BCL2L1 (Ab-62) Antibody

Datasheet
Code CSB-PA923588
Product Type Polyclonal Antibody
Size US$297
Uniprot No. Q07817
Image
  • Western blot analysis of extracts from 293 and Hela cells using BCL-XL(Ab-62) antibody.
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunogen Peptide sequence around aa.60~64 (A-D-S-P-A) derived from Human BCL-XL .
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Specificity The antibody detects endogenous level of total BCL-XL protein.
Tested Applications ELISA,WB;WB:1:500-1:1000
Relevance Potent inhibitor of cell death. Isoform Bcl-X(L) anti-apoptotic activity is inhibited by association with SIVA isoform 1. Inhibits activation of caspases By similarity. Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, cytochrome c, from the mitochondrial membrane. The Bcl-X(S) isoform promotes apoptosis.

Basu A, et.al.( 2003) Mar 13; 538(1-3): 41-7
Cheng E.H.-Y. et.al. (1996) Nature 379:554-556.
Sattler M. et.al. (1997), Science 275:983-986.
Muchmore S.W.et.al (1996).Nature 381:335-341
Yu J., Zhang L. Mol. (2001)Cell 7:673-682
Form Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality Polyclonal
Alias Apoptosis regulator Bcl-X
Immunogen Species Homo sapiens (Human)
Target Names BCL2L1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.; FUNCTION
Subcellular Location Isoform Bcl-X(L): Mitochondrion inner membrane, Mitochondrion outer membrane, Mitochondrion matrix, Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane, Cytoplasm, cytosol, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Nucleus membrane, Single-pass membrane protein, Cytoplasmic side
Protein Families Bcl-2 family
Tissue Specificity Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain.
Database Links

HGNC: 992

OMIM: 600039

KEGG: hsa:598

STRING: 9606.ENSP00000302564

UniGene: Hs.516966

Pathway Jak-STAT signaling pathway
PI3K-Akt signaling pathway
NF-kappa B signaling pathway
Apoptosis
Autophagy
Ras signaling pathway
NOD-like receptor signaling pathway

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