Recombinant Human Histidine decarboxylase(HDC)

Code CSB-YP010246HU
Size US$1916
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

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Product Details

Purity Greater than 90% as determined by SDS-PAGE.
Target Names HDC
Uniprot No. P19113
Research Area others
Alternative Names DCHS_HUMAN; EC 4.1.1.22; HDC; Histidine decarboxylase
Species Homo sapiens (Human)
Source Yeast
Expression Region 1-662aa
Target Protein Sequence MMEPEEYRERGREMVDYICQYLSTVRERRVTPDVQPGYLRAQLPESAPEDPDSWDSIFGDIERIIMPGVVHWQSPHMHAYYPALTSWPSLLGDMLADAINCLGFTWASSPACTELEMNVMDWLAKMLGLPEHFLHHHPSSQGGGVLQSTVSESTLIALLAARKNKILEMKTSEPDADESCLNARLVAYASDQAHSSVEKAGLISLVKMKFLPVDDNFSLRGEALQKAIEEDKQRGLVPVFVCATLGTTGVCAFDCLSELGPICAREGLWLHIDAAYAGTAFLCPEFRGFLKGIEYADSFTFNPSKWMMVHFDCTGFWVKDKYKLQQTFSVNPIYLRHANSGVATDFMHWQIPLSRRFRSVKLWFVIRSFGVKNLQAHVRHGTEMAKYFESLVRNDPSFEIPAKRHLGLVVFRLKGPNCLTENVLKEIAKAGRLFLIPATIQDKLIIRFTVTSQFTTRDDILRDWNLIRDAATLILSQHCTSQPSPRVGNLISQIRGARAWACGTSLQSVSGAGDDPVQARKIIKQPQRVGAGPMKRENGLHLETLLDPVDDCFSEEAPDATKHKLSSFLFSYLSVQTKKKTVRSLSCNSVPVSAQKPLPTEASVKNGGSSRVRIFSRFPEDMMMLKKSAFKKLIKFYSVPSFPECSSQCGLQLPCCPLQAMV
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Mol. Weight 76.2kDa
Protein Length Full Length
Tag Info N-terminal 6xHis-tagged
Form Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

Target Data

Function Catalyzes the biosynthesis of histamine from histidine.
Gene References into Functions
  1. Human histidine decarboxylase (HDC) and dopa decarboxilase (DDC) are highly homologous enzymes responsible for the synthesis of biogenic amines (BA) like histamine, and serotonin and dopamine, respectively. This review summarizes the analogies and differences in their origin as well as their common pathophysiological scenarios. [review] PMID: 27769832
  2. a Possible Role for the Histidine Decarboxylase Gene in Tourette Syndrome in the Chinese Han Population PMID: 27529419
  3. Human enterochromaffin-like cells appear to partially co-express VMAT-2 and HDC. Co-expression of VMAT-2 and HDC might be required for increased histamine production in patients with gastric neuroendocrine tumors. PMID: 26715806
  4. The findings indicate that polymorphisms of HDC gene were significantly associated with breast cancer in Chinese Han population and may be novel diagnostic or therapeutic targets for breast cancer. PMID: 24835231
  5. HDC rs17740607 polymorphism is at least a partial loss-of-function variant and acts as a protective factor against chronic heart failure PMID: 25846768
  6. Investigated variation across the HDC (histidine decarboxylase) gene for association with Tourette Syndrome. PMID: 23825391
  7. HDC production in the stomach is associated with bile acid exposure and its related transcriptional regulation network of FXR, SHP, and CDX1. PMID: 24415870
  8. Data indicate that histidine decarboxylase (HDC) is expressed by neutrophils. PMID: 23572231
  9. Structural study reveals that Ser-354 determines substrate specificity on human histidine decarboxylase. PMID: 22767596
  10. crystal of histidine decarboxylase belonged to space group C2, with unit-cell parameters a = 215.16, b = 112.72, c = 171.39 A, beta = 110.3 degrees PMID: 22684068
  11. It was shown that for serum and urine, HDC levels achieved sensitivities and specificities compatible to or even greater than those of established biomarkers for the diagnosis of intestinal mucosal injury in patients with acute intestinal obstruction. PMID: 21915437
  12. The novel concept that an autocrine loop, consisting of enhanced histamine synthesis by histidine decarboxylase, sustains cholangiocarcinoma growth is proposed. PMID: 21873469
  13. Variants in the HDC gene may play little or no role in Tourette Syndrome susceptibility in Chinese Han population. PMID: 22095709
  14. Studies provide lead compounds for inhibitors of ornithine decarboxylase and human histidine decarboxylase. PMID: 21454364
  15. The histidine decarboxylase allele Glu644 in homozygosity increases the risk of developing rhinitis in the studied population PMID: 20608921
  16. identification of a rare functional mutation in the HDC gene encoding L-histidine decarboxylase, the rate-limiting enzyme in histamine biosynthesis which points to its role in Tourette's syndrome and tics PMID: 20445167
  17. the elevation of HDC expression during human monocytic differentiation PMID: 11556524
  18. HDC expression is regulated by gastrin through a complex cis-acting element, which binds at least three distinct nuclear factors PMID: 12372397
  19. Histidine decarboxylase promoter activity can be repressed by kruppel-like factor 4 PMID: 14670968
  20. histidine decarboxylase mRNA is found in human vascular smooth muscle and endothelial cells PMID: 15167966
  21. HDC and histamine content were significantly higher in the tumor specimens PMID: 15928846
  22. Chronic urticaria expresses high levels of HDC as compared to normal foreskin, breast skin and cultured human keratinocytes. PMID: 16297195
  23. HDC expression and histamine production are increased in the superficial kidney cortex zone during pregnancy PMID: 16760908
  24. Defective levels found in normal placenta compared with pre-eclampsia labor. PMID: 16822545
  25. Synthesis of histamine was found to be restricted to the basophil compartment of the CML clone and to depend on signaling through the PI3-kinase pathway. CML cells also expressed histamine receptors PMID: 16849647
  26. HDC SNP's are significantly associated with age at natural menopause in Caucasian women. PMID: 16919600
  27. Histamine decarboxylase expressed in endothelial cells of microvessels might play a role in regulating angiogenesis in esophageal squamous cell carcinomas. PMID: 19133005
  28. HFR was regulated by HIF-1 activation. Depletion of HIF-1alpha prevents hypoxic induction of HDC in BMMCs. Hypoxia induces HDC expression by transcriptional mechanisms dependent upon HIF-1. PMID: 19266161
  29. the apparent occurrence of an unusual TG 3' splice site in intron 4 is discussed PMID: 17672918

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Protein Families Group II decarboxylase family
Database Links

HGNC: 4855

OMIM: 142704

KEGG: hsa:3067

STRING: 9606.ENSP00000267845

UniGene: Hs.1481

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