Recombinant Human Glycolipid transfer protein (GLTP)

1. GLTP was specifically labeled by either XLA or XLB GlcCer cross-linker during this process, together with a (the same) small subset of microsomal proteins. These cross-linkers will serve to probe physiologically relevant GlcCer-interacting cellular proteins PMID: 27412675
2. GLTP not only could be a significant player in cellular sphingolipid metabolism, but also could have a much broader role in the overall lipid metabolism. PMID: 24824606
3. GLTP mediates non-vesicular transport of ganglioside GM1 between native membranes PMID: 23555818
4. Comprehensive analysis of the dimerization interfaces discloses -helices 6 and 2 and the protein C-terminus (C-end) as three specific structural elements that are simultaneously involved in dimer formation and ligand binding by GLTP. PMID: 23519669
5. findings represent the first known phenotypic changes triggered by GLTP overexpression and regulated by direct interaction with a p120-catenin protein family member PMID: 21625605
6. This study represents the first characterization of any Gltp gene promoter and links human GLTP expression to sphingolipid homeostasis through ceramide PMID: 20974858
7. remarkable versatility for Trp, providing three distinct intramolecular functions in the novel amphitropic GLTP fold PMID: 20959104
8. First insights into human GLTP structural dynamics by fluorescence spectroscopy, including global conformational changes that accompany GLTP folding into an active conformational state. PMID: 15287756
9. crystal structures of apo-GLTP (1.65 A resolution) and lactosylceramide-bound (1.95 A) GLTP, in which the bound glycosphingolipid is sandwiched, after adaptive recognition, within a previously unknown two-layer all-alpha-helical topology PMID: 15329726
10. The rate-limiting step for glycolipid transfer protein (GLTP) action appears to be the surface processes leading to the GLTP-glycosphingolipid complex formation and release associated with a shuttle/carrier mode of action. PMID: 15504043
11. analysis of the liganding site in human glycolipid transfer protein PMID: 15901739
12. GLTP is not likely involved in the de novo synthesis of glycosphingolipids, but could rather have a role as a glycolipid sensor for the cellular levels of glucosylceramide. PMID: 17980653
13. Active transcription was found for 12q24.11 GLTP but 11p15.1 GLTP was transcriptionally silent. PMID: 18261224
14. transgenic expression in Arabidopsis thaliana of human GLTP partially suppressed the phenotype of the acd11 null mutant, resulting in delayed programmed cell death development and plant survival PMID: 18657186
15. Glycolipid acquisition by human glycolipid transfer protein dramatically alters intrinsic tryptophan fluorescence: insights into glycolipid binding affinity. PMID: 19270338
16. GLTP and VAP-A were shown to interact. PMID: 19665998
17. A single-copy 5-exon/4-intron GLTP gene at 12q24.11 was the highly conserved, transcript source of active GLTP in human and vertebrate cells. An intronless GLTP gene at 11p15.1 was transcriptionally silent, primate-specific, and yielded inactive protein. PMID: 18261224
18. The paper describes the complete primary amino acid sequence of glycolipid transfer protein (GLTP) from porcine brain. The sequence was determined by Edman degradation. PMID: 2190982
19. This paper shows that the rate at which glycolipid transfer protein catalyzes the intermembrane transfer of glycolipids is greatly diminished by increasing the charged lipid content of membranes. PMID: 10653652
20. This paper describes the first cloning of the cDNAs encoding the glycolipid transfer proteins of bovine and porcine brain. The cDNAs are highly homologous to the human cDNA (AF209704). PMID: 10671554

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HGNC: 24867

OMIM: 608949

KEGG: hsa:51228

STRING: 9606.ENSP00000315263

UniGene: Hs.381256