Recombinant Human Guanine nucleotide-binding protein G (olf) subunit alpha (GNAL)

1. GNAL mutation may represent one of the rare causative genetic factors of isolated laryngeal dystonia. PMID: 27093447
2. GNAL mutations are not a common cause of dystonia in the Brazilian population PMID: 26810727
3. We report a novel GNAL mutation in Italian family with adult-onset, dominantly-inherited dystonia PMID: 26725140
4. Mutations in the GNAL gene may not be a common cause of isolated dystonia in the Chinese population. PMID: 26365774
5. This study demonstrated that Mutations in GNAL may cause Dystonia. PMID: 25847575
6. identified two novel GNAL mutations: one heterozygous missense variant in GNAL exon 4, c.289A>G. PMID: 25382112
7. The findings of this study further support GNAL as causative gene in adult-onset isolated dystonia. PMID: 24408567
8. This study identified a novel likely disease-causing GNAL mutation in a Serbian patient with cervical dystonia and a classical DYT25 phenotype. PMID: 24729450
9. Primary dystonia in the Amish-Mennonites is genetically diverse and includes not only the THAP1 indel founder mutation but also different mutations in THAP1 and GNAL as well as the TOR1A GAG deletion. PMID: 24500857
10. GNAL variants seem to be a rare cause of primary torsion dystonia in our mainly sporadic German sample. PMID: 24151159
11. Our own data suggest that GNAL mutations do not represent a common cause of dystonia in the U.K. population. PMID: 24222099
12. The GNAL dystonia gene is central for striatal responses to dopamine (DA) and is a component of a molecular pathway already implicated in DOPA-responsive dystonia (DRD). PMID: 24144882
13. GNAL mutations potentially increase ethnic susceptibility to movement disorders induced by dopamine antagonists. PMID: 24535567
14. Mutations in GNAL gene can cause adult-onset primary dystonia in Chinese patients PMID: 23759320
15. Familial adult-onset primary dystonia can result from mutations in GNAL. PMID: 23449625
16. Mutations in GNAL cause primary torsion dystonia. PMID: 23222958
17. these findings provide important clues to understanding physiological functions of XLGalpha(olf). PMID: 22120635
18. investigation of whether polymorphisms in the alpha subunit of the Golf gene (A-->G in intron 3, and T-->G in intron 10) are associated with major depression; additionally tested for a parent-of-origin effect in separated gender groups PMID: 11901355
19. promotes cellular invasion, survival and neuroendocrine differentiation in colon, kidney and prostate epithelial cells PMID: 12037684
20. No support for the hypothesis that the olfactory G-protein gene is a major susceptibility factor for bipolar disorders. PMID: 12782961
21. identified a transcriptional variant of the GNAL gene in chromosome 18p11.2 in susceptibility to bipolar disorder and schizophrenia PMID: 16044173
22. Galpha(olf) variant XLGalpha(olf) interacts with the human adenosine A2A receptor PMID: 16818375
23. We hypothesized that the G(s)-like subunit Galpha(olf), expressed in D1-rich areas of the brain, contributes to the genetic susceptibility of ADHD. We examined the inheritance pattern of 12 GNAL polymorphisms in 258 nuclear families. PMID: 17166517
24. This study provides important clues toward understanding physiological functions of XLGalpha(olf). PMID: 19245791

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HGNC: 4388

OMIM: 139312

KEGG: hsa:2774

STRING: 9606.ENSP00000334051

UniGene: Hs.136295