Recombinant Human D-dopachrome decarboxylase (DDT)

1. D-dopachrome tautomerase transcription may be regulated in a cell-dependent manner, and was enhanced by AMPK activation in SGBS adipocytes through inhibiting the mTOR signaling PMID: 28445821
2. The knockdown of D-DT and MIF, individually and additively, inhibited the proliferation, migration, and invasion in HeLa and SiHa cells and restrained the growth of xenograft tumor. PMID: 28338494
3. These results have implications for the manner in which D-DT and MIF compete with each other for binding to the CD74 receptor and for the relative potency of DRa1-MOG-35-55 and RTL1000 for competitive inhibition of D-DT and MIF binding and activation through CD74. PMID: 27573366
4. Study demonstrated that DDT was over- expressed in pancreatic ductal adenocarcinoma (PDAC) tissues and cell lines in a pattern correlated with MIF, and knockdown of DDT and MIF in PANC- 1 cells cooperatively inhibited cell proliferation, invasion and tumor formation. The tautomerase activities of both MIF and DDT are required for their negative regulatory role in p53 and their tumor-promoting functions. PMID: 27434219
5. DDT was increased in burn patients. PMID: 27209369
6. Gene expression level of DDT is significantly higher in AD patients when compared to normal controls. PMID: 26943237
7. High MIF-2 levels are predictive of the development of organ dysfunction in myocardial ischemia reperfusion injury. PMID: 26234719
8. Both p53 wildtype and mutant human lung adenocarcinoma tumors rely on MIF family members for maximal cell growth and survival. PMID: 24932684
9. findings identify DDT as a functionally redundant but more potent cytokine to MIF in cancer and suggest that current attempts to inhibit MIF signaling may fail because of DDT compensation. PMID: 24356968
10. D-dopachrome tautomerase secreted from adipocytes acts on preadipocytes to promote IL-6 expression and to inhibit adipogenesis by suppressing the induction of genes encoding adipogenic regulators PMID: 22951300
11. DDT acts on adipocytes to regulate lipid metabolism through AMPK and/or PKA pathway(s) and improves glucose intolerance caused by obesity. PMID: 22428043
12. These data indicate that D-DT is a MIF-like cytokine. PMID: 21817065
13. D-DT-dependent beta-catenin stabilization is regulated by COX-2 expression, suggesting the existence of an amplification loop between COX-2- and beta-catenin-mediated transcription in these cells PMID: 21071513
14. role of tautomerase active site of macrophage migration inhibitory factor as a potential target for discovery of novel anti-inflammatory agents PMID: 11997397
15. DDT is for the first time demonstrated in the skin and can be related to inflammation, and its covariation with MIF strengthens this observation. PMID: 12823441
16. D-dopachrome tautomerase (D-DT) and macrophage migration inhibitory factor, individually and additively, promote vascular endothelial growth factor and CXCL8 expression in human lung adenocarcinoma cell lines. PMID: 18684922

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HGNC: 2732

OMIM: 602750

KEGG: hsa:1652

STRING: 9606.ENSP00000215773

UniGene: Hs.656723