Recombinant Human HLA class II histocompatibility antigen, DP beta 1 chain (HLA-DPB1), partial

1. Data suggest that HLA-DP molecules with beta-chains encoding Gly84 (DP(84Gly)) uses both class I and II antigen-processing pathways to present peptides derived from intracellular and extracellular sources. PMID: 28489076
2. HLA-DP polymorphisms (rs3077 and rs9277535) were associated with Systemic lupus erythematosus susceptibility in a Chinese population PMID: 28094303
3. High frequency expression of DPB1*0401 and *0601 are significantly associated with susceptibility to rheumatoid arthritis, it may be a risk factor for occurrence of rheumatoid arthritis. Low frequency expression of DPB1*0101, *0402 and *0501 may be negatively associated with rheumatoid arthritis, it may be a protective factor for occurrence of rheumatoid arthritis. PMID: 29425827
4. The rs3117242 of HLA-DPB1 could be considered a genetic risk factor for granulomatosis with polyangiitis in Chinese Han people. PMID: 26014903
5. HLA-DPB1*05:01 gene was associated with the geographical region of PV and the BTNL2 gene was significantly associated with family history and age of onset of PV. In conclusion, the HLA-DPB1*05:01 and BTNL2 genes might be responsible for the complicacy of clinical features. PMID: 28581127
6. In this single-center study, HLA-DPB1 matching influenced outcomes of patients undergoing ASCT for hematologic malignancy. PMID: 28632323
7. HLA-DPB1*15:01 allele was more frequent in the spontaneous seroconverted control group compared to Chronic hepatitis B Turkish patients. PMID: 29560661
8. Genotyping and expression analysis in HLA class II gene revealed that two single nucleotide polymorphisms of HLA-DPB1 (rs2071025 and rs3116996) were significantly correlated to RNA expression and progression of hepatitis C virus-related liver diseases. PMID: 28332201
9. Amino acid changes in the allergen-binding pocket of HLA-DPbeta1 are likely to influence pollinosis/sensitization to the allergenic peptide of JC pollen and determine the pollinosis risk for each individual exposed to JC pollen. PMID: 28460831
10. The results showed that rs9277535 HLA-DPB1 allele frequency is associated with chronic hepatitis B infection in the Turkish patients. PMID: 28119119
11. report contributes to emerging data showing clinical significance of the HLA-DP region genetic markers beyond structural matching of DPB1 alleles. PMID: 27595289
12. The HLA-DP rs9277535 variant genotypes were directly associated with hepatitis B virus persistence compared to healthy controls. PMID: 27291710
13. No statistically significant association was found between rs9277535 SNP and chronic hepatitis B. PMID: 28613373
14. Two new signals were observed at genome-wide significance (P < 5 x 10-8), namely, rs7216064 (17q24.3, BPTF), for overall lung adenocarcinoma risk, and rs3817963 (6p21.3, BTNL2) which is specific to cases with EGFR mutations. In further sub-analyses by EGFR status, rs9387478 (ROS1/DCBLD1) and rs2179920 (HLA-DPB1) showed stronger estimated associations in EGFR-positive compared to EGFR-negative cases PMID: 28025329
15. we show strong immunogenicity of HLA-DPB1 mismatch alleles in CD45RA-selected CD4 T cells of stem-cell donors and introduce a novel strategy to reliably generate HLA-DPB1-specific CD4 CTL that might be powerful cellular therapeutics in relapsed or refractory AML after HSCT. PMID: 27479183
16. There was no increased risk of rheumatoid arthritis in mothers of children with phenylalanine at position 9 of DPB1. PMID: 28391248
17. rs141530233 and rs1042169 at the HLA-DPB1 locus are associated with ANCA-associated vasculitis risk. PMID: 28029757
18. Seven nonconservative AA substitutions in peptide-binding positions had a significantly stronger impact on DeltaFD compared with 5 others (P = .0025), demonstrating qualitative differences in the relative impact of AA polymorphism in HLA-DPB1. PMID: 27162243
19. Study showed that HLA-DQ (rs7453920) was associated with prognosis of liver transplant recipients. The A allele of rs7453920 served as a protective factor in liver function recovery. HLA-DP (rs3077 and rs9277535) did not show any correlation with the hepatitis B virus infection and prognosis. PMID: 28640108
20. two dermatomyositis susceptibility loci at 7q34 and 10q24.2 PMID: 27153935
21. this study shows that HLA-DP gene polymorphisms are associated with ankylosing spondylitis in Southwest China PMID: 27394003
22. DRB1*13:02 (P = 0.0011, Pc = 0.0319, odds ratio [OR] 0.46, 95% confidence interval [CI] 0.29-0.73), DRB1*14:06 (P = 6.60X10-5, Pc = 0.0020, OR 0.05, 95%CI 0.01-0.41), DQB1*03:01 (P = 0.0009, Pc = 0.0150, OR 0.56, 95%CI 0.40-0.79), and DPB1*02:01 (P = 5.16X10-6, Pc = 8.77X10-5, OR 0.52, 95%CI 0.39-0.69) were protectively associated with Systemic Sclerosis in Japanese. PMID: 27116456
23. The HLA-DPB1*04:01:01G allele was significantly more frequent among women diagnosed with severe preeclampsia/eclampsia compared with controls. PMID: 27121092
