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Recombinant Human Fibroblast growth factor receptor 3 (FGFR3), partial (Active)

Recombinant Human Fibroblast growth factor receptor 3 (FGFR3), partial (Active)

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Code	CSB-MP008646HU1(F2)
Abbreviation	Recombinant Human FGFR3 protein, partial (Active)
MSDS	MSDS Datasheet
Size	$114
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Image	(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel. Activity Measured by its binding ability in a functional ELISA. Immobilized Human FGFR3 at 2 μg/ml can bind Anti-FGFR3 recombinant antibody (CSB-RA008646MA1HU). The EC₅₀ is 0.7264-1.525 ng/mL. Biological Activity Assay
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Product Details

Purity

Greater than 95% as determined by SDS-PAGE.

Endotoxin

Less than 1.0 EU/ug as determined by LAL method.

Activity

Measured by its binding ability in a functional ELISA. Immobilized Human FGFR3 at 2 μg/mL can bind Anti-FGFR3 recombinant antibody (CSB-RA008646MA1HU). The EC50 is 0.7264-1.525 ng/mL.

Target Names

FGFR3

Uniprot No.

P22607-2

Alternative Names

FGFR-3;CD333

Species

Homo sapiens (Human)

Source

Mammalian cell

Expression Region

23-377aa

Target Protein Sequence

ESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISESVEADVRLRLANVSERDGGEYLCRATNFIGVAEKAFWLSVHGPRAAEEELVEADEAGSVYAG

Mol. Weight

40.0 kDa

Protein Length

Partial of Isoform 2

Tag Info

C-terminal 10xHis-tagged

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer

Lyophilized from a 0.2 μm sterile filtered PBS, 6% Trehalose, pH 7.4

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

3-7 business days

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet & COA

Please contact us to get it.

Description

FGFR3 dysregulation drives oncogenesis in bladder carcinoma, multiple myeloma, and thanatophoric dysplasia, making validated extracellular domain constructs essential tools for dissecting ligand-receptor interactions and screening therapeutic candidates. This mammalian-expressed construct spanning residues 23–377 of isoform 2 captures the complete ligand-binding region and demonstrates quantifiable antibody-binding activity with an EC50 of 0.72–1.53 ng/mL in functional ELISA, providing a reliable basis for competitive inhibition assays, blocking antibody screening, and therapeutic antibody epitope mapping. The measured affinity supports its use as a positive control in SPR and BLI experiments characterizing anti-FGFR3 biologics or small-molecule inhibitors targeting the extracellular interface. Purity exceeding 95% by SDS-PAGE and endotoxin levels below 1.0 EU/μg align with standards expected in high-sensitivity binding platforms and cell-based receptor occupancy studies.