FGFR3

FGFR3, Fibroblast Growth Factor Receptor 3, alias FGFR3b, CD333, etc. FGFR3 is a transmembrane receptor tyrosine kinase, one of the members of the FGFR family, which is encoded by its own gene in human cells. Its mechanism of action is mainly through binding to fibroblast growth factor (FGF), which induces dimerization and autophosphorylation of FGFR3, and then activates the downstream signaling pathway.The activation of FGFR3 promotes cell proliferation, differentiation, migration, and survival, and has an important impact on biological processes such as tissue regeneration and tumor development.

FGFR3 has a wide range of biological significance, and it is involved in the regulation of a variety of cellular behaviors and physiological processes.Activation of the FGFR3 signaling pathway promotes cell cycle progression and inhibits apoptosis, thereby contributing to the maintenance of tumor cell survival. In addition, FGFR3 is closely related to malignant behaviors such as tumor invasion, metastasis and angiogenesis. In tumor therapy, FGFR3 has become an important molecular target, and inhibitors against FGFR3 are being developed for the treatment of certain types of cancers, such as bladder cancer, etc. Abnormalities in the function of FGFR3 have been associated with a wide range of diseases, including certain hereditary skeletal disorders and tumors, so in-depth study of the biological role of FGFR3 is important for understanding the pathogenesis of the relevant disorders and for the development of new therapeutic Therefore, an in-depth study of the biological role of FGFR3 is important for understanding the pathogenesis of related diseases and developing new therapeutic approaches.