BCL2L1

BCL2L1, B-cell lymphoma/leukemia 2-like protein 1, alias BCL2L01, Bcl-2-related protein A1, Bfl-1, etc. BCL2L1 is an anti-apoptotic protein, a member of the Bcl-2 family, encoded by its own gene in human cells. It plays an important role in the regulation of apoptosis and inhibits the mitochondria-mediated apoptotic pathway mainly by interacting with pro-apoptotic proteins such as Bax or Bak.The mechanism of action of BCL2L1 involves its dynamic distribution between the cytoplasm and mitochondria, as well as its modulation of the permeability of the mitochondrial membrane.

The biological significance of BCL2L1 is very broad, and it participates in cellular response to a variety of stresses It is involved in cellular adaptation to a variety of stress responses, including oxidative stress, DNA damage, cytokine-induced stress, etc. BCL2L1 expression is regulated by a variety of signaling pathways, such as p53, NF-κB, MAPK, etc., which play a key role in the balance between cell survival and apoptosis.Abnormal BCL2L1 function is associated with the development of a variety of diseases, especially closely related to the development of tumors. In tumor cells, overexpression of BCL2L1 contributes to the escape of tumor cells from immune surveillance and chemotherapy-induced apoptosis, making it a potential target in tumor therapy.