Code | CSB-RA247982A0HU |
Size | US$210 |
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Application | Recommended Dilution |
---|---|
WB | 1:500-1:5000 |
IHC | 1:50-1:200 |
The process of creating the BCL2L1 recombinant monoclonal antibody is complex and requires a series of steps. Firstly, the BCL2L1 monoclonal antibody is extracted, and its gene sequence is analyzed. Then, a vector carrying the BCL2L1 monoclonal antibody gene is built and transfected into a host cell line for culturing. The antibody is synthesized using a synthetic peptide derived from human BCL2L1 as an immunogen. Afterward, the BCL2L1 recombinant monoclonal antibody is purified via affinity chromatography to ensure its high purity. Finally, the specificity of this antibody is confirmed by ELISA, WB, and IHC assays, which examine its ability to recognize BCL2L1 effectively. It can react with human, mouse, and rat BCL2L1 proteins.BCL2L1 is an anti-apoptotic protein that plays a critical role in regulating apoptosis and mitochondrial function.
BCL2L1 protein prevents apoptosis by inhibiting the activity of pro-apoptotic proteins such as BAX and BAK. It promotes mitochondrial fusion and inhibits fission, processes that are important for maintaining mitochondrial morphology and function. BCL2L1 also regulates mitochondrial metabolism by modulating the activity of the electron transport chain and the generation of reactive oxygen species (ROS). BCL2L1 promotes cell survival by regulating the activity of various signaling pathways, such as the NF-κB, PI3K-AKT, and MAPK pathways. It also protects cells from oxidative stress, DNA damage, and other forms of cellular stress by regulating the expression of antioxidant genes and DNA repair enzymes. Dysregulation of BCL2L1 can contribute to the development and progression of cancer.
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