Loss of XB130 was associated with decreased invasion and migration of CRC cells, possibly as a result of EMT inhibition. PMID: 28849225
2. Our results suggest that dissociation between XB130 and Tks5 may facilitate lateral cell migration via XB130/Rac1, and vertical cell migration via Tks5/Cdc42. These molecular mechanisms will help our understanding of airway epithelial repair and regeneration. PMID: 27835612
3. these observations suggest that XB130 may be a novel molecular marker and potent therapeutic target for prostate PMID: 27509056
4. Results suggest that Tks5, similar to XB130, plays a role in cell proliferation and cell survival and that the interaction between XB130 and Tks5 appears to be critical for regulation of Src-mediated cellular homeostasis. PMID: 26446840
5. XB130 is a mediator for nicotine-derived nitrosamine ketone-induced cell migration through its translocation to cell motility related microfilamentous cellular structures. PMID: 25980441
6. XB130 could be useful as a prognostic marker of recurrence-free and overall survival in invasive ductal breast cancer, as well as for the response to chemotherapy. PMID: 26191231
7. This is the first study to reveal that XB130 overexpression may be related to the prediction of metastasis potency and poor prognosis for osteosarcoma patients PMID: 26045762
8. Results showed significant interaction between variants at TERF1 and AFAP1L2 loci. Given the key role of TERF1 in telomere biology and its physical interaction with AFAP1L2, these results support a role for telomere dysfunction in melanoma development. PMID: 25892537
9. High XB130 expression is associated with pancreatic ductal adenocarcinoma. PMID: 24581082
10. XB130 enhances cell motility and invasiveness by modulating the epithelial-mesenchymal transition-like process. PMID: 24387290
11. High nuclear expression of XB130 is associated with esophageal squamous cell carcinoma. PMID: 22805860
12. XB130 could promote growth of cancer cells by regulating expression of tumor suppressive miRNAs and their targeted genes. PMID: 23527086
13. XB130 is a substrate of multiple protein tyrosine kinases, and it can regulate cell proliferation and survival through modulating selected down-stream signals of PI3K/Akt pathway PMID: 22928011
14. reduced XB130 protein expression is a prognostic biomarker for shorter survival and a higher recurrence rate in patients with gastric cancer PMID: 22927913
15. Protein expression of XB130 is not associated with the postoperative prognosis of patients with hepatocellular carcinoma. PMID: 22190283
16. These observations suggest that the expression of XB130 in these cancer cells may affect cell proliferation and survival by controlling the expression of multiple genes, especially transcription regulators. PMID: 21224076

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HGNC: 25901

OMIM: 612420

KEGG: hsa:84632

STRING: 9606.ENSP00000303042

UniGene: Hs.501106