Recombinant Human Aurora kinase C (AURKC)

1. Teratozoospermia is not correlated with c.144delC mutation in the AURKC gene in the men of the Sichuan area. Therefore, large-scale genotyping of the AURKC gene may not be necessary clinically among Chinese patients with idiopathic teratozoospermia. PMID: 29738175
2. The epigenetic targets AURKB, AURKC and DNMT3B, and the global DNA methylation profile are regulated during HIV-1 replication in CD4+ T cells, and this regulation can be influenced by the activation state of the cell at the time of infection. PMID: 30077875
3. Two novel DMRs, located in RPS6KA4/MIR1237 and the AURKC promoter, were found to be hypermethylated in WT PMID: 28930610
4. Identification and characterization of AURKB and AURKC variants associated with maternal aneuploidy has been reported. PMID: 28369513
5. Aurora-C interactions with members of the Chromosome Passenger Complex (CPC), Survivin and Inner Centromere Protein (INCENP) in reference to known Aurora-B interactions to understand the functional significance of Aurora-C overexpression in human cancer cells, is reported. PMID: 27332895
6. Patients presenting with a monomorphic teratozoospermia such as globozoospermia or macrospermia with more than 85% of the spermatozoa presenting this specific abnormality have been analyzed permitting to identify several key genes for spermatogenesis such as AURKC and DPY19L2. PMID: 27779748
7. Homozygous c.144delC mutation in AURKC gene in infertile men with macrozoospermia in the Tunisian population PMID: 26341096
8. AURKC mutations are more frequent than Klinefelter syndrome and constitute the leading genetic cause of infertility in North African men. PMID: 25219909
9. Low AURKC expression is associated with cancer. PMID: 25990457
10. Overexpression of AURKC is associated with breast tumors. PMID: 25994570
11. may play an important role in the development of colorectal cancer PMID: 26118178
12. Aberrantly expressed Aurora-C in somatic cancer cells may impair spindle checkpoint assembly by displacing the centromeric localization of chromosomal passenger complexes. PMID: 24603334
13. Our data indicate that the AURKC c.144delC mutation has a relatively high carrier frequency in the Moroccan population. PMID: 24484996
14. expression of AURKC, OIP5, PIWIL2 and TAF7L differed between patients with Acute myeloid leukemia, myelodysplastic syndrome and healthy controls in a gender-dependent manner PMID: 23292864
15. Here we provide evidence for the first time of Aurora-C overexpression and gene amplification. PMID: 23581231
16. Investigators identified a new non-sense mutation in aurora kinase C, p.Y248*, in 10 unrelated individuals of European and North African origin; this mutation is associated with macrozoospermia and male infertility. PMID: 22888167
17. Molecular analysis of the AURKC gene was carried out in two brothers presenting with a typical large-headed spermatozoa phenotype. Both affected brothers were heterozygous for the c.144delC mutation in the AURKC gene. PMID: 21733974
18. Aurora C mRNA is up-regulated with Aurora B after activation of the embryonic genome and both proteins were detected in early Day 4 embryos. PMID: 21493633
19. we show that elevated AURKC increases the proliferation, transformation and migration of cancer cells PMID: 21710690
20. Overexpressed Aurora-C (AURKC) is an oncogene. Overexpression of Aurora-C induces abnormal cell division resulting in centrosome amplification and multinucleation. Cells overexpressing active Aurora-C induced tumour formation in nude mice. PMID: 22046298
21. We confirm in this study the research interest of the recurrent mutation c.144delC in the gene AURKC in male infertility with high rates of large-headed spermatozoa PMID: 21353399
22. the study demonstrated that TACC1 localizes at the midbody during cytokinesis and interacts with and is a substrate of Aurora-C, which warrant further investigation in order to elucidate the functional significance of this interaction. PMID: 21531210
23. Aurora-C mRNA was reduced to 0.20 +/- 0.32 fold (P < 0.01) in 13 seminomas and up-regulated in one case PMID: 20629650
24. association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C PMID: 15316025
25. Aurora-C interacts with the inner centromere protein (INCENP) at the carboxyl terminal end spanning the conserved IN box domain. PMID: 15499654
26. Therefore, we speculated that Aurora C-SV might also contribute to the regulation of chromosome segregation and cytokinesis. PMID: 15670791
27. Aurora-C is a chromosomal passenger protein that disrupts the association of INCENP with Aurora-B and may serve as a key regulator in cell division PMID: 15917996
28. Aurora-c is directly associated with surwvivin and is required for cytokinesis. PMID: 15938719
29. A role of Aurora-C in the development and progression of cancer especially in the presence of mutated p53. PMID: 16258285
30. Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility. PMID: 17435757
31. Results demonstrate that human Auroras a regulator of cell morphology and cell growth, and that the non-conserved T191 in the activation loop of Auroras of major importance for its regulation. PMID: 17637569
32. Aurora C phosphorylates TRF2 PMID: 18309533
33. A functional AURKC protein is necessary for male meiotic cytokinesis while its absence does not impair oogenesis. PMID: 19147683
34. Aurora-C can perform the same essential functions as Aurora-B in mitosis: regulation of kinetochore-microtubule attachments, the spindle assembly checkpoint, and cytokinesis PMID: 19713763

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HGNC: 11391

OMIM: 243060

KEGG: hsa:6795

STRING: 9606.ENSP00000302898

UniGene: Hs.98338