Recombinant Human Cyclin-dependent kinase-like 3(CDKL3)

Code CSB-YP005083HU
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Source Yeast
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Code CSB-EP005083HU
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Source E.coli
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Code CSB-EP005083HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP005083HU
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Source Baculovirus
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Code CSB-MP005083HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names CDKL3
Uniprot No. Q8IVW4
Alternative Names CDKL3; CDKL3 protein; CDKL3_HUMAN; Cyclin dependent kinase like 3; Cyclin-dependent kinase-like 3; Serine/threonine-protein kinase NKIAMRE
Species Homo sapiens (Human)
Expression Region 1-592
Target Protein Sequence MEMYETLGKV GEGSYGTVMK CKHKNTGQIV AIKIFYERPE QSVNKIAMRE IKFLKQFHHE NLVNLIEVFR QKKKIHLVFE FIDHTVLDEL QHYCHGLESK RLRKYLFQIL RAIDYLHSNN IIHRDIKPEN ILVSQSGITK LCDFGFARTL AAPGDIYTDY VATRWYRAPE LVLKDTSYGK PVDIWALGCM IIEMATGNPY LPSSSDLDLL HKIVLKVGNL SPHLQNIFSK SPIFAGVVLP QVQHPKNARK KYPKLNGLLA DIVHACLQID PADRISSSDL LHHEYFTRDG FIEKFMPELK AKLLQEAKVN SLIKPKESSK ENELRKDERK TVYTNTLLSS SVLGKEIEKE KKPKEIKVRV IKVKGGRGDI SEPKKKEYEG GLGQQDANEN VHPMSPDTKL VTIEPPNPIN PSTNCNGLKE NPHCGGSVTM PPINLTNSNL MAANLSSNLF HPSVRLTERA KKRRTSSQSI GQVMPNSRQE DPGPIQSQME KGIFNERTGH SDQMANENKR KLNFSRSDRK EFHFPELPVT IQSKDTKGME VKQIKMLKRE SKKTESSKIP TLLNVDQNQE KQEGGDGHCE GKNLKRNRFF FW
Protein Length full length protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Gene References into Functions
  1. NKIAMRE is a member of a conserved family of kinases with homology to both MAP kinases and cyclin-dependent kinases PMID: 12927787
  2. cdkl3 transfected in anchorage-independent (suspension) HeLa cells overexpressed relative to attached cells and lead to elevated proliferation and faster transition G0/G1 phases to S phase relative to controls. Same in two HEK-293 and a CHO cell lines. PMID: 17945021
  3. data suggest that the CDKL3 gene is a strong candidate for nonsyndromal autosomal dominant mild mental retardation PMID: 18412109
Subcellular Location Cytoplasm
Protein Families Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
Database Links

HGNC: 15483

OMIM: 608459

KEGG: hsa:51265

STRING: 9606.ENSP00000265334

UniGene: Hs.719926

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