Recombinant Human FERM, RhoGEF and pleckstrin domain-containing protein 1 (FARP1), partial

Code CSB-YP897492HU
MSDS
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Source Yeast
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Code CSB-EP897492HU
MSDS
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Source E.coli
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Code CSB-EP897492HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP897492HU
MSDS
Size Pls inquire
Source Baculovirus
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Code CSB-MP897492HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
FARP1
Uniprot No.
Alternative Names
CDEP; Chondrocyte derived ezrin like protein; Chondrocyte-derived ezrin-like protein; FARP1; FARP1_HUMAN; FERM RhoGEF and pleckstrin domain containing protein 1; FERM; FERM RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived); FERM; ARHGEF; and pleckstrin domain protein 1; PH domain-containing family C member 2; Pleckstrin homology domain-containing family C member 2; PLEKHC2; PPP1R75; protein phosphatase 1; regulatory subunit 75; RhoGEF and pleckstrin domain-containing protein 1
Species
Homo sapiens (Human)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses.
Gene References into Functions
  1. We have reported here for the first time a reduced activity of both Rac1 and Cdc42 in human pheochromocytoma resection as well as tumor-associated expression changes of FARP1, ARHGEF1, and ARHGAP36 PMID: 26911374
Subcellular Location
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Cell junction, synapse, synaptosome. Cytoplasm, cytosol. Cell projection, filopodium. Cell projection, dendrite. Cell projection, dendritic spine.
Tissue Specificity
Detected in cAMP-treated chondrocytes, but not in untreated chondrocytes. Detected in fetal brain, heart and spleen, and in adult testis, kidney and lung.
Database Links

HGNC: 3591

OMIM: 602654

KEGG: hsa:10160

STRING: 9606.ENSP00000322926

UniGene: Hs.403917

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