Recombinant Human Homeobox protein EMX2 (EMX2)

Code CSB-YP007657HU
MSDS
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Source Yeast
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Code CSB-EP007657HU
MSDS
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Source E.coli
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Code CSB-EP007657HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP007657HU
MSDS
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Source Baculovirus
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Code CSB-MP007657HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
EMX2
Uniprot No.
Alternative Names
Empty spiracles homeobox 2; Empty spiracles homolog 2 (Drosophila); Empty spiracles homolog 2; Empty spiracles like protein 2; Empty spiracles-like protein 2; EMX 2; EMX2; EMX2_HUMAN; Homeobox protein EMX 2; Homeobox protein EMX2
Species
Homo sapiens (Human)
Expression Region
1-252
Target Protein Sequence
MFQPAPKRCF TIESLVAKDS PLPASRSEDP IRPAALSYAN SSPINPFLNG FHSAAAAAAG RGVYSNPDLV FAEAVSHPPN PAVPVHPVPP PHALAAHPLP SSHSPHPLFA SQQRDPSTFY PWLIHRYRYL GHRFQGNDTS PESFLLHNAL ARKPKRIRTA FSPSQLLRLE HAFEKNHYVV GAERKQLAHS LSLTETQVKV WFQNRRTKFK RQKLEEEGSD SQQKKKGTHH INRWRIATKQ ASPEEIDVTS DD
Protein Length
Full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system.
Gene References into Functions
  1. EMX2 is frequently down-regulated in human colorectal cancer, and down-regulation of EMX2 is a prognostic marker for disease-free and overall survival. PMID: 28830374
  2. Emx2 is a novel promising tool for therapy of glioblastoma and prevention of its recurrences. PMID: 27191499
  3. EMX2 inhibits proliferation and tumorigenesis through inactivation of the Wnt/beta-catenin pathway in CRC cells. PMID: 27712600
  4. EMX2 expression was down-regulated in lung SCC tissue compared to matched adjacent normal tissue. EMX2 expression was associated with improved overall survival. Knockdown promoted chemo-resistance and cell migration. PMID: 26132438
  5. Although it is uncommon (0.19%), EMX2 is the first gene identified that if perturbed may cause isolated incomplete mullerian fusion. PMID: 25577462
  6. Deletions of EMX2 have been associated with a wide range of DSD. PMID: 24975717
  7. EMX2 expression is downregulated in advanced cases of malignant pleural mesothelioma and may serve as an important prognostic and predictive molecular biomarker of progression-free survival. PMID: 25023662
  8. downregulation of empty spiracles homeobox 2 (EMX2) was associated with tumor progression and may be a critical factor in the carcinogenesis and progression of endometrial cancer PMID: 23370654
  9. EMX2 expression led to inhibition of cell proliferation and Wnt signaling pathway both in vitro and in a gastric cancer xenograft model in vivo. PMID: 23029345
  10. Study analyzed mutations of EMX2 gene in 45 prostate carcinomas, 51 non-small cell lung cancers, 43 gastric carcinomas, 44 colorectal carcinomas, and 43 breast carcinomas by polymerase chain reaction and single-strand conformation polymorphism assay. PMID: 21917011
  11. Downregulation of EMX2 is associated with clinical outcomes in lung adenocarcinoma. PMID: 21726823
  12. Data show that human teneurin-1 is directly regulated by EMX2 at a conserved promoter region upstream of the transcription start site, and identify and characterize the EMX2 dependent promoter element of human teneurin-1. PMID: 21651764
  13. promoter. Restoration of EMX2 expression in lung cancer cells lacking endogenous EMX2 expression suppressed cell proliferation and invasive phenotypes PMID: 20697358
  14. EMX2 gene has been reported in schezencephaly (cleft brain) including epilepsy in some patients. PMID: 12185771
  15. In these studies we identify and characterize the regulation of EMX2 by HOXA10. PMID: 12482956
  16. Endometrial EMX2 expression is aberrant in women with endometriosis and is mediated by altered HOXA10 expression. PMID: 15126568
  17. EMX2 levels in cortical progenitors of EMX2 transgenic mice disproportionately specify sizes and positions of primary cortical areas. PMID: 15294144
  18. It is unlikely that the EMX2 or PTEN gene variants investigated contribute to risk for initiation and/or development of endometriosis. PMID: 17563403
  19. provide results of EMX2 sequencing in 39 new schizencephaly patients, detecting no pathogenic mutations PMID: 18409201
  20. These data support recent reports that EMX2 but not PAX6 is more directly involved in arealization, highlighting that analysis of human development allows better spatio-temporal resolution than studies in rodents. PMID: 18973570

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Involvement in disease
Schizencephaly (SCHZC)
Subcellular Location
Nucleus.
Protein Families
EMX homeobox family
Tissue Specificity
Cerebral cortex.
Database Links

HGNC: 3341

OMIM: 269160

KEGG: hsa:2018

STRING: 9606.ENSP00000358202

UniGene: Hs.202095

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