Recombinant Human Calretinin(CALB2)

Code CSB-YP004433HU
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Source Yeast
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Code CSB-EP004433HU
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Source E.coli
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Code CSB-EP004433HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP004433HU
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Source Baculovirus
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Code CSB-MP004433HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names CALB2
Uniprot No. P22676
Alternative Names 29 kDa calbindin; CAB 29; CAB29; CAL 2; CAL2; CALB 2; CALB2; CALB2_HUMAN; Calbindin 2 29kDa; Calbindin 2; Calbindin D29K; Calbindin2; Calretinin; CR
Species Homo sapiens (Human)
Expression Region 1-271
Target Protein Sequence MAGPQQQPPY LHLAELTASQ FLEIWKHFDA DGNGYIEGKE LENFFQELEK ARKGSGMMSK SDNFGEKMKE FMQKYDKNSD GKIEMAELAQ ILPTEENFLL CFRQHVGSSA EFMEAWRKYD TDRSGYIEAN ELKGFLSDLL KKANRPYDEP KLQEYTQTIL RMFDLNGDGK LGLSEMSRLL PVQENFLLKF QGMKLTSEEF NAIFTFYDKD RSGYIDEHEL DALLKDLYEK NKKEMNIQQL TNYRKSVMSL AEAGKLYRKD LEIVLCSEPP M
Protein Length Full length protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function Calretinin is a calcium-binding protein which is abundant in auditory neurons.
Gene References into Functions
  1. we have identified septin 7, an essential cellular component implicated in the final steps of cell division, as a strong Bt-dependent gene regulatory protein binding to the promoter of CALB2. PMID: 29699512
  2. Calretinin was positive in 20 cases with MM. PMID: 27761727
  3. Calretinin could be verified as a blood-based marker for Malignant mesothelioma (MM). The assay is robust and shows a performance that is comparable to that of mesothelin. Retrospective analyses would not be limited by storage time. The high specificity supports a combination of calretinin with other markers. PMID: 28558669
  4. calretinin increases Leydig cell viability and proliferation, possibly via ERK1/2 and AKT pathways, and suppresses apoptosis possibly via the mitochondria-related apoptotic pathway PMID: 28437248
  5. expression of calretinin in human fetal testis specimens, was examined. PMID: 27990638
  6. In Malignant mesothelioma , increased calretinin expression is associated with epithelioid histology and better survival. PMID: 27780599
  7. Calretinin, D2-40 and mesothelin are aberrantly expressed in a proportion of CRC cases. PMID: 27062033
  8. We studied 38 bone marrow biopsy specimens of non-CML myeloproliferative neoplasms from 31 patients. All eight bone marrow biopsy specimens from patients with mutant CALR showed strong cytoplasmic staining of the megakaryocytes (83.5%; range, 50%-98%; median, 87%) with the CAL2 antibody. PMID: 27686170
  9. NCX1 and the calcium binding protein calretinin cooperate within the striatum to confer tolerance against cerebral ischemia. PMID: 25633096
  10. Overexpression of human calretinin in mouse primary mesothelial cells inversely affects proliferation and cell migration. PMID: 26695618
  11. Patients with Down syndrome may have enteric nervous system disorders functionally similar to HD, related to abnormal or imbalanced autonomic innervation, of which distal calretinin hypoinnervation is one manifestation, despite the presence of ganglia. PMID: 26230373
  12. the unique disposition of CALR at the MII spindle uncovers a physical interaction with endoplasmic reticulum that may mediate cytoskeletal remodelling during oocyte maturation. PMID: 25620022
  13. In focal cortical dysplasia (FCD), the density of CR positive neurons was increased in cortical layer V compared to non-FCD temporal lobe. PMID: 26081613
  14. might be used as a marker for the ameloblastomas and could play an important role in the differentiation of aggressiveness of different odontogenic tumors PMID: 25046230
  15. We concluded that WT1, but not calretinin, is a useful prognostic factor in malignant pleural mesothelioma PMID: 24323466
  16. This article reviews the information that is currently available on calretinin expression in tumors and on its application as an immunohistochemical marker in diagnostic pathology. PMID: 24185118
  17. Calretinin positivity was observed in all rectal biopsies of Hirschsprung disease showing the presence of ganglion cells, and the staining was consistently absent in all cases of aganglionosis. PMID: 25119007
  18. Calretinin IHC offered additional diagnostic value in the Hirschprung disease using specimens with inadequate amount of submucosa and rarely seen ganglion cells. PMID: 24294384
  19. calretinin immunoexpression and the hormonal status for estrogen receptors (ER), progesterone receptors (PR), and ERRB2, in 33 cases of cutaneous metastases of ductal breast carcinoma, as well as in seven primary cutaneous apocrine tumors, were studied PMID: 24322014
  20. Restricted diffusion of calretinin in cerebellar granule cell dendrites implies Ca(2)-dependent interactions via its EF-hand 5 domain. PMID: 23732647
  21. Calretinin was found in nerve fibrils in all of the fetal colonic samples. Calretinin was expressed in the gut as early as 22 gestational weeks. PMID: 23701779
