Your Good Partner in Biology Research
Tel : 301-363-4651
Your Good Partner in Biology Research
| Code | CSB-EP002613HU |
| Product Type | Recombinant Protein |
| Size | US$1726 |
| Uniprot No. | Q07817 |
| Relevance | Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial mbrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial mbrane ATP synthase F1F0 activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles.Isoform Bcl-X(S) promotes apoptosis. |
| Image |
|
| Storage Buffer | Tris-based buffer,50% glycerol |
| Alias | Apoptosis regulator Bcl-X |
| Species | Homo sapiens (Human) |
| Purity | Greater than 90% as determined by SDS-PAGE. |
| Sequence | MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQER |
| Research Area | Cancer |
| Source | E.coli |
| Gene Names | BCL2L1 |
| Expression Region | 1-209aa |
| Tag Info | N-terminal 6xHis-SUMO-tagged |
| Mol. Weight | 39.4kDa |
| Protein Description | Partial |
| Storage | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. |
| Notes | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Function | Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.; FUNCTION |
| Subcellular Location | Isoform Bcl-X(L): Mitochondrion inner membrane, Mitochondrion outer membrane, Mitochondrion matrix, Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane, Cytoplasm, cytosol, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Nucleus membrane, Single-pass membrane protein, Cytoplasmic side |
| Protein Families | Bcl-2 family |
| Tissue Specificity | Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain. |
| Database Links |
HGNC: 992 OMIM: 600039 KEGG: hsa:598 STRING: 9606.ENSP00000302564 UniGene: Hs.516966 |
| Pathway |
Jak-STAT signaling pathway
PI3K-Akt signaling pathway NF-kappa B signaling pathway Apoptosis Autophagy Ras signaling pathway NOD-like receptor signaling pathway |
BCL2L1 Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-MA0026131A0m | BCL2L1 Monoclonal Antibody | Human | ELISA,WB,IHC |
| CSB-PA002613KA01HU | BCL2L1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA027199GA01HU | BCL2L1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA002613HB01HU | BCL2L1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA002613HC01HU | BCL2L1 Antibody, FITC conjugated | Human | ELISA |
| CSB-PA002613HD01HU | BCL2L1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA923588 | BCL2L1 (Ab-62) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA000986 | BCL2L1 Antibody | Human,Mouse,Rat | WB,IHC,IF,ELISA |
| CSB-PA000987 | BCL2L1 Antibody | Human,Mouse,Rat | WB,IHC,ELISA |
| CSB-PA040205 | Phospho-BCL2L1 (S62) Antibody | Human,Mouse,Rat | WB,IHC,ELISA |
| CSB-PA040206 | Phospho-BCL2L1 (T47) Antibody | Human,Mouse,Rat | WB,IHC,IF,ELISA |
| CSB-PA040207 | Phospho-BCL2L1 (T115) Antibody | Human,Mouse,Rat | IHC,ELISA |
| CSB-PA040208 | BCL2L1 Antibody | Human,Mouse,Rat | IHC,ELISA |
| CSB-PA080279 | BCL2L1 Antibody | Human,Mouse,Rat | IHC |
| CSB-PA223208 | BCL2L1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA315068 | BCL2L1 Antibody | Human,Mouse,Rat | ELISA,WB |
BCL2L1 Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA002613HA01HU | BCL2L1 Antibody | Human, Mouse | ELISA, WB, IHC, IF |
BCL2L1 Antibodies for
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA786016 | Phospho-BCL2L1 (Ser62) Antibody | Human, Mouse, Rat | ELISA, WB, IHC, IF |
BCL2L1 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP002613HU CSB-BP002613HU CSB-MP002613HU |
Recombinant human Bcl-2-like protein 1 | Yeast Baculovirus Mammalian cell |
BCL2L1 ELISA Kit for Homo sapiens (Human)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-EL002613HU | Human Bcl-2-like protein 1(BCL2L1) ELISA kit | serum, plasma, tissue homogenates | 0.156 ng/mL |
Recombinant Human Transcriptional enhancer factor TEF-1(TEAD1)
Express system: Yeast
Species: Homo sapiens (Human)
Recombinant Mouse Interferon regulatory factor 8(Irf8)
Express system: E.coli
Species: Mus musculus (Mouse)
Recombinant Human Diacylglycerol kinase gamma(DGKG),partial
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human Translation initiation factor eIF-2B subunit beta(EIF2B2)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human Eukaryotic translation initiation factor 3 subunit E(EIF3E)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human Coagulation factor VII(F7),partial
Express system: Yeast
Species: Homo sapiens (Human)
Recombinant Human Phenylalanine-4-hydroxylase(PAH)
Express system: E.coli
Species: Homo sapiens (Human)
