Recombinant Human Catalase(CAT)

Code CSB-YP004563HU
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Source Yeast
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Code CSB-EP004563HU
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Source E.coli
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Code CSB-EP004563HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP004563HU
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Source Baculovirus
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Code CSB-MP004563HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names CAT
Uniprot No. P04040
Alternative Names Cas1; CAT; CATA_HUMAN; Catalase; Cs1; MGC138422; MGC138424
Species Homo sapiens (Human)
Expression Region 2-527
Target Protein Sequence ADSRDPASD QMQHWKEQRA AQKADVLTTG AGNPVGDKLN VITVGPRGPL LVQDVVFTDE MAHFDRERIP ERVVHAKGAG AFGYFEVTHD ITKYSKAKVF EHIGKKTPIA VRFSTVAGES GSADTVRDPR GFAVKFYTED GNWDLVGNNT PIFFIRDPIL FPSFIHSQKR NPQTHLKDPD MVWDFWSLRP ESLHQVSFLF SDRGIPDGHR HMNGYGSHTF KLVNANGEAV YCKFHYKTDQ GIKNLSVEDA ARLSQEDPDY GIRDLFNAIA TGKYPSWTFY IQVMTFNQAE TFPFNPFDLT KVWPHKDYPL IPVGKLVLNR NPVNYFAEVE QIAFDPSNMP PGIEASPDKM LQGRLFAYPD THRHRLGPNY LHIPVNCPYR ARVANYQRDG PMCMQDNQGG APNYYPNSFG APEQQPSALE HSIQYSGEVR RFNTANDDNV TQVRAFYVNV LNEEQRKRLC ENIAGHLKDA QIFIQKKAVK NFTEVHPDYG SHIQALLDKY NAEKPKNAIH TFVQSGSHLA AREKANL
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
(From Uniprot)
Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.
Gene References into Functions
  1. 'T' allele of C262T showed a protective effect against the risk of ovarian cancer PMID: 29421935
  2. There was no significant association between the CAT gene SNP rs1001179 and Type 1 Diabetes or Diabetic Peripheral Neuropathy. PMID: 29924645
  3. Low CAT expression is associated with childhood obesity. PMID: 29953407
  4. CAT rs769218 GG was associated with poor overall survival compared to GA/AA genotypes in patients without platinum and fluorouracil-based adjuvant chemotherapy. PMID: 30114685
  5. homocysteine reacts with native catalase and/or redox-active transition metal ions to generate thiyl radicals that mediate compound II formation, a temporarily inactive state of the enzyme. PMID: 27848965
  6. Data suggest catalase (CAT) rs769214 (-844 G > A) polymorphism may be associated with N,N-dimethylacetamide (DMAc)-induced abnormal liver function in Chinese population. PMID: 28749186
  7. Maternal catalase activity was found to be lower in neural tube defect-affected pregnancies as compared to healthy controls. PMID: 28397206
  8. Catalase SNPs (C-262T and A-21T) show positive correlation in the model of SNP-SNP interaction in systemic lupus erythematosus. PMID: 28711952
  9. Study identifies an association of the polymorphism of CAT -262C/T in the Algerian population with type 1 diabetes without complications. PMID: 29859283
  10. Findings suggest that gene-environment interactions between the catalase polymorphism rs769214 and mold odor may play an important role in childhood allergic rhinitis development. PMID: 29028686
  11. catalase gene polymorphisms (rs1001179 and rs794316) have roles in cancer susceptibility [meta-analysis] PMID: 27449288
  12. the association between the different Catalase -262C/T genotypes and Catalase levels in seminal plasma and and male infertility PMID: 28436704
  13. This study showed that ADMA, carbonyl groups, CAT and NKA can be useful markers of chronic stress in both males and females with depression, PTSD, and depression concurrent with PTSD. PMID: 28554099
  14. The investigated MnSOD and Catalase polymorphisms do not predispose to the development of alcoholic Chronic Pancreatitis. PMID: 28655148
  15. the CAT C262T polymorphism may be a candidate markerfor cancer risk with type-specific and population-specific effects but not a fine prognostic factor for cancer survival. [meta-analysis] PMID: 27225983
  16. The CAT1 haplotype could be implicated in the level of metabolic and cardiovascular improvement after bariatric surgery. PMID: 29496557
  17. This study showed that CAT functional SNP rs769217 was significantly associated with primary open angle glaucoma (POAG), implying that the CAT gene variants may play a role in the pathogenesis of POAG in the Chinese population. PMID: 28829657
  18. By dividing patients into two groups, increased (P-I/R-I) and decreased TBARS (P-II/R-II) at T12 compared to T0, we found an increased CAT activity in conditioned endothelial cells at T12 in both groups (p=0.05 and p=0.001, respectively). PMID: 28652427
  19. research demonstrated that erysipelas infection predisposition and its clinical characteristics are affected by age, sex and SNPs found in SOD1, SOD2, and catalase genes; presence of SOD1 G7958, SOD2 T2734, and CAT C262 alleles was linked to erysipelas' predisposition PMID: 28512644
  20. A melanoma cell model with low levels of H2O2 induced by catalase overexpression to study differentiation/dedifferentiation processes. PMID: 27206672
  21. Gene expression microarrays in A375 melanoma cells with different ROS levels after overexpressing catalase were performed. Gene expression signature could be relevant in clinical prognostic to classify between non aggressive and metastatic melanomas. PMID: 27206673
  22. It has been shown that the AP-1 family member JunB and retinoic acid receptor alpha (RARa) mediate catalase transcriptional activation and repression, respectively, by controlling chromatin remodeling through a histone deacetylases-dependent mechanism. PMID: 27591797
  23. these findings lend credit to the idea that inefficient catalase import, when coupled with the role of PEX5 as a redox-regulated import receptor, constitutes a cellular defense mechanism to combat oxidative insults of extra-peroxisomal origin. PMID: 28760655
