Recombinant Human Annexin A8 (ANXA8)

Code CSB-YP001849HU
MSDS
Size Pls inquire
Source Yeast
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Code CSB-EP001849HU
MSDS
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Source E.coli
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Code CSB-EP001849HU-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP001849HU
MSDS
Size Pls inquire
Source Baculovirus
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Code CSB-MP001849HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
ANXA8
Uniprot No.
Alternative Names
Annexin A8; Annexin VIII; Annexin-8; ANX8; Anxa8; ANXA8_HUMAN; VAC beta; VAC-beta; Vascular anticoagulant beta; Vascular anticoagulant-beta
Species
Homo sapiens (Human)
Expression Region
1-327
Target Protein Sequence
MAWWKSWIEQ EGVTVKSSSH FNPDPDAETL YKAMKGIGTN EQAIIDVLTK RSNTQRQQIA KSFKAQFGKD LTETLKSELS GKFERLIVAL MYPPYRYEAK ELHDAMKGLG TKEGVIIEIL ASRTKNQLRE IMKAYEEDYG SSLEEDIQAD TSGYLERILV CLLQGSRDDV SSFVDPGLAL QDAQDLYAAG EKIRGTDEMK FITILCTRSA THLLRVFEEY EKIANKSIED SIKSETHGSL EEAMLTVVKC TQNLHSYFAE RLYYAMKGAG TRDGTLIRNI VSRSEIDLNL IKCHFKKMYG KTLSSMIMED TSGDYKNALL SLVGSDP
Protein Length
Full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.
Gene References into Functions
  1. These findings identify Anxa8 as a regulator of late endosomes/lysosomes cholesterol balance. PMID: 29306076
  2. We conclude that AnxA8 affects CD63/VEGFR2/beta1 integrin complex formation, leading to hyperactivation of the VEGF-A signal transduction pathway, and severely disturbed VEGF-A-driven angiogenic sprouting. PMID: 28060564
  3. Annexins A2 and A8 in endothelial cell exocytosis and the control of vascular homeostasis PMID: 27451994
  4. Increased annexin A8 expression is associated with poor prognosis in early-stage pancreatic cancer. PMID: 25268673
  5. High ANXA8 gene expression is associated with lymph node metastasis in oral squamous cell carcinoma. PMID: 26700817
  6. Annexin A8 controls leukocyte recruitment to activated endothelial cells via cell surface delivery of CD63. PMID: 24769558
  7. High ANXA8 expression is associated with pancreatic cancer. PMID: 23001853
  8. Define a distinct bone-dependent genetic program associated with terminal osteoclast differentiation and identified Anxa8 as a gene strongly induced late in osteoclast differentiation, regulating formation of the cell's characteristic actin ring. PMID: 21344395
  9. Annexin A8 is involved in mouse mammary gland involution and progression of human breast cancer PMID: 16203777
  10. binds Ca2+-dependently and with high specificity to phosphatidylinositol (4,5)-bisphosphate (PtdIns(4,5)P2) and is also capable of interacting with F-actin PMID: 16638567
  11. Data suggest that defective transport through the late endocytic pathway and imbalanced signaling in the absence of annexin A8 results from disturbed association of late endosomal membranes with actin and impaired endosome motility. PMID: 18923148

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Protein Families
Annexin family
Database Links

HGNC: 546

OMIM: 602396

KEGG: hsa:653145

STRING: 9606.ENSP00000341674

UniGene: Hs.535306

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