Recombinant Human Alpha-adducin (ADD1)

1. alpha-adducing SNPs were not associated with bone density among lead workers. PMID: 29028685
2. These findings highlight that ADD1 methylation may have a contributing role in the pathogenesis of EH with varying implications for both genders. PMID: 28686109
3. The ADD1 Gly460Trp gene polymorphism is significantly and independently associated with Essential Hypertension risk in a Caucasian population from Madeira Island. PMID: 29049185
4. ZNF322A overexpression transcriptionally dysregulates genes involved in cell growth and motility therefore contributes to lung tumorigenesis and poor prognosis PMID: 26279304
5. ADD1 rs4963 polymorphism showed an increased hypertension risk. PMID: 28040068
6. This indicates that ADD1 G460W polymorphism could be an important factor in the pathophysiology of tinnitus. PMID: 27340988
7. study shows that the a-adducin G460T polymorphism is associated with essential hypertension PMID: 27349000
8. Study shows that ADD1-rs4963 conferred susceptibility to colorectal cancer (CRC) suggesting an association between ADD1 and CRC risk. PMID: 25816007
9. The T allele of ADD1 is associated with essential hypertension in Asians. PMID: 26042478
10. study of potential effects of interaction between DNA methylation of ADD1 promoter and ADD1 tagSNPs and environmental factors on essential hypertension (EH); results indicate ADD1 SNP rs4961 has a protective role in development of EH; interactions between alcohol consumption and DNA methylation of ADD1 gene promoter have a significant role in modifying EH susceptibility PMID: 25567773
11. There were significant differences between the control group and pediatric hypertensive group in terms of ACE I/D (P<0.05) and AGT M235T (P<0.05) polymorphisms, but there were no differences in ADD Gly460Trp (P>0.05) polymorphism. PMID: 25262176
12. A significant association was found between ADD1 gene G614T polymorphism and essential hypertension in Chinese patients. Further studies need to be done to confirm these findings in a large sample. PMID: 24718403
13. When alpha-adducin complexes with sodium potassium ATPase in astrocytes, non-cell autonomous neurodegeneration is triggered. PMID: 25344630
14. Data indicate that adducin promotes adhesion by regulating desmosomes and is part of a protective pathway in pemphigus. PMID: 24711455
15. Phosphorylation of ADD1 at Ser12 and Ser355 by cyclin-dependent kinase 1 enables ADD1 to bind to myosin-X (Myo10). PMID: 24379415
16. Fnnctional polymorphism in the phosphorylation site of ADD1 (rs4963) may influence the susceptibility of non-cardia gastric cancer. PMID: 23985264
17. concentration of AST was inversely correlated with ADD1 CpG2-5 methylation levels in female controls. These observations may bring new hints to elaborate the pathogenesis of essential hypertension PMID: 23691048
18. study is the first meta-analysis to evaluate the influences of ACE and ADD1 polymorphisms on blood pressure responses to hydrochlorothiazide to combine the inconsistent results of previous studies PMID: 23863317
19. the rs4963 polymorphism within ADD1 gene is associated with essential hypertension in the Chinese population PMID: 23509723
20. role of ADD1 gene polymorphism in hypertension PMID: 22810272
21. there was no association of ACE and ADD1 gene polymorphism in ischaemic stroke patients PMID: 23540412
22. genotype and allele frequencies of ACE and ADD1 polymorphisms were compared between patients and controls as well as between ischemic stroke and ICH PMID: 21194526
23. Hypertension-linked mutation of alpha-adducin increases CFTR surface expression and activity in HEK and cultured rat distal convoluted tubule cells. PMID: 23284854
24. Variant genotype combinations of ACE and alphaADDUCIN render the hypertensive patient more vulnerable to recurrent intracerebral hemorrhage PMID: 22198647
25. genetic variants of the ADD1 and GNB3 genes may have important roles in blood pressure response to the cold pressor test PMID: 22476228
26. organization of a spectrin-like cytoskeleton is associated with keratinocyte differentiation, and cytoskeleton disruption is mediated by either PKCdelta(Thr505) phosphorylation associated with phosphorylated adducin or due to reduction of endogenous adducin PMID: 22163289