24. the HLA-DP/DQ clusters contribute independently to HBV infection, and the 3'-UTR region of HLA-DPB1 represents an important functional region involved in HBV infection PMID: 26197724
25. Significant associations between chronic hepatitis B infection and five DPB1 alleles (two susceptibility alleles, DPB1(*) 05:01 and (*) 09:01, and three protective alleles, DPB1(*) 02:01, (*) 04:01, and (*) 04:02) were confirmed in Japanese individuals. PMID: 26449183
26. The observed positive association between integrated HIV-1 DNA load and frequency of CD8(+)DR/DP/DQ(+) cells indicates that a close correlation between HIV persistence and immune activation continues during consistently suppressive therapy. PMID: 26498496
27. Our results further confirm that genetic variants in the HLA-DP locus are strongly associated with reduced HBV infection and increased the likelihood of spontaneous viral clearance. PMID: 26462556
28. Thyroid autoimmunity is highly prevalent in type 1 diabetes mellitus patients and the risk is modulated by HLA-DRB1 and HLA-DPB1 loci. PMID: 26405068
29. DQB1*06 and DPB1*13 have roles in modulating vaccine-induced antibody responses to affect HIV-1 acquisition PMID: 26180102
30. rs9277535 in HLA-DPB1 is a significantly associated SNP associated with chronic hepatitis B virus infection and viral clearance. PMID: 24846544
31. Cellular misfolded proteins rescued from degradation by MHC class II molecules seem to be involved in autoimmune diseases as a target for autoantibodies. (review) PMID: 26915265
32. findings indicate the HLA-DPB1*13:01 and +550 A alleles are significantly associated with cervical squamous cell carcinoma (CSCC) risk in Taiwanese women; in addition, significant increase in CSCC risk was observed for HLA-DPB1*13:01-G and DPB1*02:01-A haplotypes PMID: 26031576
33. There was a significant linkage disequilibrium between these HLA-DP candidate SNPs and HLA-DPB1 protective alleles PMID: 25389088
34. This implies the potential of rs3128965 of HLA-DPB1 as a genetic marker for diagnosis and prediction of the AERD phenotype. PMID: 25536158
35. HLA-DPB1*04:01 may reduce the risk of tissue transglutaminase autoantibodies, an early marker of celiac disease, among DR3-DQ2 children, confirming that additional variants in the HLA region influence the risk for celiac disease autoimmunity. PMID: 26010309
36. Among recipients of HLA-DPB1-mismatched transplants from donors with the low-expression allele, recipients with the high-expression allele had a high risk of GVHD. PMID: 26267621
37. Results identified new susceptibility variants to narcolepsy in HLA-DPB1 and HLA-DQB1 loci in Japanese patients. PMID: 25256355
38. The affinities of peptides for Beryllium loaded HLA-DP2 were found to depend of their amino acid composition and the peptides carrying acidic group at positions 4 and 7 are among the strongest binders. PMID: 25369028
39. Polymorphisms in HLA-DPB1 are strongly associated with interindividual differences in neutralizing antibody levels to rubella vaccination. PMID: 25293367
40. This is the first report of the association between early Crohn's disease and the HLA DRB1*501 single nucleotide polymorphisms. PMID: 25664710
41. No increase in sarcoidosis was seen with either Glu69 or beryllium exposure. In Glu69 positive men with exposure >/=10 years, the trend towards increasing rate of COPD was reversed; a significant interaction of duration of exposure and Glu69 was detected. PMID: 25305207
42. Data indicate that thirty eight HLA-DPB1 alleles were found in the systemic scleroderma cohort. PMID: 24498086
43. HLA-DPB1 alleles influence the kinetics of anti-hepatitis B antibodies in hepatitis B booster recipients. PMID: 24285177
44. Data indicate that HLA-DP2 transgenic mice developed a beryllium-specific adaptive immune response composed of CD4+ T cells. PMID: 24912188
45. Data indicate five members of of DPbeta chains containing Lys-69 and GGPM 84-87, which assemble with DRalpha. PMID: 24214983
46. Our results demonstrated that the rs3077 and rs9277535 HLA-DP polymorphisms reduced hepatitis B virus infection and increased the likelihood of spontaneous viral clearance in some Asian populations. PMID: 23601003
47. Studied three HLA-DP and IL28B SNPs of CHB patients with and without spontaneous HBsAg seroclearance. Haplotype analysis of HLA-DP polymorphisms showed association with HBsAg seroclearance. PMID: 23449268
48. HLA-DRB1*04:01 and HLA-DPB1*04:01 alleles were detected at higher frequencies in influenza-seroprotected compared with non-seroprotected individuals. PMID: 23951151
49. The conditional logistic regression tests showed that DPB1*04:01 is independently associated with non-obstructive azoospermia(NOA), confirming the involvement of the HLA region in the etiology of NOA in Japanese patients. PMID: 23934009
50. We identified the SEMA6A and HLA-DP loci as significant contributors to risk for granulomatosis with polyangiitis, with the HLA-DPB1*04 allele almost completely accounting for the MHC association PMID: 23740775

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HGNC: 4940

OMIM: 142858

KEGG: hsa:3115

STRING: 9606.ENSP00000408146

UniGene: Hs.485130