Recombinant Human Homer protein homolog 1 (HOMER1)

Code CSB-YP773061HU
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Source Yeast
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Code CSB-EP773061HU
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Source E.coli
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Code CSB-EP773061HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP773061HU
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Source Baculovirus
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Code CSB-MP773061HU
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
HOMER1
Uniprot No.
Alternative Names
HOME1_HUMAN; Homer ; HOMER 1A; HOMER 1B ; HOMER 1C; Homer homolog 1 (Drosophila); homer homolog 1; Homer protein homolog 1; homer scaffolding protein 1; Homer; Drosophila; homolog of; 1; Homer; neuronal immediate early gene; 1 ; Homer-1; Homer1; HOMER1A; HOMER1B; HOMER1C; SYN47 ; Ves 1
Species
Homo sapiens (Human)
Expression Region
1-354
Target Protein Sequence
MGEQPIFSTR AHVFQIDPNT KKNWVPTSKH AVTVSYFYDS TRNVYRIISL DGSKAIINST ITPNMTFTKT SQKFGQWADS RANTVYGLGF SSEHHLSKFA EKFQEFKEAA RLAKEKSQEK MELTSTPSQE SAGGDLQSPL TPESINGTDD ERTPDVTQNS EPRAEPTQNA LPFSHSSAIS KHWEAELATL KGNNAKLTAA LLESTANVKQ WKQQLAAYQE EAERLHKRVT ELECVSSQAN AVHTHKTELN QTIQELEETL KLKEEEIERL KQEIDNAREL QEQRDSLTQK LQEVEIRNKD LEGQLSDLEQ RLEKSQNEQE AFRNNLKTLL EILDGKIFEL TELRDNLAKL LECS
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA.
Gene References into Functions
  1. Monomeric Homer 1a proteins increase activity of Imin channels, but did not modulate their electrophysiological properties. Recombinant Homer 1c protein did not block the induced calcium currents. PMID: 29923011
  2. Study found the common variant rs7713917 in the HOMER1 gene to be significantly associated with suicide attempt in Chinese patient. PMID: 30219717
  3. Homer 1 rs7713917 gene variant associated with brain structure and function, severity of depression, and antidepressant response in patients affected by a major depressive episode in course of bipolar disorder. PMID: 29079138
  4. This study demonstrate that altered Homer1a levels in specific brain regions and cell types of patients suffering from schizophrenia, bipolar disorder and major depression. PMID: 28815330
  5. Study shows that Homer1b/c is constitutively expressed in astrocytes, where it clusters with mGlu5 and endoplasmic reticulum tubules to form sub-plasmalemmal microdomains; propose that Homer1a may represent one of the cellular mechanisms by which inflammatory astrocytic reactions are beneficial for limiting brain injury PMID: 27075036
  6. Resequencing three candidate genes (HOMER1, SLC6A4, and TEF) discovers seven potentially deleterious variants susceptibility to major depressive disorder and suicide attempts in Chinese. PMID: 27964944
  7. The present study was undertaken to determine the expression and functional significance of Homer1b/c in multiple myeloma PMID: 26718835
  8. The main focus of the present review is to offer an overview of the current knowledge about the potential role of Homer1a in depression and the signaling pathways responsible for Homer1a regulation. [review] PMID: 26641965
  9. The mRNA levels of Homer1, IL-1beta, and TNF-alpha in coronary artery disease patients were significantly higher than those in the control group, but not Homer2 and Homer3. PMID: 25551602
  10. these findings provide evidence for a new role of Homer1 supporting the regulation of Cav1.2 channels by STIM1. PMID: 25712868
  11. Homer1 promotes lymphatic invasion and associates with lymph node metastasis and poor prognosis of intrahepatic cholangiocarcinoma. PMID: 24815486
  12. data suggest that HOMER1 rs4704559 G allele has a protective role for the development of levodopa adverse effects PMID: 24126708
  13. Polymorphisms of DRD1, DLG4 and HOMER1 are associated with opiate abuse. PMID: 23044706
  14. Overexpression of HOMER1A reduces neuropathic pain hypersensitivity. PMID: 23685007
  15. The uncoupling of synaptic protein homer 1c from target proteins activates store-operated calcium entry in a neurotransmitter-like manner in human neuroblastoma cells. PMID: 23821062
  16. This review discusses the association of Homer 1 variants with the etiology of many neurological diseases, such as pain, mental retardation syndromes, Alzheimer's disease, schizophrenia, addiction and traumatic brain injury. PMID: 22749857
  17. HOMER1 encodes a postsynaptic density-localized scaffolding protein that interacts with Shank3 to regulate mGluR activity, and is a novel autism-risk gene. PMID: 22558107
  18. This study reported significant associations between different polymorphisms of the HOMER 1 gene and psychopathology of schizophrenic patients at baseline and between HOMER 1 polymorphisms and therapy response after treatment with atypical antipsychotics. PMID: 20598711
  19. Homer dissociation from its targets evoked by the PPKKFR peptide led to Imin calcium channel activation but not to Imax calcium channel activation in A431 cells. PMID: 20926133
  20. HOMER1 plays a role in the etiology of major depression and genetic variation affects depression via the dysregulation of cognitive and motivational processes. PMID: 20673876
  21. Homer1a transgene expression is transiently upregulated during increases in network activity and evokes agonist-independent signaling of group I metabotropic glutamate receptors that scales down expression of synaptic AMPA receptors. PMID: 21172614
  22. HOMER1 was screened for an association with schizophrenia. PMID: 12815733
  23. Polymorphism in the Homer1 gene is a potential risk factor for the development of cocaine dependence in an African American population. PMID: 16314758
  24. Data indicate that Homer1 plays a critical role in determining the apoptotic susceptibility to TRAIL. PMID: 19376111
  25. study implicates the effects of allele A of the rs4704559 marker in susceptibility to psychotic symptoms in Parkinson disease PMID: 19648775

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Subcellular Location
Cytoplasm. Cell junction, synapse, postsynaptic density. Cell junction, synapse. Cell projection, dendritic spine.
Protein Families
Homer family
Database Links

HGNC: 17512

OMIM: 604798

KEGG: hsa:9456

STRING: 9606.ENSP00000334382

UniGene: Hs.591761

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