  24. our data suggest that gene polymorphisms of GPX1 Pro198Leu and CAT C262T may have a protective role in the development of primary open-angle glaucoma in a Polish population. PMID: 28547970
  25. Mutated obese carries of SOD1 -251, SOD2 47 and CAT -262 are associated with a higher distribution of fat in comparison with obese wild-type carriers. PMID: 27751366
  26. The present study determined that ARE, CLP, CAT, and MPO levels are different between the pediatric patients with sepsis and healthy controls. ARE level can be a potent biomarker for sepsis in critical patients in intensive care units. PMID: 28167245
  27. Conducted our audit should be extended to more group of patients in order to assess whether or not to confirm the observed during analysis, the protective effect of CAT-262 C / T in ulcerative colitis and other trends observed for other polymorphic variants tested genes. PMID: 28141554
  28. Superoxide dismutase and catalase activities were lower in type 1 myotonic dystrophy patients compared to healthy controls PMID: 26817806
  29. results suggest that, in dyslipidemic patients, the catalase rs1001179 TT genotype is associated with higher HbA1c and plasma triglyceride levels, and that these associations may be modulated by BMI and/or age PMID: 27704307
  30. Study demonstrates that SOD2 rs4880, GPX1 rs1050450 and CAT rs1001179 are not associated with an increased susceptibility to epilepsy after neonatal hypoxic-ischemic encephalopathyor its drug resistance PMID: 28222320
  31. The antioxidative effects of the Mediterranean diet against breast cancer risk may be enhanced by the wild-type alleles of the MnSOD or CAT SNPs among Greek-Cypriot women. PMID: 26130326
  32. The TT genotype distribution for the A/T polymorphism in catalase gene at position -21 was statistically significant differences in eosinophilic Chronic rhinosinusitis with nasal polyps and control groups. PMID: 27515707
  33. Genetic polymorphisms in eNOS, catalase and myeloperoxidase and their significance in a cohort of Turkish prostate cancer patients. PMID: 27706591
  34. Data show that selective and gradual inhibition of membrane-associated catalase of tumor cells or siRNA-mediated knockdown of the total catalase in tumor cells leads to an optimum curve of apoptosis induction. PMID: 28179303
  35. There were significant differences between catalase polymorphisms. The studied polymorphisms showed linkage disequilibrium. The mRNA levels of CAT in the AC/TT, TC/TC, TC/TT, and TC/TC diplotypes significantly were higher than the mRNA levels in AC/AC diplotype. PMID: 27225276
  36. CAT -844G>A (rs769214) polymorphism is associated with the development of Essential Hypertension in smokers. PMID: 27735913
  37. Study showed that endothelial cells from human umbilical vein have a reduced activity and gene expression of the "classic" antioxidant enzymes (Cu,Zn-superoxide dismutase, catalase, and Se-containing glutathione peroxidase). At the same time, a high expression level of peroxiredoxin genes was identified in the same endothelial cells PMID: 28058676
  38. The effects of oleuropein (OL) on hydrogen peroxide-induced oxidative stress in L02 cells showed that SOD1, GPx1, and catalase levels were all increased, and suggested that OL is a potent antioxidant and may be therapeutically useful in liver disease prevention. PMID: 27914828
  39. There were significant differences in the TT genotype distribution of the -21A>T polymorphism in the CAT gene between the tympanosclerosis and control groups, and between the chronic otitis media and control groups. PMID: 27534583
  40. The purpose of the study was to evaluate the plasma level of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) and the association between polymorphic variants in genes encoding for GPx1, SOD, CAT and the risk of distal symmetric polyneuropathy in type 2 diabetes mellitus patients. PMID: 26674569
  41. Among acute kidney injury patients in the Turkish population, hospital morbidity and mortality were found to be more frequent in patients bearing a T allele of the rs769217 polymorphism of the CAT gene. PMID: 26787049
  42. This study indicates that catalase C-262T polymorphism is associated with the endometriosis. PMID: 25154023
  43. Our results suggest that 389C>T may not contribute to vitiligo susceptibility. PMID: 25139332
  44. CAT rs1001179 polymorphism could be used to identify children that have a higher susceptibility to cerebral palsy after perinatal Hypoxic-ischaemic perinatal brain injury PMID: 27302388
  45. Increasing the endogenous NO level causes catalase inactivation and reactivation of intercellular apoptosis signaling specifically in tumor cells. PMID: 26342455
  46. In patients with chronic hepatitis C, the GPX1 Pro198Leu polymorphism, alone or combined with the CAT C-262T, was associated with high risk of fibrosis severity and hepatocellular carcinoma (HCC). In addition, GPX1 polymorphism was also associated with advanced stages of HCC. PMID: 26990426
  47. Deciphering the molecular mechanisms that regulate catalase expression could, therefore, be of crucial importance for the future development of pro-oxidant cancer chemotherapy. PMID: 26117330
  48. Study shows that the SOD2 16C/T and CAT -21A/T alleles may serve as useful genetic susceptibility markers for migraine PMID: 25818327
  49. the ratios SOD2/catalase and SOD2/Gpx1 could be considered as potential markers during progression from tumor growth to metastasis PMID: 25866291
  50. This study identified CAT is a Noise-induced hearing loss susceptibility gene when noise exposure levels are taken into account. PMID: 26045794

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Involvement in disease Acatalasemia (ACATLAS)
Subcellular Location Peroxisome
Protein Families Catalase family
Database Links

HGNC: 1516

OMIM: 115500

KEGG: hsa:847

STRING: 9606.ENSP00000241052

UniGene: Hs.502302

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