Recombinant Human Low molecular weight phosphotyrosine protein phosphatase(ACP1)

Code CSB-EP001176HU
Size US$1726
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

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Product Details

Purity Greater than 90% as determined by SDS-PAGE.
Target Names ACP1
Uniprot No. P24666
Research Area Cell Biology
Alternative Names Acid phosphatase 1 soluble; Acid phosphatase of erythrocyte ; ACP1; Adipocyte acid phosphatase; Cytoplasmic phosphotyrosyl protein phosphatase; HAAP; LMW-PTP; LMW-PTPase; Low molecular weight cytosolic acid phosphatase; Low molecular weight phosphotyrosine protein phosphatase; PAP1; PAP2; phosphatase; acid; of erythrocyte; PPAC_HUMAN; Protein tyrosine phosphatase; PTPase; Purple acid phosphatase; Red cell acid phosphatase 1; testicular secretory protein Li 37
Species Homo sapiens (Human)
Source E.coli
Expression Region 1-158aa
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Mol. Weight 45.0kDa
Protein Length Full Length of Isoform 1
Tag Info N-terminal GST-tagged
Form Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

Target Data

Function Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity.
Gene References into Functions
  1. ACP1 may have an important role in regulation of the multiple systems associated with suicide. PMID: 28668716
  2. Conditioned medium from MDA-MB-231 breast cancer cells with total knockdown of LMW-PTP, but not of slow isoform LMW-PTP, significantly reduced osteoclast differentiation of RAW 264.7 cells. PMID: 29187443
  3. results confirm the role of TPH1, TPH2, 5HT2A, CRHR1 and ACP1 variants in the risk of suicidal behavior. PMID: 27479537
  4. These data support that PTPN22 1858C/T, PTPRJ 2965C/G and 1176 A/C polymorphisms and ACP1 A, B and C alleles are not associated with a higher risk of immune thrombocytopenia P in adults. PMID: 27309885
  5. The LMW-PTP slow isoform can be an important protein in bone metastatic disease, with a fundamental role in the interplay between tumor cells and osteoclasts, through the regulation of Src activity and IL-8 secretion. PMID: 27127127
  6. Overexpression of LMWPTP in prostate cancer confers a malignant phenotype with worse clinical outcome. PMID: 26159288
  7. ADA6, PTPN22 and ACP1 are involved in immune reactions: since endometriosis has an autoimmune component. PMID: 26216523
  8. LMPTP expression increases in end-stage heart failure in humans PMID: 26213100
  9. Suggest that hypermethylation of ACP1, BMP4, and TSPYL5 are common events in HCC and could be used as potentially detectable biomarkers in HCC tissues. PMID: 26386860
  10. the present study found that the ACP1*C allele, previously associated with an increased vulnerability to infectious/parasitic diseases may also be able to shape behavioral immune defenses by interaction with the level of E. PMID: 24933463
  11. Association of an increased risk of coronary artery disease, especially in females, with ACP1 polymorphisms. PMID: 25846885
  12. ACP1 knockdown attenuates effects of osmotic stress in HaCaT cells, mainly in the status of Src kinase, Rac and STAT5 phosphorylation and activity. PMID: 25781955
  13. The rs3828329 of ACP1 gene is also a risk factor of CAD in Han Chinese females aged 65 years and older. PMID: 25123136
  14. ACP1 polymorphism is associated with type 1 diabetes mellitus. PMID: 25125338
  15. In ACP1 *B/*C genotype, which shows the highest enzymatic activity, spermatic concentration is significantly lower and atypical spermatozoa are significantly more frequent as compared to other ACP1 genotypes. PMID: 23278455
  16. In Class 3 people the combination of high ACP f-isozyme concentration and the ADA*2 allele, lowers the rate of glycolysis that may reduce the amount of metabolic calories and activates Sirtuin genes that protect cells against age-related diseases. PMID: 23959645
  17. certain genotypes of ACP1 associated with high phosphatase activity may increase the T-cell response to PF4-heparin complexes, with higher levels of circulating antibodies PMID: 23621699
