Recombinant Human HORMA domain-containing protein 2 (HORMAD2)

Code CSB-YP836683HU
MSDS
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Source Yeast
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Code CSB-EP836683HU
MSDS
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Source E.coli
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Code CSB-EP836683HU-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP836683HU
MSDS
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Source Baculovirus
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Code CSB-MP836683HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
HORMAD2
Uniprot No.
Alternative Names
4930529M09Rik; CT46.2; HORM2_HUMAN; HORMA domain containing 2; HORMA domain-containing protein 2; Hormad2; MGC26710; RP23-329P17.4
Species
Homo sapiens (Human)
Expression Region
1-307
Target Protein Sequence
MATAQLSHCI TIHKASKETV FPSQITNEHE SLKMVKKLFA TSISCITYLR GLFPESSYGE RHLDDLSLKI LREDKKCPGS LHIIRWIQGC FDALEKRYLR MAVLTLYTDP MGSEKVTEMY QFKFKYTKEG ATMDFDSHSS STSFESGTNN EDIKKASVLL IRKLYILMQD LEPLPNNVVL TMKLHYYNAV TPHDYQPLGF KEGVNSHFLL FDKEPINVQV GFVSTGFHSM KVKVMTEATK VIDLENNLFR ENSTTEIAHQ GLDCDEEEEC NDHIQRMNFV CSQQSSECSR KKRKVSEPVK VFIPNRK
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation.
Gene References into Functions
  1. The variant rs2412971, intronic in HORMAD2 at chromosome 22q12.2, was robustly associated with tonsillectomy. PMID: 27941131
  2. These findings indicate that polymorphisms at the CT gene HORMAD2 might be involved in the prognosis of advanced non-small-cell lung cancer in Han Chinese. PMID: 24797335
  3. HORMAD2 is predominantly expressed in human testis and weakly expressed in liver. HORMAD2 is ectopically expressed in nearly 10% of lung cancer samples from Chinese Han individuals. PMID: 22893617
Subcellular Location
Nucleus. Chromosome.
Tissue Specificity
Highly expressed in testis (at protein level). Expressed in lung adenocarcinoma and squamous cell carcinoma (at protein level). Expressed at lower levels in the liver, brain and kidney.
Database Links

HGNC: 28383

KEGG: hsa:150280

STRING: 9606.ENSP00000336984

UniGene: Hs.120391

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