Recombinant Human DnaJ homolog subfamily B member 6 (DNAJB6)

1. DNAJB6 is a central and versatile player in the protein aggregation and degradation system.DNAJB6 protein keeps Parkin C289G mutant protein in a soluble, degradation-competent form. PMID: 27713507
2. This study expands the molecular spectrum of DNAJB6 mutations and also emphasizes the pathogenic role of DNAJB6 dysfunction in distal-onset myopathy. PMID: 28233300
3. Expression of the heat shock protein DNAJB6/MRJ was elevated in neutrophils and lymphocytes of patients with atopic dermatitis compared with healthy donors. The highest level of the DNAJB6/MRJ protein was found to be in neutrophils at acute phase of severe atopic dermatitis and gradually decline as continue to the disease. PMID: 29244458
4. mRNA levels of HSP family members (HSP70B', HSP72, HSP40/DNAJ, and HSP20/CRYAB) are upregulated by the intracellular MMP3 overload. PMID: 27206651
5. the cytoprotective effects of DNAJB6(S) may be mediated, at least in part, by the mitochondrial pathway of apoptosis. PMID: 28280525
6. The results indicate both genetic and physical interactions between disease-linked RNA-binding proteinss and DNAJB6/mrj, suggesting etiologic overlap between the pathogenesis of adult-onset inherited myopathies initiated by mutations in hnRNPA2B1 and DNAJB6. PMID: 26744327
7. LGMD1D mutations in DNAJB6 disrupt its sarcoplasmic function suggesting a role for DNAJB6b in Z-disc organization and stress granule kinetics. PMID: 26362252
8. DNAJB6 mutations p.F91I and p.F91L show a significant reduction of the anti-aggregation function compared to the wild-type and p.F93L mutation PMID: 26338452
9. Functional study using zebrafish embryos demonstrated that p.Phe91Leu elicits more severe muscle defects than the reported p.Phe93Leu and p.Pro96Arg mutations PMID: 26371419
10. DnaJB6-protected yeast cells from polyglutamine toxicity and cured yeast of both [URE3] prions and weak variants of [PSI(+)] prions but not strong [PSI(+)] prions PMID: 26702057
11. This study showed that Complete loss of the DNAJB6 G/F domain and novel missense mutations cause distal-onset DNAJB6 myopathy. PMID: 26205529
12. DNAJB6a reduces AKT signaling, and DNAJB6 expression in cancer cells reduces their proliferation and growth of xenograft esophageal squamous cell tumors in mice. PMID: 26302489
13. There was a positive correlation between DNAJB6 and IQGAP1 expression. PMID: 25044025
14. Geneticanalysis indicated a heterozygous missense mutation of c.279C>G PMID: 25306414
15. Findings suggest a novel function of HSP70/MRJ/uPAR complex in cell adhesion, invasion and migration, and may provide more understanding in the mechanisms of uPAR-mediated cancer metastasis. PMID: 25175595
16. DNAJB6 G/F domain mutants disrupt the processing of nuclear TDP-43 stress granules in mammalian cells. PMID: 24920671
17. DNAJB6 interacts with growing amyloid-beta 42 (Abeta42) aggregates, which leads to sub-stoichiometric inhibition of amyloid formation PMID: 25217638
18. using exome sequencing, study identified a mutation in DNAJB6 in a family with limb-girdle muscular dystrophy type 1D; work further confirms the causative role of DNAJB6 mutations in limb-girdle muscular dystrophy type 1D PMID: 24594375
19. DNAJB6 is a peptide-binding chaperone that can interact with polyQ peptides that are incompletely degraded by and released from the proteasome. PMID: 23904097
20. have previously reported clinical, genetic and molecular pathomechanistic findings in DNAJB6 mutated LGMD1D PMID: 23865856
21. A 56-year-old woman, like 3 other family members, becomes symptomatic in childhood with slowly progressive limb-girdle muscle weakness, normal serum creatine kinase (CK) values, and myopathic electromyographic findings. PMID: 24170373
22. We identified DNAJ/HSP40B6 as a potential negative regulator of HIV-1 replication in our genetic screens. PMID: 24047968
23. we detected cytoplasmic accumulations associated with chaperone-assisted selective autophagy together with intranuclear accumulations of DNAJB6 and HSPB8. This is the first report of Asian patients with limb-girdle muscular dystrophy type 1D PMID: 23394708
24. The mechanism of DNAJB6 and DNAJB8 is suppression of polyQ protein aggregation by directly binding the polyQ tract. PMID: 23612975
25. the relative expression levels of DNAJB6 isoforms may play a key role in regulating the cellular localization of UL70, leading to modulation of HCMV DNA synthesis and lytic infection. PMID: 23133382
26. miR-632 is a potentially important epigenetic regulator of DNAJB6, which contributes to the downregulation of DNAJB6 and plays a supportive role in malignant progression PMID: 22710984
27. A novel regulatory mechanism for DNAJB6-mediated DKK1 transcriptional up-regulation might influence epithelial-mesenchymal transition. PMID: 22455953
28. MRJ (short form) shows nuclear localization signal independent nuclear localization in response to heat shock and hypoxia. PMID: 22504047
29. studied 9 Limb-girdle muscular dystrophy type 1D affected families from Finland, the United States and Italy and identified 4 dominant missense mutations leading to p.Phe93Leu or p.Phe89Ile changes in the co-chaperone DNAJB6 PMID: 22366786
30. Mutations within the Pro96Arg domain of DNAJB6 are a novel cause of dominantly-inherited myopathy. PMID: 22334415
31. the interaction between urokinase receptor and heat shock protein MRJ enhances cell adhesion PMID: 20372789
32. DNAJB6 induces degradation of beta-catenin and causes partial reversal of mesenchymal phenotype PMID: 20522561
33. DNAJB6b and DNAJB8 are superior suppressors of aggregation and toxicity of disease-associated polyglutamine proteins. PMID: 20159555
34. MRJ has a relevant functional role in neurons. PMID: 11896048
35. Role of Hsp40 co-chaperone Hdj-1 in CFTR turnover with HSP70 PMID: 12069690
36. NFATc3 is negatively regulated by class II histone deacetylases through the DnaJ (heat shock protein-40) superfamily member Mrj PMID: 16260608
37. msj-1 gene might be conserved among vertebrates and might exert fundamental functions in reproduction. PMID: 18184612
38. Large isoform of MRJ(L), DNAJB6, is a nuclear protein that is lost in breast cancer, that regulates several key players in tumor formation and metastasis, and that is functionally able to retard tumor growth. PMID: 18328103
39. DnaJB6 is necessary for translocation of Slfn1 into the nucleus, where Slfn1 down-regulates cyclin D1, induces cell-cycle arrest and programmes a quiescent state of T-cells PMID: 18373498
40. we report the up-regulation of Mrj protein in M-phase of HeLa cells implicating its role in mitosis related activities. PMID: 19002655

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HGNC: 14888

OMIM: 603511

KEGG: hsa:10049

STRING: 9606.ENSP00000262177

UniGene: Hs.188591