Recombinant Human Limbic system-associated membrane protein (LSAMP)

Code CSB-YP013197HU
MSDS
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Source Yeast
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Code CSB-EP013197HU
MSDS
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Source E.coli
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Code CSB-EP013197HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP013197HU
MSDS
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Source Baculovirus
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Code CSB-MP013197HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
LSAMP
Uniprot No.
Alternative Names
IgLON family member 3; IGLON3; Lam; LAMP; Limbic system associated membrane protein ; Limbic system associated membrane protein precursor ; Limbic system-associated membrane protein; LSAMP; LSAMP_HUMAN
Species
Homo sapiens (Human)
Expression Region
29-315
Target Protein Sequence
VR SVDFNRGTDN ITVRQGDTAI LRCVVEDKNS KVAWLNRSGI IFAGHDKWSL DPRVELEKRH SLEYSLRIQK VDVYDEGSYT CSVQTQHEPK TSQVYLIVQV PPKISNISSD VTVNEGSNVT LVCMANGRPE PVITWRHLTP TGREFEGEEE YLEILGITRE QSGKYECKAA NEVSSADVKQ VKVTVNYPPT ITESKSNEAT TGRQASLKCE ASAVPAPDFE WYRDDTRINS ANGLEIKSTE GQSSLTVTNV TEEHYGNYTC VAANKLGVTN ASLVLFRPGS VRGIN
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Mediates selective neuronal growth and axon targeting. Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. Essential for normal growth of the hyppocampal mossy fiber projection.
Gene References into Functions
  1. We detected African-specific SNPs at ZNF649 and LSAMP, with associations of genome-wide significance for ulcerative colitis. PMID: 27693347
  2. A novel genomic alteration of LSAMP associates with aggressive prostate cancer in African American men PMID: 26844274
  3. The results showed significant allelic and haplotypic associations between LSAMP gene and schizophrenia. PMID: 24491686
  4. The tumor suppressor function of LSAMP is most likely exerted by reducing the proliferation rate of the tumor cells, possibly by indirectly upregulating one or more of the genes HES1, CTAG2 or KLF10. PMID: 24885297
  5. This study presents the first evidence of a possible role of LSAMP gene in mood and anxiety disorders in humans. PMID: 22892717
  6. proteomic assessments of membrane microdomains in prefrontal cortex and validation in two brain series, strongly implicates LAMP, STXBP1 and BASP1 in schizophreina and supports the view of a neuritic and synaptic dysfunction in the neuropathology PMID: 18268500
  7. Single nucleotide polymorphisms of LSAMP is associated with the pathogenesis of coronary artery disease. PMID: 18318786
  8. LSAMP might play a role in pathoaetiology of suicidal behaviour but further studies are needed to understand its exact contribution PMID: 18433483
  9. results show that LSAMP is a novel candidate tumor suppressor gene in osteosarcomas PMID: 19441093
  10. Identification of chromosomal aberrations associated with disease progression and a novel 3q13.31 deletion involving LSAMP gene in osteosarcoma. PMID: 19724913

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Subcellular Location
Cell membrane; Lipid-anchor, GPI-anchor.
Protein Families
Immunoglobulin superfamily, IgLON family
Tissue Specificity
Expressed on limbic neurons and fiber tracts as well as in single layers of the superior colliculus, spinal chord and cerebellum.
Database Links

HGNC: 6705

OMIM: 603241

KEGG: hsa:4045

UniGene: Hs.26409

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