  22. CD34/calretinin immunohistochemistry could be useful for differentiating sinonasal schwannoma from its histological mimics. PMID: 23995573
  23. high-level calretinin expression in invasive ductal carcinoma of the breast is most common in grade 3 tumors with a basal-like phenotype and is associated with poor overall survival. PMID: 24262018
  24. Data indicate that fallopian tube and the epithelial component of Brenner tumours (BTs) expressed AKR1C3 and androgen receptor, but the tumour stromal cells showed strong expression of calretinin, inhibin and steroidogenic factor 1 in the majority of BTs. PMID: 24012099
  25. All 12 patients without Hirschsprung disease had calretinin-positive nerve fibers in the lamina propria or muscularis mucosae, and all 5 patients with Hirschsprung disease had no calretinin staining of nerves. PMID: 23899067
  26. High Calretinin expression is associated with mesothelioma. PMID: 23595591
  27. Our results show that different levels of serous ovarian tumor progression are accompanied by changes in the immunohistochemical expression pattern of EpCAM, CD24, and calretinin PMID: 23011824
  28. an unexpected role for CR in directly modulating effectors such as Ca(v)2.1, which may have major consequences for Ca(2+) signaling and neuronal excitability. PMID: 23033479
  29. This study demonistrated that significant linear regression between calbindin expression and short-term and long-term percent retention of auditory verbal learning test in patients whose epilepsy PMID: 22796338
  30. Data show that calretinin and CK5/6 were positive in 100 and 64% of mesotheliomas, and 92 and 31% of reactive effusions, respectively, and desmin was negative in all malignant cases and positive in 85% of reactive effusions. PMID: 23075894
  31. Over-expression of CR reduces huntingtin-caused cytotoxicity in both non-neuronal and neuronal cell models of Huntington's disease. PMID: 22891683
  32. A set of cryosections revealed extensive colocalization of calretinin with vasoactive intestinal peptide in both surviving submucosal perikarya and mucosal nerve fibres in human chagasic submucosa and mucosa. PMID: 22555304
  33. Immunohistochemical study of calretinin expression in normal skin and cutaneous adnexal proliferations. PMID: 22343111
  34. Low calretinin is associated with high neutrophil-to-lymphocyte ratio and malignant mesothelioma. PMID: 22011651
  35. Calretinin appears to be a useful marker to distinguish Olfactory neuroblastoma from other small round blue cell tumors PMID: 22020045
  36. Results suggest that following 5-FU treatment in CRC cell lines, CALB2 is involved in apoptosis induction through the intrinsic mitochondrial pathway. This indicates that CALB2 may be an important mediator of 5-FU-induced cell death PMID: 21629658
  37. calretinin-containing cells in the human hippocampus are highly vulnerable, thus inhibition mediated by dendritic inhibitory cells and their synchronization by interneuron-specific interneurons may be impaired in epilepsy. PMID: 20576695
  38. Developed a novel and sensitive ELISA for the detection of calretinin in serum, heparin plasma, or EDTA plasma augmented with calcium from mesothelioma patients. PMID: 20509881
  39. identification of two elements that act as butyrate-sensitive repressors in all colon cancer cell lines tested PMID: 19998412
  40. The overall density of Calretinin neurons in cerebral cortex was significantly decreased in focal cortical dysplasias. PMID: 19854615
  41. Calretinin plays a crucial role in the modulation of intrinsic neuronal excitability and the induction of long-term potentiation. PMID: 19450707
  42. a tumor marker for cardiac myxoma PMID: 11642722
  43. Two types of calretinin-immunostained terminals were found in the CA1 region. PMID: 12064772
  44. AP2-like cis element acts as an enhancer of gene expression in neuronal cells PMID: 12359331
  45. E-cadherin and calretinin are sensitive and specific in differential diagnosis of benign and malignant serous effusion specimens. PMID: 15285029
  46. Disorders of Sertoli cell differentiation as indicated by calretinin and/or cytokeratin-18 expression contribute to the multifactorial mechanisms underlying spermatogenic failure PMID: 15950053
  47. Calretinin-immunoreactive unipolar brush cells are presented in the vermis after the 28th gestational week. At birth, they are presentm in the vestibular lobules. At the birth the number of calretinin-immunoreactive unipolar brush cells increase. PMID: 16289944
  48. Calretinin immunostaining provides some insights into the histogenesis of invasive and noninvasive implants in serous borderline tumors of the ovary. PMID: 16415795
  49. Cells lining the mesothelial inclusion cysts had CAL2 immunohistochemical reactivity. PMID: 17535091
  50. The combinational characterization of calretinin (either by polyclonal or monoclonal antibody), inhibin alpha, and Melan-A expression is of great significance in the differential diagnosis of adrenocortical tumors. PMID: 18091323

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Protein Families Calbindin family
Tissue Specificity Brain.
Database Links

HGNC: 1435

OMIM: 114051

KEGG: hsa:794

STRING: 9606.ENSP00000307508

UniGene: Hs.106857

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