Recombinant Human Cullin-5 (CUL5)

1. CUL5 may be an important part of the mechanism for thalidomide-dependent inhibition. PMID: 29746508
2. These findings report genetic variants possibly associated with susceptibility to HIV-1 infection (CUL5 rs11212495, rs7103534, rs7117111) and partial viral load control (APOBEC3G rs2294367). PMID: 28302043
3. structural model suggests that the diverse FIV and HIV-1 Vifs use conserved residues for Cullin 5 binding, FIV Vif binds Cullin 5 independently of zinc, in contrast to HIV-1 Vif. PMID: 29263270
4. these findings identify Cul-5 as a signaling component that connects an LPS-activated TLR4-MyD88 complex to TRAF6 for efficient activation of NF-kappaB PMID: 27233966
5. CUL5 neddylation may allosterically tune polyubiquitin chain length and topology. PMID: 28082425
6. Study found that CUL5 expression was significantly decreased in both endometrioid adenocarcinomas with the more aggressive serous type displaying a higher reduction. Its mRNA and protein overexpression in endometrial cancer cells resulted in decreased cell proliferation. PMID: 26847831
7. Studies indicate that Cullin-RING E3 ubiquitin ligases (CRL) are key players of the ubiquitylation pathway. PMID: 26253693
8. These results provide important information on the assembly of the Vif-CUL5-E3 ubiquitin ligase and identify a new viV binding interface with CBF-beta at the C-terminus of HIV-1 Vif. PMID: 25424878
9. Data indicate that cell surface adhesion molecules VCAM-1 and P-selectin play some roles in mechanical stretch-induced HL-60 cell adhesion to mouse common carotid arteries. PMID: 25108430
10. N-terminal mutants of HIV-1 vif that demonstrated reduced Cul5 binding were also unable to degrade APOBEC3G as well as APOBEC3F. PMID: 24422669
11. A tumor suppressor gene, CUL5, is identified as a direct target of miR-7 in hepatocellular carcinoma. PMID: 24339204
12. Silencing CUL5 reduced cellular sensitivity to three distinct HSP90 inhibitors, across four cancer types driven by different protein kinases. PMID: 24760825
13. In the absence of CBFbeta, Vif does not bind Cul5, thus preventing the assembly of the E3 ligase complex. PMID: 24390320
14. CBF-beta is critical for the formation of the Vif-ElonginB/ElonginC-Cul5 core E3 ubiquitin ligase complex. PMID: 24390335
15. data reveal the structural basis for Vif hijacking of the CBF-beta and CUL5 E3 ligase complex, laying a foundation for rational design of novel anti-HIV drugs PMID: 24402281
16. ASB9 is unstable alone but forms a stable ternary complex with EloBC that binds with high affinity to the Cullin 5 N-terminal domain. PMID: 23837592
17. crystal structure shows interaction between SOCS2-elongin BC and Cullin-5 PMID: 23897481
18. Data indicate tht n the Biaka, strong signal of selection was detected at CUL5 and at TSG101. PMID: 23217182
19. comparison of heat capacity changes supports a model in which CBFbeta prestabilizes Vif((1-192)) relative to Vif((95-192)), consistent with a stronger interaction of Cul5 with Vif's C-terminal Zn(2+)-binding motif. PMID: 23098073
20. detected a reduced editing associated with the CUL5 SNP6 minor allele and also with certain Vif variants (mutations at sites 46, 122, and 160). PMID: 22145963
21. Vif alterations may contribute to a rapid AIDS onset and Vif variability could be influenced by APOBEC3G and CUL5 polymorphisms in children PMID: 21571098
22. study showed VACM-1 DNA in T47D cancer cells is not mutated; SNP found in U138MG, OVCAR-3 and ACHN cell lines results in silent mutation; results suggest in T47D cancer cells, VACM-1 activity may controlled by epigenetic or posttranslational modification PMID: 21635549
23. Cul5 interacts with the Hsp90 chaperone complex and is recruited to the site of ErbB2 on the plasma membrane, thereby inducing its polyubiquitination and proteasome-mediated degradation. PMID: 19933325
24. findings report that HIV-1 Vif interacts with cellular proteins Cul5, elongins B and C, and Rbx1 to form an Skp1-cullin-F-box (SCF)-like complex PMID: 14564014
25. These data indicate that vasopressin-activated calcium-mobilizing (VACM-1) is involved in the regulation of cellular growth. PMID: 15184056
26. Cul5 promotes vif ubiquination and requires intact SOCS-box PMID: 15574592
27. the E3 ubiquitin ligase activity of the Vif-BC-Cul5 complex is essential for Vif function against APOBEC3G PMID: 15781449
28. findings indicate that the assembly of Vif-Cul5 E3 ubiquitin ligases requires a hydrophobic interface within a novel zinc-binding domain in the substrate receptor Vif and a unique region in Cul5 PMID: 16530799
29. the zinc-binding region in Vif is a novel cullin interaction domain that mediates selective binding to Cul5 PMID: 16636053
30. Data indicate that in the T47D cancer cell line VACM-1 inhibits growth by attenuating estrogen-dependent/estrogen receptor alpha signaling responses. PMID: 17186378
31. Adenovirus E4orf6-mediated p53 degradation requires Cul5. PMID: 17351129
32. CUL5, together with NPAT and PPP2R1B, is implicated in the deregulation of the cell-cycle and apoptosis regulators and in the pathogenesis of B-CLL. PMID: 17449237
33. Cul5 plays an essential role in regulating neuron migrations during cortical development, possibly by opposing a promigratory effect of Dab1. PMID: 17974915
34. Degradation of AAV5 proteins can be inhibited by a dominant-negative ubiquitin that prevents chain elongation or by small interfering RNA directed against cullin 5. PMID: 18216112
35. The purpose of this study was to determine if there is increased expression of Cul5 during granulocytic differentiation of HL-60 cells. PMID: 19118439
36. HIV-1 virion infectivity factor (Vif) protein-cullin 5 (Cul5) interaction is mediated by zinc binding to the conserved Vif HCCH motif. Zinc enhances the Vif HCCH-Cul5 interaction by 8-fold. PMID: 19588889

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HGNC: 2556

OMIM: 601741

KEGG: hsa:8065

STRING: 9606.ENSP00000376808

UniGene: Hs.440320