Product Details

Purity

>85% (SDS-PAGE)

Target Names

CLEC4A

Uniprot No.

Q9UMR7

Alternative Names

C type (calcium dependent carbohydrate recognition domain) lectin superfamily member 6; C type lectin; C type lectin DDB27; C type lectin superfamily 6; C-type (calcium dependent; carbohydrate-recognition domain) lectin; superfamily member 6; C-type lectin superfamily member 6; C-type lectin DDB27; C-type lectin domain family 4 member A; C-type lectin domain family 4; member A; C-type lectin domain family 4; member a2; C-type lectin superfamily member 6; CLC4A_HUMAN; Clec4a; Clec4a2; CLECSF6; DCIR; Dcir1; DDB27; Dendritic cell immunoreceptor; HDCGC13P; Lectin like immunoreceptor; Lectin; C-type; superfamily member 6; Lectin-like immunoreceptor; LLIR

Species

Homo sapiens (Human)

Protein Length

Partial

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose, pH 8.0

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

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Target Background

Function

C-type lectin receptor that binds carbohydrates mannose and fucose but also weakly interacts with N-acetylglucosamine (GlcNAc) in a Ca(2+)-dependent manner. Involved in regulating immune reactivity. Once triggered by antigen, it is internalized by clathrin-dependent endocytosis and delivers its antigenic cargo into the antigen presentation pathway resulting in cross-priming of CD8(+) T cells. This cross-presentation and cross-priming are enhanced by TLR7 and TLR8 agonists with increased expansion of the CD8(+) T cells, high production of IFNG and TNF with reduced levels of IL4, IL5 and IL13. In plasmacytoid dendritic cells, inhibits TLR9-mediated IFNA and TNF production. May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation.; (Microbial infection) Involved in the interaction between HIV-1 virus and dendritic cells. Enhances HIV-1 binding/entry and virus infection. Requires ITIM motif-associated signal transduction pathway involving phosphatases PTPN6 and PTPN11, SYK, Src kinases and MAP kinases.

Gene References into Functions

Authors have determined the structure, tissue distribution, and molecular function of the cartilage-specific lectin CLEC3A and show that CLEC3A binds to plasminogen and participates in tPA-mediated plasminogen activation. PMID: 29146595
DCIR SNP rs2377422 is a novel genetic susceptibility factor for both SLE and primary SS. PMID: 26429306
this study shows that sulfo-Lewis(a) is a high affinity ligand for DCIR and that DCIR interacts with ligands from both pathogenic and endogenous origin of which most are shared by DC-SIGN. PMID: 24239607
No association was found between our inflammatory bowel disease cohort and the candidate single nucleotide polymorphisms for DCIR (CD/HC: P=0.22 and UC/HC: P=0.41) PMID: 22664939
Data provide evidence for association between DCIR rs2377422 and RA in non-Caucasian populations and confirm the influence of DCIR polymorphisms on RA susceptibility, especially on ACPA-negative RA. PMID: 22829930
An involvement of ITIM domain in HIV-1-mediated signaling events and a relationship between phosphorylation events and DCIR function with respect to HIV-1 biology. PMID: 21536857
Data show that antigen targeting via the DCIR receptor allows activation of specific CD8(+) T-cell immunity. PMID: 20530286
CLECSF6 is involved in the control of inflammation in neutrophils PMID: 14550269
The phosphorylation of SHP-2 by GM-CSF promotes the binding of SHP-2 to the GM-CSF receptor to the disadvantage of CLECSF6. PMID: 16360206
Human APLEC and DCIR may be associated with susceptibility to anti-CCP-negative rheumatoid arthritis. PMID: 17665455
The data show that targeting of DCIR can modulate human plasmacytoid dendritic cell function and may be applied in disease prevention and treatment. PMID: 18258799
The mRNA expression from the four known transcripts of DCIR in IFN-gamma-treated human leukocytes together with fine mapping across the locus was analyzed. PMID: 18480830
can participate in the capture of HIV-1 and promote infection in trans and in cis of autologous CD4(+) T cells from human immature monocyte-derived DCs. PMID: 18541725
DCIR as an antigen presenting cell receptor that is endocytosed efficiently in a clathrin-dependent manner and negatively affects TLR8-mediated cytokine production. PMID: 19028959

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Subcellular Location

Cell membrane; Single-pass type II membrane protein; Extracellular side.

Tissue Specificity

Expressed preferentially in hematopoietic tissues. Expressed in all circulating Ag-presenting cells such as dendritic cells, myeloid cells, monocytes, macrophages, B-cells and epidermal Langerhans cells (at protein level). Expressed in peripheral blood le

Database Links

HGNC: 13257

OMIM: 605306

KEGG: hsa:50856

STRING: 9606.ENSP00000229332

UniGene: Hs.504657

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Recombinant Human C-type lectin domain family 4 member A (CLEC4A), partial

Product Details

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Target Background

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