Recombinant Human Matrix metalloproteinase-26 (MMP26)

1. MMP26 is overexpressed in prostatic neoplasms patients, and can serve as a serum disease biomarker. PMID: 29270749
2. The luciferase report assay demonstrated that MMP26 is a target gene of miR-125b. And the expression profile of MMP26 showed an inverse relationship with miR-125b in vivo and in vitro. PMID: 27143441
3. MMP26+CXCR4+ cells may be circulating tumor cells in hepatocellular carcinoma. PMID: 26279442
4. We found that only inhibition of JNK significantly decreased the activation of MMP26 in response to FGF1 stimulation, suggesting that activation of FGFR1 signaling may activate JNK to activate MMP26 in non-small-cell lung cancer PMID: 25566961
5. Overexpression of MMP26 in SW1353 cells increased cell invasiveness, while inhibition of MMP26 decreased cell invasiveness. PMID: 25262277
6. The binding of MMP-26 to GDF15 was responsible for the processing and maturation of pro-GDF15, and the process was dependent on enzymatic activity of MMP-26. In human placental trophoblast cells, MMP-26 could facilitate the pro-apoptotic effect of GDF15. PMID: 25093616
7. matrilysin-2 was an independent prognostic marker for patients with colorectal cancer PMID: 24318970
8. These results demonstrate that the HOXA10-mediated expression of MMP-26 promotes embryo adhesion during the process of embryonic implantation. PMID: 24565841
9. The MMP-26 promoter region contains a putative ER response element. PMID: 23754174
10. expression of MMP-26 protein was predominantly located in pre- and early-invasive areas suggesting MMP-26 expression as an early event in promoting GM-CSF dependent tumor invasion. PMID: 23634280
11. Molecular analyses showed significant downregulation of expression of MMP-26 (p=0.03), and significant 9.8-fold upregulation of TGF-beta (p=0.01) in more degenerated discs vs. healthier discs. PMID: 21945733
12. MMP-26 plays an important role in local invasion at least in part through coordination with MMP-9. PMID: 21805034
13. direct association observed between morphological scores of malignancy and MMP immunoreactivity, with the association being significant for MMP-26. present results demonstrate important role of MMPs in development of SCCs of lower lip and tongue. PMID: 21255765
14. MMP-26 expression may be associated with multiple human carcinomas. MMP-26 may also contribute to smooth muscle function in the human prostate and cardiovascular system. PMID: 19895737
15. role of these proteins in the process of invasion and metastasis cannot be ruled out since their presence is more marked along the tumor invasion front compared to more central areas of squamous cell carcinoma of the tongue PMID: 20491537
16. GnRH I and II could up-regulate MMP-26 expression through the JNK signaling pathway in human trophoblast-like/trophoblast cells. PMID: 20074375
17. MMP-26 contributes to tumor cell invasion, migration and angiogenesis PMID: 19956866
18. MMP-26 expression in stroma is associated with larger Merkel cell carcinoma with poor prognosis. PMID: 19921252
19. can cleave all subclasses of igG at a specific conserved site PMID: 11841844
20. role of histidine(81) in mechanism of activation PMID: 11889136
21. Promoter characterization of the novel human matrix metalloproteinase-26 gene: regulation by the T-cell factor-4 implies specific expression of the gene in cancer cells of epithelial origin. PMID: 11931652
22. substrate specificity and protein cleavage sites PMID: 12119297
23. Details of cleavage of pro-MMP-9 by MMP-26, facilitating the efficient cleavage of fibronectin by MMP-9, and promoting invasiveness of ARCaP cells across fibronectin or type IV collagen PMID: 12586837
24. Present throughout menstrual cycle. Elevated during early to mid-luteal phase. Elevations in users of levonorgestrel implants experiencing irregular uterine bleeding. Seems to play role in hormonal regulation and endometrial tissue remodeling. PMID: 12969699
25. distinguish shallow, intermediate, and deep S1' pocket characteristics PMID: 14532275
26. MMP-26 was colocalized with MMP-9, TIMP-2, and TIMP-4 in breast cancer cells. PMID: 14744773
27. Results suggest a functional relationship between TIMP-4 mRNA and MMP-26 mRNA, and possibly a role in human implantation. PMID: 15273280
28. Matrilysin-2 overexpression is associated with tumor progression and activation of MMP-9 in esophageal squamous cell carcinoma PMID: 15333466
29. The expression patterns of MMP26 in human placenta suggests complicated roles for MMP26 during the processes of placentation and hematopoiesis PMID: 15601912
30. During esophageal tumorigenesis, MMP-21 and MMP-26 have different, unique expression patterns. PMID: 16641547
31. Maximal expression of MMP-26, in the early and mid-secretory phase suggests its role during implantation and results show it is stored in epithelial cells, is not released spontaneously, and is controlled by TIMP-4 in both stroma and uterine fluid. PMID: 16809379
32. Results indicate that MMP-26 and TIMP-4 may play an integral role during the conversion of high-grade prostatic intraepithelial neoplasia to invasive cancer and may also serve as markers for early prostate cancer diagnosis. PMID: 16940965
33. results suggest that MMP-21 and MMP-26 are not only associated with cancer but may be important in connective tissue remodelling and pathobiology of various benign skin disorde PMID: 16984259
34. A human breast cancer cell linetransfected with wild-type MMP-26 cDNA showed a calcium-dependent invasive potential when compared with controls. PMID: 17176253
35. The putative role of MMP-26 as a marker of metastasesin pancreatic cancer warrants further studies PMID: 17873896
36. expression of transmembrane 4 superfamily member 4 (TM4SF4) and matrix metalloproteinase 26 (MMP26) was found to be significantly decreased during the implantation window in patients with polycystic ovary syndrome. PMID: 18765015
37. MMP-26 may be served as a tumor marker in monitoring progression and predicting prognosis of non-small cell lung cancer. PMID: 19448419
38. MMP-26 and MMP-9 may contribute to the more aggressive behavior of squamous cell carcinomas in organ transplant recipients PMID: 19674198

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HGNC: 14249

OMIM: 605470

KEGG: hsa:56547

STRING: 9606.ENSP00000300762

UniGene: Hs.204732