  18. A significant increase of PTPN22 *T allele in endometriosis is observed in women carrying ACP1*C allele, in women carrying p53 codon 72 *Pro allele PMID: 23453606
  19. clarification of the importance of ACP1 in carcinogenesis through the analysis of LMW-PTP interaction with different substrates [review] PMID: 23584899
  20. The data suggest an interaction between p53 codon 72 and ACP wherein a positive effect of the p53 *Pro allele on susceptibility to coronary artery disease occurs. PMID: 23197232
  21. mRNA expression of the slow isoform was increased in breast cancer and that of the fast isoform was reduced in breast cancer. PMID: 23645747
  22. balanced redox-state is required for VEGF to facilitate reversible S-glutathionylation of LMW-PTP, FAK activation and endothelial cell migration PMID: 22854047
  23. lack of association with inflammatory bowel disease in Spanish patients PMID: 22428720
  24. There is a significant association between acid phosphatase locus 1 (ACP(1) and cancer grade, mainly due to ACP(1) genotypes carrying the *C allele that are much less represented in patients with low grade when compared with those with high grade. PMID: 22692348
  25. the ACP1 protein is a tyrosine phosphatase that influences Wnt signaling, a pathway regulated by lithium, making ACP1 a functional candidate for involvement in the phenotype. PMID: 21423239
  26. Data indicate that ACP1 rs11553742*T with increased susceptibility in systemic lupus erythematosus (SLE) patients. PMID: 22064183
  27. Gain of the telomeric region 2p25.3 harboring the ACP1 gene is common in CLL (25%, 44 of 178 cases). PMID: 22035742
  28. the ACP1*C allele influences the risk of cardiovascular disease events in patients with rheumatoid arthritis. PMID: 21767392
  29. Although both variants dephosphorylate the EPHA2 receptor, the rate and specificity of dephosphorylation for specific tyrosines are different for ACP1 and human cytoplasmic protein tyrosine phosphatase-B. PMID: 21538645
  30. investigated hypothesis that favism is caused by toxic Vicia faba substances, which in some ACP1 phenotypes cause increased phosphorylation and thus increased glycolysis, with strong reduction in reduced glutathione production, resulting in hemolysis PMID: 21644204
  31. In overweight women (BMI > 25), the proportion of low activity ACP1 phenotypes is much lower in type 1 diabetes than in gestational diabetes and in healthy females. PMID: 19855922
  32. the correlation between blood glucose and glycated Hb in relation to AK1 and ACP1 polymorphism was studied. PMID: 20152999
  33. Type 1 diabetes subjects show a highly significant increase of ACP1*A/ADA1*2 gametic type compared with healthy subjects from the same population (P = 0.003). PMID: 20805743
  34. association with coronary artery disease evident only in diabetic subjects and dependent on female gender PMID: 20581655
  35. A significant interaction between ACP1 and ADA1 concerning susceptibility to type 1 diabetes, was revealed. PMID: 19789510
  36. ACP1 is associated with allergy PMID: 12100313
  37. Association of the ACP1 genotype with metabolic parameters upon initial diagnosis of type 1 diabetes. PMID: 12640337
  38. LMW-PTP has a role in immunological synapse establishment and stabilization through the negative control of FAK activity and of cell surface receptor redistribution PMID: 12815062
  39. The analysis involved the data on nine polymorphic codominant loci: HP, GC, TF, PI, PGM1, GLO1, C3, ACP1, and ESD. The loci were selected by significance of differences in genotype frequencies between tuberculosis patients and healthy controls PMID: 12942785
  40. We show that the association of STAT5 and LMW-PTP does not exclusively involve the phosphatase active site and phosphotyrosine residue of STAT5. PMID: 14637146
  41. acid phosphatase 1 contributes to the clinical manifestations of type 2 diabetes and probably also have a marginal influence on susceptibility to the disease PMID: 15281007
  42. complex interaction among maternal age, sex of infant and ACP1 concerning age at diagnosis of diabetes PMID: 15586390
