Recombinant Human Frizzled-6 (FZD6), partial

1. miR-125b/miR-20b and Wnt signalling have roles in glioblastoma phenotypes in a pathway that involves FZD6 PMID: 27698350
2. Study reports a novel pathogenic variant of the FZD6 gene in autosomal recessive nonsyndromic congenital nail disorder in consanguineous Iranian family. PMID: 28545862
3. In this paper we report 3 further families with mutations in FZD6 causing Isolated recessive nail dysplasia. PMID: 27786367
4. monomeric rather than dimeric form is active signal initiating unit of the receptor complex; constitutive signaling to ERK1/2 can be affected by modulating the dimeric status PMID: 28790300
5. the FZD6-fibronectin actin axis identified in our study could be exploited for drug development in highly metastatic forms of breast cancer PMID: 27859262
6. we found that FZD6 expression was negatively regulated by miR199a5p PMID: 25772759
7. The rs3808553 of FZD6 is obviously associated with neural tube defects in Han population of northern China PMID: 24816679
8. It is associated with poor prognosis in glioblastoma patients. PMID: 23748645
9. This study confirms our speculation that down-regulation of FZD6 by beta-Carotene is causally related to the observed up-regulation of cancer related genes PMID: 24657404
10. DVL is a master regulator of FZD6/G-protein signaling PMID: 24500924
11. FZD6 should be screened for pachyonychia congenita as it is a candidate gene for hereditary nail dysplasias. PMID: 23374899
12. sequence analysis revealed a novel homozygous missense mutation (c.1266G>A; p.Gly422Asp) located in the transmembrane domain of the protein FZD6 in individuals of a consanguineous family exhibiting features of nail dysplasia PMID: 22861124
13. The present results emphasize the role of FZD6 mutation in Wnt pathways in nail development. PMID: 22211385
14. When transplanted into immunodeficient mice, neuroblastoma cells expressing the Fzd6 marker grow more aggressively than their Fzd6 negative counterparts. Fzd6 is a new surface marker of aggressive neuroblastoma cells with stem cell-like features. PMID: 22249030
15. This study demonstrates that rare nonsynonymous variants in FZD6 may contribute to NTDs in humans and enlarges the spectrum of mutations that link PCP pathway to Neural tube defects (NTDs). PMID: 22045688
16. The current study provides insight into the global changes in gene transcription mediated by chr-ECS and suggests that Fzd6 signaling could represent a novel target for development of novel antidepressants. PMID: 21937024
17. Mutations in this gene cause nail dysplasia. Review. PMID: 22078044
18. FZD6 mutations can result in severe defects in nail and claw formation through reduced or abolished membranous FZD(6) levels and several nonfunctional WNT-FZD pathways. PMID: 21665003
19. Frizzled 6 (HFz6) has a role as a negative regulator of the canonical Wnt. beta-catenin signaling cascade PMID: 14747478
20. These results suggested that activation of Wnt4/Fzd6 signaling through a "beta-catenin-independent" pathway played a role in proliferation and survival of the pituitary adenoma cells. PMID: 19034702
21. No significant association between C345A or A664C SNPs in the FZD6 gene and bone meineral density at skeletal sites measured or circulating levels of bone turnover markers were noted. PMID: 19543507

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HGNC: 4044

OMIM: 603409

KEGG: hsa:8323

STRING: 9606.ENSP00000351605

UniGene: Hs.591863