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Recombinant Human Centromere protein C (CENPC CENPC1 ICEN7)

Code CSB-YP005207HU
MSDS
MSDS Datasheet
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Source Yeast
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Code CSB-EP005207HU
MSDS
MSDS Datasheet
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Source E.coli
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Code CSB-EP005207HU-B
MSDS
MSDS Datasheet
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP005207HU
MSDS
MSDS Datasheet
Size Pls inquire
Source Baculovirus
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Code CSB-MP005207HU
MSDS
MSDS Datasheet
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
CENPC
Uniprot No.
Q03188
Alternative Names
Centromere protein C; CENP-C; Centromere autoantigen C; Centromere protein C 1; CENP-C 1; Interphase centromere complex protein 7; CENPC CENPC1 ICEN7
Species
Homo sapiens (Human)
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Protein FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Related Products

CENPC Antibodies

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Target Background

Function
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions.
Gene References into Functions
  1. Whereas CENP-C recruits a single MIS12:NDC80 complex, the authors show here that CENP-T binds one MIS12:NDC80 and two NDC80 complexes upon phosphorylation by the mitotic CDK1:Cyclin B complex at three distinct CENP-T sites. PMID: 28012276
  2. CENP-C specifically binds alpha satellite non-coding RNAs. PMID: 28787590
  3. A nonhistone centromere protein, CENP-C, binds and reshapes the nucleosome, sliding the DNA gyres back to positions similar to those in canonical nucleosomes containing conventional histone H3. PMID: 26878239
  4. HPV18 E7 inhibited the binding of CENP-C to alpha-satellite DNAs. PMID: 25997930
  5. CENP-C recruits the Ndc80 complex through its interactions with KNL1 and the Mis12 complex at kinetochores during chromosome segregation. PMID: 25660545
  6. CENP-C, a CCAN subunit, is crucial for kinetochore assembly because it links centromeres with the microtubule-binding interface of kinetochores. PMID: 26124289
  7. CENP-C affects nucleosome shape and dynamics in a manner analogous to allosteric regulation of enzymes. CENP-C depletion leads to rapid removal of CENP-A from centromeres, indicating their collaboration in maintaining centromere identity. PMID: 25954010
  8. CENP-C works as an important factor for centromeric M18BP1 recruitment PMID: 22540025
  9. Direct binding of Cenp-C to the Mis12 complex joins the inner and outer kinetochore. PMID: 21353556
  10. CENP-C may target the centromere by establishing multiple contacts with both the DNA and protein constituents of the kinetochore PMID: 12490152
  11. CENPC target sites that can be sumoylated by SUMO-2 were shown to be equally susceptible to SUMO-1 attachments which include specific sites on SUMO-2 itself, Ubc9, and the recombinant CENP-C fragments PMID: 15272016
  12. a functional interplay between the chromosomal passenger complex and CENP-C. PMID: 17287400
  13. Using protein truncation and in vitro mutagenesis, we have identified the nucleolar localization sequences on CENPC1,and evidence shows that CENPC1 is an RNA-associating protein that binds alpha-satellite RNA by an in vitro binding assay. PMID: 17623812
  14. CENP-C and CENP-H co-localize to the CENP-A chromatin domain. PMID: 17651496
  15. DNMT3B interacts with CENP-C to modulate DNA methylation and the histone code at centromere. PMID: 19482874
  16. C-terminal domain of CENP-C displays multiple and critical functions for mammalian centromere formation PMID: 19503796

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Subcellular Location
Nucleus. Chromosome, centromere, kinetochore. Chromosome, centromere.
Protein Families
CENP-C/MIF2 family
Database Links

HGNC: 1854

OMIM: 117141

KEGG: hsa:1060

STRING: 9606.ENSP00000273853

UniGene: Hs.479867

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CUSABIO's Five Expression Systems General Information of Different Tags How to express a protein with bioactivity? How to choose a suitable expression vector? Applications of recombinant proteins Production of Recombinant Protein
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