  43. Finds ACP1*C is a recessively deleterious allele that reduces viability during early life stages and is not maintained by overdominant selection in European populations. PMID: 15974295
  44. Significant correlations between LMW-PTP overexpression and the most common clinical-pathological features of cancers exist. In colon cancer and neuroblastoma increased total LMW-PTP mRNA expression correlates with unfavourable outcome. PMID: 16036221
  45. Crystal structure of the second human low molecular weight PTPase isoenzyme provides the opportunity to examine the structural basis of different substrate and inhibitor/activator responses. PMID: 16253994
  46. mother/newborn pairs: ACP1 (acid phosphatase 1)distribution has fewer pairs with maternal low ACP1 S isoform and infant high S isoform concentration;Recurrent spontaneous abortion couples show wife low S isoform and husband high S isoform concentration PMID: 16762482
  47. GRX plays an important role in PDGF-BB-dependent cell proliferation by regulating the redox state of LMW-PTP PMID: 16893901
  48. Among newborns carrying the ACP1C allele there is an increase of Sex Ratio among the offspring of smoking mothers relative to non-smoking mothers. PMID: 16973312
  49. Human recombinant LMWPTP-A displayed an RN5Pase activity that was higher than its tyrosine phosphatase activity, indicating that this phosphatase may participate in protein deglycation, a new form of protein repair. PMID: 17472574
  50. results suggest a cooperative effect of ADA and ACP1 genetic polymorphism on the susceptibility to repeated spontaneous abortion and to some of its clinical characteristics PMID: 17565542
  51. Women homozygous for haptoglobin with low ACP1 activity are more likely to conceive in the first part of the year. Women heterozygous for haptoglobin with medium-high ACP1 activity are more likely to conceive in the last part of the year. PMID: 17678914
  52. There is a significant negative correlation between the intensity of skin test reaction and the ACP1 *B/*C genotype in allergic individuals. PMID: 17703100
  53. The increase of fast isozyme concentration increased the invasive capacity of cancer cells, whereas a decrease of slow isozyme concentration in cancer did not cause growth inhibition and so resulted in cancer cell proliferation. PMID: 18262048
  54. These findings suggest that carriers of high activity ACP1 genotypes are more susceptible to endometriosis but less susceptible to allergic manifestations than carriers of other ACP1 genotypes. PMID: 18490013
  55. Highly significant differences in birth weight-placental weight correlations were observed among acid phosphatase locus 1 phenotypes. PMID: 18768081
  56. There is an increase of the *B/*B genotype (high F isoform) & a much more marked decrease of genotypes with the high S isoform in colon cancer, compared with controls. PMID: 18786445
  57. High concontration of the ACP1 F isoform may negatively regulate cell proliferation and growth of leiomyomas through dephosphorylation of the PDGF receptor. PMID: 18992867
  58. Present in adipocytes, this protein may have a specific role in the regulation of quantity of adipose tissue. PMID: 19217450
  59. ACP1 may be involved in susceptibility to coronary artery disease PMID: 19246900
  60. The present data suggest an epistatic action of ACP1 concerning the effect of Hp on the susceptibility to convulsive disorders. PMID: 19569002
  61. A possible protective effect of ACP1 genotype against cardiovascular risk factors was observed in this study PMID: 19570551
  62. Variation in ACP1 is associated with fasting insulin and insulin sensitivity in a sex-specific manner. There is a sex-specific effect of variation in ACP1 to alter insulin signaling. PMID: 19622628

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Subcellular Location Cytoplasm
Protein Families Low molecular weight phosphotyrosine protein phosphatase family
Tissue Specificity T-lymphocytes express only isoform 2.
Database Links

HGNC: 122

OMIM: 171500

KEGG: hsa:52

STRING: 9606.ENSP00000272065

UniGene: Hs.558296

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