27. The alpha-adducin Gly460Trp gene polymorphism might modulate renal function decline in the Chinese. PMID: 22677360
28. Findings support a role for alpha-adducin in memory from nematodes to humans. PMID: 22307086
29. Data show that alpha-adducin G460W gene polymorphism was linked to essential hypertension (EH) susceptibility. PMID: 22272309
30. Further studies involving siRNA-mediated knockdowns of spectrin, adducin, or p4.1 revealed that those proteins are needed for efficient docking of enterohaemorrhagic Escherichia coli to host cells. PMID: 22197999
31. the mechanism for alpha-adducin to shuttle between the cytoplasm and nucleus; a potential role for alpha-adducin in mitosis. PMID: 21736685
32. In the studied Russian population G460W polymorphism of ADD1 gene can be considered as predisposition gene to hypertension, but its pathological effect is manifested solely under influence of environmental factors. PMID: 22117679
33. Null association of alpha-adducin G460T and GNB3 C825T polymorphisms with hypertension in Chinese, but local marginal significance of C825T, as a putative salt-sensitive switch, in southern Chinese. PMID: 21364877
34. this meta-analysis suggests that the Gly460Trp polymorphism might increase the risk of hypertension in Chinese populations, especially in Han Chinese. PMID: 21228790
35. ADD1 variant genotypes were not associated with increased risk but in association with ACE DD genotype resulted in significantly higher risk of PSICH. ACE and ADD1 variant genotypes were associated with nonlobar hematoma. PMID: 21339657
36. These findings suggest novel roles for adducins in stabilization of epithelial junctions and regulation of junctional remodeling. PMID: 20810786
37. Alpha-adducin Gly460Trp polymorphism is associated with hypertension. PMID: 20927398
38. Genetic variration in alpha adducion alter renal function and/or vasoreactivity are logical candidates to explain some of the individual variability in the blood pressure response to exercise. PMID: 20929695
39. Although the effect of both genetic variants on CIMT was small, this study showed a statistically significant effect of AGTR1 and ADD1 in women PMID: 19620885
40. The alpha-adducin gene G460W polymorphism was not associated with hypertension in either a case-control study of essential hypertension in Shangha residents or in a meta-analysis of all reports in English. PMID: 19960031
41. ALPHA AND BETA ADDUCIN POLYMORPHISMS AFFECT DECLINE OF RENAL FUNCTION IN HUMAN IGA NEPHROPATHY. PMID: 19838659
42. Alpha-adducin Gly460Trp polymorphism is associated with salt-sensitivity. PMID: 20145305
43. The alpha-adducin G614T polymorphism is associated with the antihypertensive effect of hydrochlorothiazide. PMID: 16266470
44. effects of environmental, demographic, & genetic factors & their interactions to SBP response to antihypertensive drugs, explained 23% of the total variance. Ethnicity, low sodium intake, & ADD1 614G-->T polymorphism were the only drug-related predictors PMID: 19779464
45. Role of the alpha-adducin genotype on renal disease progression. PMID: 11918733
46. interaction between diuretic therapy and the adducin variant on the incidence of myocardial infarction and stroke PMID: 11926892
47. ADD1 460W allele associated with cardiovascular disease in hypertensive individuals PMID: 12052841
48. Blood pressure in patients with primary aldosteronism is influenced by alpha-adducin gene polymorphisms. PMID: 12107246
49. Carotid and femoral intima-media thickness were assessed in subjects genotyped for the presence of the ACE D, aldosterone synthase -344T and alpha-adducin 460Trp alleles. PMID: 12172317
50. Patients homozygous for the allele of that polymorphism had a LV mass index significantly higher compared with heterozygotes or homozygotes. These subjects also have significantly lower plasma renin activity. PMID: 12195118

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HGNC: 243

OMIM: 102680

KEGG: hsa:118

STRING: 9606.ENSP00000264758

UniGene: Hs.183706