Recombinant Human Dual serine/threonine and tyrosine protein kinase (DSTYK), partial

Code CSB-YP007213HU
MSDS
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Source Yeast
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Code CSB-EP007213HU
MSDS
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Source E.coli
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Code CSB-EP007213HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP007213HU
MSDS
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Source Baculovirus
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Code CSB-MP007213HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
DSTYK
Uniprot No.
Alternative Names
DSTYK; Dual serine/threonine and tyrosine protein kinase; Dusty PK; Dusty protein kinase; DUSTY_HUMAN; HDCMD38P; KIAA0472; Receptor interacting protein 5; Receptor interacting protein kinase 5; Receptor interacting serine/threonine protein kinase 5; Receptor-interacting serine/threonine-protein kinase 5; RIP homologous kinase; RIP-homologous kinase; RIP5; RIPK5; SgK496; Sugen kinase 496
Species
Homo sapiens (Human)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types.
Gene References into Functions
  1. RIPK3 promotes adenovirus type 5 oncolytic activity. PMID: 29238045
  2. we identified a complex homozygous 4-kb deletion/20-bp insertion in DSTYK in all four affected family members with Autosomal-Recessive Complicated Spastic Paraparesis, SPG23 PMID: 28157540
  3. We detected independent DSTYK mutations in 2.3% of patients with congenital abnormalities of the kidney or urinary tract, a finding that suggests that DSTYK is a major determinant of human urinary tract development, downstream of FGF signaling. PMID: 23862974
  4. Confocal imaging of transiently expressed human Dusty-GFP fusion proteins showed a cytoplasmic distribution. PMID: 17123648
Involvement in disease
Congenital anomalies of the kidney and urinary tract 1 (CAKUT1); Spastic paraplegia 23 (SPG23)
Subcellular Location
Cytoplasm. Cell membrane. Apical cell membrane. Basolateral cell membrane. Cell junction.
Protein Families
Protein kinase superfamily, Ser/Thr protein kinase family
Tissue Specificity
Predominantly expressed in skeletal muscle and testis. Expressed in basolateral and apical membranes of all tubular epithelia. Expressed in thin ascending limb of the loop of Henle and the distal convoluted tubule. Expressed in all layers of transitional
Database Links

HGNC: 29043

OMIM: 270750

KEGG: hsa:25778

STRING: 9606.ENSP00000356130

UniGene: Hs.6874

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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