Recombinant Human Aldehyde dehydrogenase family 1 member A3(ALDH1A3)

Code CSB-YP001567HU
Product Type Recombinant Protein
Size US$2010
Uniprot No. P47895
Relevance Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Storage Buffer Tris-based buffer,50% glycerol
Alias Aldehyde dehydrogenase 6 Retinaldehyde dehydrogenase 3 Short name:RALDH-3 Short name:RalDH3
Species Homo sapiens (Human)
Purity Greater than 90% as determined by SDS-PAGE.
Sequence ATANGAVENGQPDRKPPALPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNPSTREQICEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGFKMSGNGRELGEYALAEYTEVKTVTIKLGDKNP
Research Area Others
Source Yeast
Gene Names ALDH1A3
Protein Names Recommended name: Aldehyde dehydrogenase family 1 member A3 EC= 1.2.1.5 Alternative name(s): Aldehyde dehydrogenase 6 Retinaldehyde dehydrogenase 3 Short name= RALDH-3 Short name= RalDH3
Expression Region 2-512aa
Tag Info N-terminal 6xHis-tagged
Mol. Weight 58.0kDa
Protein Description Full Length of Mature Protein
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function NAD-dependent aldehyde dehydrogenase that catalyzes the formation of retinoic acid
Involvement in disease Microphthalmia, isolated, 8 (MCOP8)
Subcellular Location Cytoplasm
Protein Families Aldehyde dehydrogenase family
Tissue Specificity Expressed at low levels in many tissues and at higher levels in salivary gland, stomach, and kidney.
Database Links

HGNC: 409

OMIM: 600463

KEGG: hsa:220

STRING: 9606.ENSP00000332256

UniGene: Hs.459538

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