Recombinant Human Interleukin-1 receptor-associated kinase 3 (IRAK3)

1. Clinical trial with house dust mite allergen challenge of asthmatic patients reveal that IRAK-M is a PIN1 target critical for IL-33 signaling in allergic asthma. NMR analysis and docking simulations suggest that PIN1 might regulate IRAK-M conformation and function in IL-33 signaling. PMID: 29686383
2. Rs11541076 in IRAK3, a negative regulator of TLR signalling, as a predictor of anti-TNF treatment response. PMID: 27698401
3. MERS-CoV S protein binds to DPP4 to suppress macrophage activation via induction of IRAK-M, PPARgamma and the immunosuppressive cytokine IL-10. PMID: 28118607
4. Data indicate a strong positive correlation between interleukin-1 receptor-associated kinase 3 (IRAK-M) and pSTAT3 protein in colorectal cancer (CRC). PMID: 27150039
5. IRAK-M functions to modulate inflammatory signaling pathways and is critical in maintaining immune system homeostasis in the gut. However, increased IRAK-M is associated with increased disease pathogenesis and increased cancer severity in human patients. PMID: 27939424
6. Alpha-Melanocyte-Stimulating Hormone Suppresses TLR2-Mediated Functional Responses through IRAK-M in Normal Human Keratinocytes PMID: 26309029
7. IRAK3 methylation was associated with tumor stage and poor prognosis of hepatocellular carcinoma patients. PMID: 25852282
8. The structure function of the death domain of human IRAK-M PMID: 25481771
9. HIF1alpha is a regulator of monocyte functional re-programming in sepsis via regulating IRAKM expression. PMID: 25746953
10. IRAK-M expression is upregulated in peripheral blood cells from idiopathic pulmonary fibrosis patients PMID: 25595781
11. our study demonstrates that patients carrying IRAK-M+22148 G haplotype are more susceptible to sepsis than patients carrying IRAK-M+22148 A haplotype, suggesting that IRAK-M+22148 G haplotype might be a risk factor for sepsis. PMID: 23588345
12. These data indicate the enhancing effect of IRAK-M on epithelial human rhinovirus-16 infection, which is partly through the autophagic pathway. PMID: 24074582
13. IRAK-M mediates TLR7-induced MEKK3-dependent second wave NFjB activation to produce inhibitory molecules PMID: 23376919
14. the tested variations of IRAK-M and SIGIRR genes do not confer a relevant role in the susceptibility to systemic lupus erythematosus in European-descent populations PMID: 22634523
15. these data identify an important signaling regulator in human macrophages that is used by surfactant to control the long-term alveolar inflammatory response, i.e., enhanced IRAK-M activity. PMID: 22886503
16. these data indicate that epithelial IRAK-M overexpression in T(H)2 cytokine-exposed airways inhibits TLR2 signaling, providing a novel mechanism for the increased susceptibility of infections in asthmatic patients. PMID: 22154382
17. Data suggest further evaluation of IRAK3 as a diagnostic and prognostic marker, and as a target for intervention. PMID: 22272346
18. The results confirm the importance of the IRAK3 in asthma pathogenesis in the European populations PMID: 22070913
19. The upregulation of IRAK-M in macrophages is involved in the local immunosuppression around implants, and may contribute to septic and aseptic implant loosening. PMID: 21987497
20. Common SNPs in the IRAK3 gene may be determinants of sepsis-induced acute lung injury. PMID: 21297081
21. Data demonstrates that TGF-beta-dependent induction of IRAK-M expression is an important, clinically relevant mechanism by which tumors may circumvent anti-tumor responses of macrophages. PMID: 21278795
22. Intact IRAK-M is strongly expressed in resting human alveolar macrophages but is cleaved in patients with pneumonia via neutrophil-mediated induction of caspase-6 (CASP-6) activity. PMID: 21098228
23. Identification and characterization of murine IRAK-M PMID: 12054681
24. Thus, our data indicate that IRAK-M could play a pivotal role in the process of endotoxin tolerance in human monocytes and provide evidence that PI3K is involved in regulating its expression. PMID: 14592437
25. IRAK-M is rapidly upregulated in human monocytes pre-exposed to tumor cells and could be involved in deactivation of tumor-infiltrating monocytes mediated by tumor cells. PMID: 15728517
26. These findings indicate that IRAK-M selectively attenuates p38 activation and inhibits innate immunity through stabilizing MKP-1. PMID: 17379480
27. IRAK-M is involved in the pathogenesis of early-onset persistent asthma. PMID: 17503328
28. no evidence to suggest association between inflammatory bowel disease, Crohn's disease (CD), ulcerative colitis (UC) or subsets of CD & UC and IRAK-M; an interaction was found between IRAK-M and CARD15 in UC patients PMID: 17558906
29. LPS tolerance in human endotoxemia models is associated with IRAK-M up-regulation. PMID: 17982103
30. Porphyromonas gingivalis lipopolysaccharide upregulates IRAK-M in macrophages. PMID: 18156187
31. observed striking up-regulation of IRAK-M in monocytes, but without concomitant proinflammatory cytokine production PMID: 18354163
32. Analysis of single single nucleotide polymorphisms and haplotypes did not reveal a significant association between polymorphisms in the IRAK-M gene and atopic dermatitis in this cohort. PMID: 19013233
33. Immunosuppression in sepsis caused by B. pseudomallei is associated with an upregulation of IRAK-M and an indicator of poor outcome. PMID: 19114913
34. IRAK-M is a major mediator of globular adiponectin-induced endotoxin tolerance in primary macrophages PMID: 19414798
35. Nine SNPs distributed across eight genetic regions (ALOX5, IRAK3, ITGB2, NCF2, NFKB1, SELP, SOD1, and STAT1) were associated with risk of glioma with P value of <0.01. PMID: 19423540
36. inhibition of LPS-induced NFKB and ERK activation by acute alcohol leads to hyporesponsiveness of monocytes to LPS due to increased IRAK-M; chronic alcohol sensitizes monocytes to LPS through decreased IRAK-M expression and activation of NFKB and ERK PMID: 19561104

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HGNC: 17020

OMIM: 604459

KEGG: hsa:11213

STRING: 9606.ENSP00000261233

UniGene: Hs.369265