Recombinant Human DNA mismatch repair protein Msh3 (MSH3), partial

1. The role of MSH3 in 11 Lynch Syndrome patients with truncating MSH6 germline variants and an unexplained MSH2 protein loss.Heterozygous MSH3 defects alone do not seem to induce a Lynch Syndrome phenotype PMID: 28528517
2. MSH3 was frequently inactivated by promoter methylation and its mRNA and protein expression correlated with the primary tumor stage in nasopharyngeal carcinoma. PMID: 28656302
3. Msh3-/- cells are severely defective for CTG*CAG repeat expansions but show full activity on contractions. Msh3 overexpression led to high expansion activity and elevated levels of MutSbeta complex, indicating that MutSbeta abundance drives expansions. Expression of 2 Msh3 polymorphic variants at normal levels showed no detectable change in expansions. These polymorphisms primarily affect Msh3 protein stability, not ac... PMID: 28973443
4. MSH3 is probably a modifier of disease progression in Huntington's disease. PMID: 28642124
5. data suggest that MSH3 mutations represent an additional recessive subtype of colorectal adenomatous polyposis PMID: 27476653
6. Three polymorphisms in MSH3 were associated with variation in somatic instability in myotonic dystrophy type 1. PMID: 26994442
7. Our meta-analysis results demonstrated that MSH3 rs26279 G > A polymorphism is associated with an increased risk of overall cancer, especially for the colorectal cancer and breast cancer. PMID: 26617824
8. Data show that single nucleotide polymorphisms in MutS homolog 3 (MSH3) had an impact on the chemotherapy response and prognosis of advanced non-small cell lung cancer (NCSLC) patients who were treated with platinum-based chemotherapy. PMID: 25966119
9. IL6 signaling disrupts the nuclear localization of hMSH3 and DNA repair, leading to elevated microsatellite alterations at selected tetranucleotide repeats in cancer cell lines. PMID: 25461668
10. Methylation of MSH3 together with exposure to tobacco smoke is involved in esophageal carcinogenesis. PMID: 24934723
11. MSH3 status can regulate the DNA damage response and extent of apoptosis induced by chemotherapy. PMID: 23724141
12. Single nucleotide polymorphisms in MSH3 are associated with myelodysplastic syndromes. PMID: 23339595
13. Oxidative stress, which causes a shift of hMSH3's subcellular location, may contribute to an hMSH3 loss-of-function phenotype by sequestering it to the cytosol PMID: 23226332
14. The binding of HIF-1alpha complexes to hypoxia response element sites is necessary for down-regulation of hMSH3 in both wt-p53 and mut-p53 cells. PMID: 22343000
15. The high frequency of loss of heterozygosity as well as the aberrant protein expression in some tumors indicates an involvement of MSH3 impairment in colorectal cancer with low-level microsatellite instability. PMID: 22249440
16. polymorphisms in MSH3 do not contribute to cancer risk in a population of Lynch syndrome patients with colorectal cancer PMID: 21974800
17. two novel HLA-A0201-restricted cytotoxic T cell epitopes derived from a (-1) frameshift mutation of a coding A(8) tract within the MSH3 gene PMID: 22110587
18. We hypothesise a model in which variants of the MSH3 gene behave as low-risk alleles that contribute to the risk of colon cancer in Lynch families, mostly with other low-risk alleles of MMR genes. PMID: 21128252
19. Stress treatment of mouse cells with ethanol or hydrogen peroxide caused the re-distribution of MSH3 into nuclear bodies containing the proliferating cell nuclear antigen (PCNA), a known binding partner of MutSbeta. PMID: 21344488
20. Results provide novel evidence that MSH3 deficiency contributes to the cytotoxicity of platinum drugs through deficient DSB repair. PMID: 21285347
21. Nondysplastic epithelium from hamartomatous polyposis syndrome polyps harbors hMSH3 defects, which may prime neoplastic transformation. PMID: 20845481
22. No association of tumor necrosis with expression of p53, bcl-2, and mismatch repair protein status was observed in colorectal cancers. PMID: 20869096
23. Loss of hMSH3 corresponds with multiple tetranucleotide frameshifts. The association between EMAST and ulcerated tumors might result from increased inflammation. PMID: 20708618
24. Endoscopic biopsy provides equal accuracy and easier interpretation of MMRP expression immunostaining compared to surgical resection specimens. PMID: 20632816
25. This is the first report suggesting that genetic and epigenetic alterations in the human MSH3 gene might play a significant role in the progression of bladder tumors. PMID: 15541380
26. Plays a key role in the formation of CTG repeat expansions over successive generations in DM1 transgenic mice. PMID: 16552576
27. Polymorphisms in the mismatch repair gene, MSH3 is associated with colorectal cancer PMID: 17205513
28. Alterations in TGF-betaRII, BAX, IGFIIR, caspase-5, hMSH3 and hMSH6 genes of microsatellite instability are rare in urinary bladder carcinoma and they are not associated with microsatellite instability or the presence of p53 mutations. PMID: 17676485
29. Mutations at the mononucleotide repeats within the hMSH3 gene occurred in certain basal cell carcinomas, not always in association with microsatellite instability . PMID: 17950544
30. Mismatch repair gene MSH3 polymorphism is associated with the risk of sporadic prostate cancer PMID: 18355840
31. Genetic instability caused by loss of MutS homologue 3 in human colorectal cancer. PMID: 18922920

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HGNC: 7326

OMIM: 600887

KEGG: hsa:4437

STRING: 9606.ENSP00000265081

UniGene: Hs.280987