Recombinant Human Interleukin-18 receptor 1 (IL18R1), partial

Code CSB-YP623807HU
MSDS
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Source Yeast
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Code CSB-EP623807HU
MSDS
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Source E.coli
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Code CSB-EP623807HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP623807HU
MSDS
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Source Baculovirus
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Code CSB-MP623807HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Uniprot No.
Alternative Names
CD218 antigen-like family member A; CD218a; CDw218a; CDw218a antigen; IL 1Rrp; IL-18R-1; IL-18R1; IL-1Rrp; IL1 receptor related protein; IL1 receptor-related protein; IL18R_HUMAN; IL18R1; IL18RA; Il18ralpha; IL1R-rp; IL1RRP; Interleukin 18 receptor 1 ; Interleukin 18 receptor, alpha chain; Interleukin-18 receptor 1
Species
Homo sapiens (Human)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Within the IL18 receptor complex, responsible for the binding of the proinflammatory cytokine IL18, but not IL1A nor IL1B. Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells. Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3.
Gene References into Functions
  1. IL-18, IL-18R and IL-18BP expression in eosinophil are involved in the inflammatory reaction of asthma. PMID: 28395725
  2. IL18R1 rs1035130 may be associated with schizophrenia. PMID: 26736035
  3. IL-18 and IL-18R polymorphisms may contribute to the development and lymph node metastasis of PTC. PMID: 26600055
  4. strong evidence that IL-18 and IL18Ralpha have important functions in the pathogenesis of allergic asthma PMID: 26561030
  5. PDGFB and IL18R1 represent plausible candidates for studying the pathophysiology of these disorders in the context of TLR4 activation PMID: 25327457
  6. The architecture of the IL-18 receptor second domain (D2) is unique among the other IL-1R family members, which presumably distinguishes them from the IL-1 receptors that exhibit a more promiscuous ligand recognition mode. PMID: 25500532
  7. polymorphisms in the interleukin 18 receptor 1 gene and tuberculosis susceptibility among Chinese PMID: 25360588
  8. IL-37 requires the receptors IL-18Ralpha and IL-1R8 to carry out its multifaceted anti-inflammatory program upon innate signal transduction. PMID: 25729923
  9. There was no association between the rs917997 in IL18R gene and rs187238 in IL18 gene polymorphisms and risk for non-Hodgkin's malignant lymphomas in Novosibirsk population. PMID: 24909718
  10. IL-18, IL-18BP, and IL-18R may have roles in the pathogenesis of epithelial ovarian carcinoma PMID: 24963217
  11. IL-18R downregulates IFN-alpha production by activation-induced splicing of IL-18Ralpha into 2 isoforms: the full-length receptor (IL-18Ralpha1) and a novel, truncated variant (IL-18Ralpha2), a competitive molecular decoy inhibiting canonical IL-18Ralpha1/IL-18Rbeta signaling. PMID: 25170117
  12. structural basis for the specific recognition of IL-18 by its alpha receptor PMID: 25261253
  13. increased levels of soluble IL-18Ralpha complex in serum may also exert an antagonistic effect in vivo and play an important role in the inflammatory process in allergic asthma. PMID: 23963474
  14. Association between single nucleotide polymorphisms in the IL18R1, IL18 and interferon-gamma genes and smallpox vaccine induced adaptive immunity. PMID: 23901078
  15. Our study reveals the important role of IL12/IL18-mediated transcriptional regulation of IFN-gamma production in leprosy. PMID: 23103228
  16. Genetic variation in the promoter region of IL18, but not IL18R1, may be associated with knee osteoarthritis. PMID: 22136483
  17. The soluble IL-18Ralpha complex could be a potentially useful biomarker for the diagnosis of rheumatoid arthritis PMID: 21435242
  18. IL18 and its receptor may play an important role in the pathogenesis of allergic asthma. PMID: 21965503
  19. IL18 and IL18R1 genes as plausible genes regulating the humoral immune response to smallpox vaccine in both Caucasians and African Americans. PMID: 21742843
  20. The levels of plasma IL-18 and IL-18R on CD3(+) lymphocytes were significantly increased in active phase immune thrombocytopenia than in remission phase and controls. PMID: 19954659
  21. Report increased expression of IL18R1 in multiple sclerosis but did not find evidence of a genetic association with SNPs. PMID: 20354066
  22. These data suggest a role for IL-1F family members in psoriasis. PMID: 20833839
  23. IL-18 and IL-18Ralpha might upregulate the expression of Th1-cytokines in immune thrombocytopenia patients. PMID: 20627039
  24. Interleukin-18 receptor expression may possibly be responsible for the pathologic process of adenomyosis. PMID: 19394601
  25. These results demonstrate how IL-18 activity is regulated by TNFalpha and TGF-beta1, and how IFNgamma production through regulation of IL-18 receptor and T-bet expression. PMID: 19879772
  26. Expression of the IL-18 receptor is demonstrated on dendritic cells (DC) in peripheral blood and epidermis; on monocyte-derived DC its expression is up-regulated by interferon-gamma. PMID: 14662834
  27. The biologically active IL-8R complex requires the membrane-proximal third immunoglobulin-like domain in IL-18Ralpha for formation of IL-18R ternary complex as well as for signaling involved in IL-18-induced interferon-gamma in natural killer cells. PMID: 14662859
  28. IL-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP in Jurkat cells. PMID: 14734551
  29. the promoter region of IL-18 receptor has two novel single nucleotide polymorphisms PMID: 15009178
  30. Thus, our results identified a functional region in the IL-1R AcP required for the recruitment and activation of PI 3-kinase. PMID: 15044087
  31. Transfection of C33A cervical cancer cells with the IL-18 receptor induced IL-18 expression, and enhanced intracellular reactive oxygen species and Fas expression. PMID: 15202785
  32. review of structure, function and tissue distribution of IL-18R [review] PMID: 15323361
  33. The overexpression of IL-18Ralpha predominantly by CD4+ T cells in sarcoidosis emphasizes crucial roles played by T-helper type 1 cells in the IL-18/IL-18Ralpha system in sarcoidosis PMID: 16236915
  34. Two IFN-gammaR2 chains interact through species-specific determinants in their extracellular domains. Finally, these determinants also participate in the interaction of IFN-gammaR2 with IFN-gammaR1. PMID: 16467876
  35. our data show that variola virus IL-18BP prevents IL-18 from binding to IL-18R by interacting with three residues that are part of the binding site for hIL-18Ralpha. PMID: 16979683
  36. A twofold increase in the percentage of CD4-resting T cells expressing IL-12Rbeta1 and IL-18Ralpha from HIV-1-infected patients; deregulation of the IL-12 and IL-18 pathways may play a role in the immunopathogenesis of HIV-1 infection. PMID: 17403771
  37. There is a significant association between polymorphisms of interleukin 18 receptor 1 and asthma. PMID: 18382474
  38. Our analysis suggests that the variability of IL18R1 genes is unlikely to contribute to modulate the risk of cardiovascular disease PMID: 19473509

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Subcellular Location
Membrane; Single-pass type I membrane protein.
Protein Families
Interleukin-1 receptor family
Tissue Specificity
Highly expressed in leukocytes, spleen, lung. Also expressed, but at lower levels, in liver, small intestine, colon, prostate, thymus, placenta, and heart. Specifically coexpressed with IL18R1 in Th1 cells.
Database Links

HGNC: 5988

OMIM: 604494

KEGG: hsa:8809

STRING: 9606.ENSP00000233957

UniGene: Hs.469521

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