||Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity).
|Gene References into Functions
- We have reported here for the first time a reduced activity of both Rac1 and Cdc42 in human pheochromocytoma resection as well as tumor-associated expression changes of FARP1, ARHGEF1, and ARHGAP36 PMID: 26911374
||Cell membrane, Peripheral membrane protein, Cytoplasmic side, Cell junction, synapse, Cell junction, synapse, synaptosome, Cytoplasm, cytosol, Cell projection, filopodium, Cell projection, dendrite, Cell projection, dendritic spine
||Detected in cAMP-treated chondrocytes, but not in untreated chondrocytes. Detected in fetal brain, heart and spleen, and in adult testis, kidney and lung.