CENPC Antibody

1. Whereas CENP-C recruits a single MIS12:NDC80 complex, the authors show here that CENP-T binds one MIS12:NDC80 and two NDC80 complexes upon phosphorylation by the mitotic CDK1:Cyclin B complex at three distinct CENP-T sites. PMID: 28012276
2. CENP-C specifically binds alpha satellite non-coding RNAs. PMID: 28787590
3. A nonhistone centromere protein, CENP-C, binds and reshapes the nucleosome, sliding the DNA gyres back to positions similar to those in canonical nucleosomes containing conventional histone H3. PMID: 26878239
4. HPV18 E7 inhibited the binding of CENP-C to alpha-satellite DNAs. PMID: 25997930
5. CENP-C recruits the Ndc80 complex through its interactions with KNL1 and the Mis12 complex at kinetochores during chromosome segregation. PMID: 25660545
6. CENP-C, a CCAN subunit, is crucial for kinetochore assembly because it links centromeres with the microtubule-binding interface of kinetochores. PMID: 26124289
7. CENP-C affects nucleosome shape and dynamics in a manner analogous to allosteric regulation of enzymes. CENP-C depletion leads to rapid removal of CENP-A from centromeres, indicating their collaboration in maintaining centromere identity. PMID: 25954010
8. CENP-C works as an important factor for centromeric M18BP1 recruitment PMID: 22540025
9. Direct binding of Cenp-C to the Mis12 complex joins the inner and outer kinetochore. PMID: 21353556
10. CENP-C may target the centromere by establishing multiple contacts with both the DNA and protein constituents of the kinetochore PMID: 12490152
11. CENPC target sites that can be sumoylated by SUMO-2 were shown to be equally susceptible to SUMO-1 attachments which include specific sites on SUMO-2 itself, Ubc9, and the recombinant CENP-C fragments PMID: 15272016
12. a functional interplay between the chromosomal passenger complex and CENP-C. PMID: 17287400
13. Using protein truncation and in vitro mutagenesis, we have identified the nucleolar localization sequences on CENPC1,and evidence shows that CENPC1 is an RNA-associating protein that binds alpha-satellite RNA by an in vitro binding assay. PMID: 17623812
14. CENP-C and CENP-H co-localize to the CENP-A chromatin domain. PMID: 17651496
15. DNMT3B interacts with CENP-C to modulate DNA methylation and the histone code at centromere. PMID: 19482874
16. C-terminal domain of CENP-C displays multiple and critical functions for mammalian centromere formation PMID: 19503796

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HGNC: 1854

OMIM: 117141

KEGG: hsa:1060

STRING: 9606.ENSP00000273853

UniGene: Hs.479867