Recombinant Human Homeobox protein engrailed-2 (EN2)

1. The EN2 transcription factor is a novel ovarian cancer biomarker. It demonstrates prognostic value, correlating with worse Overall Survival and Progression-free Survival. PMID: 30285763
2. we confirmed that engrailed-2 is the target of hsa-miR-27b in human cytomegalovirus-infected glioma cells PMID: 28343438
3. The critical role of miR212 in inhibiting prostate tumor growth was verified in xenograft models of prostate cancer. These findings highlighted the role of miR212 in PCa progression. More importantly, we speculate that EN-2 is a direct target gene of miR212. PMID: 28713997
4. We identified a novel heterozygous missense variant (c.425C>G, p.Pro142Arg) in the Engrailed 2 (EN2) gene in two patients. The G variant has never been reported in public databases and was absent in 100 Thai patients with ASD and 435 Thai controls. A case-control study showed that the G allele of c.425C>G was significantly associated with ASD PMID: 27755371
5. EN2 is negatively regulated by miR-605, and down-regulation of miR-605 promotes the proliferation and invasion of prostate cancer (PCa) cells by up-regulating EN2, which leads to PCa development and progression PMID: 28943214
6. Our data suggest that the functional interaction of miR-33a and EN-2 is involved in tumorigenesis of prostate cancer PMID: 27921232
7. the results demonstrated that EN2 might play an anti-oncogenic role in oncogenesis and development of CCRCC, thereby maintaining the normal growth of human renal tubular epithelial cells. PMID: 26948025
8. EN2 may be a candidate oncogene in bladder cancer by activating the PI3K/Akt pathway and inhibiting PTEN. PMID: 25812440
9. Engrailed-2 (EN-2) is a developmentally regulated homeobox gene that is essential for Purkinje cell maturation and normal cerebellar development and patterning. PMID: 25290267
10. The mean EN2 levels in prostate cancer patients were 3.76-fold higher than those in non-prostate patients after prostate massage. PMID: 25003607
11. The exact role of EN2 expression in renal carcinoma carcinogenesis requires further investigation. PMID: 24532139
12. En2 identified as a new regulator of T-cell differentiation whose disruption induces a malignant T-cell fate in chronic myelogenous leukemia progression. PMID: 24675889
13. Two patients with underdeveloped arcuate fasciculus had novel, nonsynonymous variants in MID1 and EN2 genes regulating axon guidance pathway. PMID: 24321989
14. EN2 levels are increased in affected individuals with an A-C/G-T genotype, supporting EN2 as an autism spectrum disorder susceptibility gene. PMID: 24520327
15. urinary EN2 has the potential to be a more sensitive and specific protein biomarker for non-muscle-invasive bladder cancer than currently available tests. PMID: 23434148
16. Urinary EN2 may be useful as a non-invasive early biomarker for prostate cancer detection in genetically high-risk individuals PMID: 23792811
17. Normal EN-2 downregulation may not occur in some individuals with autism, such that the postnatal persistence of EN-2 overexpression may contribute to autism cerebellar abnormalities. PMID: 23423141
18. The WNT2 gene and EN2 gene may act in concert to influence the language development in autism. PMID: 22522212
19. findings show EN2 was expressed and secreted by prostate cancer (PC) cell lines and PC tissue but not by normal prostate tissue or stroma; presence of EN2 in urine was highly predictive of PC PMID: 21364037
20. This study demonistrated that in Han chinese the association between the EN2 genetic polymorphism and autism. PMID: 20523082
21. Positive genetic correlation of EN2 with autism in the Indian population. PMID: 20050924
22. In human, failure to form a mesencephalon and metencephalon, with cerebellar hypoplasia, results drom a mutation or deletion in EN2(Engrailed-2) gene. PMID: 11815869
23. EN2 exon 1 variant transmission disequilibrium test shows no association with autistic disorder nor association between language and stereotypic behaviour quantitative traits. PMID: 12525552
24. An association between a cerebellar patterning gene and autism spectrum disorder suggests a role for EN2 as a susceptibility locus and supports a neurodevelopmental defect hypothesis in the etiology of autism. PMID: 15024396
25. RNA interference studies suggest that EN2 expression is required for the maintenance of the transformed phenotype of a human breast tumor cell line PMID: 16007149
26. Loss and gain of function experiments firmly establish that En1/2 is a true survival factor for dopaminergic neurons in vivo. PMID: 17267560
27. Heterogeneous association between engrailed-2 and autism in the CPEA network PMID: 17948868
28. a preferential transmission of the rs3824068 A-allele to AUTISM affected offspring PMID: 17948901
29. Engrailed 2 gene is associated with autistic disorder in Chinese children. PMID: 18424904
30. The majority of regulated genes were down-regulated in engrailed-2 cerebella from transgenic mice, consistent with the known repressive function of Engrailed-2. PMID: 18562208
31. variations of the engrailed-2 gene are implicated in the development of young-onset Parkinson's disease PMID: 19270442
32. The data of this study indicated that the A-C haplotype is functional and, together with the association and LD mapping results, supports EN2 as a likely autism susceptibility gene and the A-C haplotype as a possible risk allele. PMID: 19615670

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HGNC: 3343

OMIM: 131310

KEGG: hsa:2020

STRING: 9606.ENSP00000297375

UniGene: Hs.134989