DSTYK Antibody

Datasheet

Code	CSB-PA846981
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA846981(DSTYK Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200) Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: 823 cells, hepg2 cells, Primary antibody: CSB-PA846981(DSTYK Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
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Product Details
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Target Background

Product Details

Uniprot No.

Q6XUX3

Target Names

DSTYK

Alternative Names

DSTYK antibody; Dual serine/threonine and tyrosine protein kinase antibody; Dusty PK antibody; Dusty protein kinase antibody; DUSTY_HUMAN antibody; HDCMD38P antibody; KIAA0472 antibody; Receptor interacting protein 5 antibody; Receptor interacting protein kinase 5 antibody; Receptor interacting serine/threonine protein kinase 5 antibody; Receptor-interacting serine/threonine-protein kinase 5 antibody; RIP homologous kinase antibody; RIP-homologous kinase antibody; RIP5 antibody; RIPK5 antibody; SgK496 antibody; Sugen kinase 496 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Fusion protein of Human DSTYK

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,WB,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:1000-1:2000
WB	1:200-1:1000
IHC	1:25-1:100

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types.

Gene References into Functions

RIPK3 promotes adenovirus type 5 oncolytic activity. PMID: 29238045
we identified a complex homozygous 4-kb deletion/20-bp insertion in DSTYK in all four affected family members with Autosomal-Recessive Complicated Spastic Paraparesis, SPG23 PMID: 28157540
We detected independent DSTYK mutations in 2.3% of patients with congenital abnormalities of the kidney or urinary tract, a finding that suggests that DSTYK is a major determinant of human urinary tract development, downstream of FGF signaling. PMID: 23862974
Confocal imaging of transiently expressed human Dusty-GFP fusion proteins showed a cytoplasmic distribution. PMID: 17123648

Involvement in disease

Congenital anomalies of the kidney and urinary tract 1 (CAKUT1); Spastic paraplegia 23 (SPG23)

Subcellular Location

Cytoplasm. Cell membrane. Apical cell membrane. Basolateral cell membrane. Cell junction.

Protein Families

Protein kinase superfamily, Ser/Thr protein kinase family

Tissue Specificity

Predominantly expressed in skeletal muscle and testis. Expressed in basolateral and apical membranes of all tubular epithelia. Expressed in thin ascending limb of the loop of Henle and the distal convoluted tubule. Expressed in all layers of transitional

Database Links

HGNC: 29043

OMIM: 270750

KEGG: hsa:25778

STRING: 9606.ENSP00000356130

UniGene: Hs.6874

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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