Recombinant Human Catenin delta-2 (CTNND2), partial

1. Data provide evidence that delta-catenin may serve an important role in the malignancy of lung adenocarcinoma through activation of canonical Wnt signaling and cancer stem cell maintenance. PMID: 29251319
2. Gene Ontology analysis revealed that neuronal differentiation-related genes were enriched among targets that were co-regulated by REST and TRIM28, while the level of CTNND2 was increased by the knockdown of REST and TRIM28. Consistently, during neuronal differentiation, the level of CTNND2 increased while those of REST and TRIM28 decreased, suggesting that CTNND2 expression may be co-regulated by both. PMID: 27976729
3. We propose CTNND2 as the causal gene infamilial cortical myoclonic tremor and epilepsy-3 PMID: 29127138
4. At the molecular level, CTNND2 is at the crossroad with interactions to such signaling pathways of Wnt and Rho family small GTPases in the Ras superfamily, which are known to drive human disease pathogenesis. PMID: 27380241
5. Our data suggested that genetic variants in GRM6 are associated with high myopia. The mechanism of GRM6 in the development of high myopia need to be further investigated. PMID: 27034204
6. Multigenerational autosomal dominant inheritance of 5p chromosomal deletions resulting in Cri-du-Chat Syndrome with SEMA5A, CTNND2, and ICE1 deficiencies has been described. PMID: 26601658
7. the effect of CTNND2 polymorphisms on normal variability and identified a polymorphism (rs2561622) with significant effect on phonological ability and white matter volume in the left frontal lobe, was investigated. PMID: 25473103
8. Study describes two Ion-syndromic intellectual disability cases, positive for the presence of a small copy number variants, intragenic CTNND2 gene deletion. PMID: 25839933
9. Results conclude that the introduction of CTNND2 gene variation is an important milestone in prostate cancer metabolic adaptation. PMID: 24727894
10. co-expression of Delta-catenin and RhoA was significantly associated with histological type, differentiation, pTNM stage, lymphatic metastasis and a poor prognosis in non-small cell lung cancer PMID: 25120748
11. our results suggest that delta-catenin acts as an oncoprotein when overexpressed in esophageal squamous cell carcinoma PMID: 25090917
12. SNPs in CTNND2 showed an increased signal for schizophrenia and major depressive disorder, but not for bipolar disorder. The association between CTNND2 and anxiety was not strong enough in current generation of human genome-wide analyses. PMID: 24256404
13. delta-catenin upregulates the activity of cdc42 and Rac1 GTPases at transcriptional level, and their coexpression predict a poor clinical outcome in nonsmall cell lung cancer patients PMID: 22213037
14. Genome-wide significant association with CTNND2 single nucleotide polymorphisms rs17183619, rs13155993 and rs13170756 for the bivariate outcome of cortical cataract and temporal horn volume, is reported. PMID: 22984439
15. Specific polymorphisms in the CTNND2 gene and 11q24.1 genomic region were found to be significantly associated with pathological myopia in this Chinese population. PMID: 22759899
16. Multiple genes linked to Alzheimer's disease are regulated by NPRAP. Furthermore, NPRAP nuclear translocation is required for gene regulation. PMID: 21811021
17. These results confirmed the strong association between CTNND2 polymorphism and myopia. PMID: 21911587
18. The studies support coordinated regulation of delta-catenin expression by both the activating transcription factor E2F1 and repressive transcription factor Hes1 in prostate cancer progression. PMID: 21106062
19. This study identified a strong association of CTNND2 for high myopia in Asian datasets. The CTNND2 gene maps to a known high myopia linkage region on chromosome 5p15. PMID: 21095009
20. The delta catenin is essential for N-cadherin-mediated formation of proper junctional structures and thereby the establishment of the cell polarity. PMID: 20859058
21. Cells overexpressing delta-catenin have less p120-catenin than control cells at the cell-cell interface, causing the relocalization of p120-catenin from the plasma membrane to the cytosol. CTNND2 binding to E-cadherin adversely affects CTNND1 stability. PMID: 20108168
22. Data report that either Pax6(+5a) or Pax6(-5a) was sufficient to promote, whereas their knockdown reduced the expression of delta-catenin (CTNND2), a neural specific member of the armadillo/beta-catenin superfamily. PMID: 20074565
23. Increased expression of delta-catenin is associated with the down-regulation and redistribiution of ECAD and p120ctn in prostatic cancer. PMID: 16226102
24. The interaction of scaffolding proteins with cadherin-NPRAP complexes anchors diverse signaling and adhesion molecules at cadherins. PMID: 17687028
25. These studies identify E2F1 as a positive transcriptional regulator for delta-catenin. PMID: 18302937
26. Increased nucleotide polymorphic changes in the 5'-untranslated region of delta-catenin (CTNND2) gene in prostate cancer. PMID: 18978817

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HGNC: 2516

OMIM: 604275

KEGG: hsa:1501

STRING: 9606.ENSP00000307134

UniGene: Hs.314543