Recombinant Human Homeobox protein Hox-C8 (HOXC8)

Code CSB-YP010678HU
MSDS
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Source Yeast
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Code CSB-EP010678HU
MSDS
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Source E.coli
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Code CSB-EP010678HU-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP010678HU
MSDS
Size Pls inquire
Source Baculovirus
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Code CSB-MP010678HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
HOXC8
Uniprot No.
Alternative Names
Homeo box 3A; Homeo box 8; Homeobox 3A; Homeobox C8; Homeobox protein Hox C8; Homeobox protein Hox-3A; Homeobox protein Hox-C8; Homeobox protein HoxC8; Homeobox protein R4; Homolog of mouse Hox 3.1; HOX 3; Hox 3.1 mouse homolog of; HOX 3A; HOX C8; Hox-3.1; Hox-3A; HOX3; HOX3A; HOXC 8; Hoxc-8; HOXC8; HXC8_HUMAN; M31
Species
Homo sapiens (Human)
Expression Region
1-242
Target Protein Sequence
MSSYFVNPLF SKYKAGESLE PAYYDCRFPQ SVGRSHALVY GPGGSAPGFQ HASHHVQDFF HHGTSGISNS GYQQNPCSLS CHGDASKFYG YEALPRQSLY GAQQEASVVQ YPDCKSSANT NSSEGQGHLN QNSSPSLMFP WMRPHAPGRR SGRQTYSRYQ TLELEKEFLF NPYLTRKRRI EVSHALGLTE RQVKIWFQNR RMKWKKENNK DKLPGARDEE KVEEEGNEEE EKEEEEKEEN KD
Protein Length
Full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Gene References into Functions
  1. Results show that HOXC8 is consistently downregulated in stem/progenitor cells of all breast molecular subtypes, thus representing a putative tumor suppressor candidate. Also, downregulated expression of HOXC8 is associated with DNA methylation at the gene promoter and expression of miR196 family members. Taken together, study establishes HOXC8 as a suppressor of stemness and transformation in the mammary gland lineage. PMID: 28202042
  2. Owing to the overexpression of Homeobox C8 (HOXC8), findings implied that HOXC8 is involved in the progression of epithelial ovarian cancer (EOC) and could be a potential therapeutical approach of EOC. PMID: 26763553
  3. High expression of HOXC8 is associated with laryngeal squamous cell carcinoma. PMID: 27658780
  4. HOXC8 knockdown led to inhibition of tumor cell proliferation and migration in vitro by inhibiting MMP-9 expression and tumor growth in vivo. The results strongly suggest that HOXC8 is involved in the tumorigenesis of osteosarcoma and might serve as a novel predictor for patients' outcome. PMID: 27651160
  5. embigin is regulated by HOXC8 and its loss plays an important role in the progression of breast tumors PMID: 26090721
  6. Ectopic expression of HoxC8 inhibits nasopharyngeal carcinoma cell growth in vitro and in vivo, modulates glycolysis and regulates the expression of tricarboxylic acid (TCA) cycle-related genes. PMID: 25745994
  7. Upregulated HOXC8 expression was associated with oxaliplatin resistance in hepatocellular carcinoma. PMID: 26123838
  8. miR-196a was over-expressed in cervical cancer cells, while an absence of HOXC8 expression was observed. PMID: 24817935
  9. HOXC8 promotes breast tumorigenesis by transcriptionally facilitating cadherin-11 expression. PMID: 24810778
  10. HOXC8 can be used as a prognostic marker in esophageal squamous cell carcinoma PMID: 24525058
  11. HOXC8 expression is inversely related to pancreatic ductal adenocarcinoma progression and metastasis. PMID: 21712827
  12. a complex role for HOXC8 in prostate cancer, promoting invasiveness while inhibiting AR-mediated gene induction at androgen response element-regulated genes associated with differentiated function of the prostate PMID: 21047772
  13. Ratio of microRNA to HOXC8 mRNA may be an indicator of the metastatic capability of breast tumors. PMID: 20736365
  14. overexpression associated with loss of tumor differentiation in human prostate cancer; may play role in acquisition of invasive/metastatic phenotype PMID: 11813208
  15. Androgen-independent cell line DU145 cells lack PLZF gene expression, resulting in the upregulation of Pbx1 and HoxC8 expression. The Pbx1-HoxC8 heterocomplex may lead to androgen-independent growth in prostate cancer. PMID: 16637071

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Subcellular Location
Nucleus.
Protein Families
Antp homeobox family
Database Links

HGNC: 5129

OMIM: 142970

KEGG: hsa:3224

STRING: 9606.ENSP00000040584

UniGene: Hs.664500

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