Recombinant Human Meteorin(METRN)

Code CSB-EP892322HU
Size US$2466
Image
  • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP892322HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) METRN.
  • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP892322HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) METRN.
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Product Details

Purity Greater than 85% as determined by SDS-PAGE.
Target Names METRN
Uniprot No. Q9UJH8
Research Area Neuroscience
Alternative Names C16orf23; c380A1.2; Meteorin; Meteorin precursor ; meteorin; glial cell differentiation regulator; Metrn; METRN_HUMAN; MGC2601
Species Homo sapiens (Human)
Source E.coli
Expression Region 24-293aa
Target Protein Sequence GYSEERCSWRGSGLTQEPGSVGQLALACAEGAVEWLYPAGALRLTLGGPDPRARPGIACLRPVRPFAGAQVFAERAGGALELLLAEGPGPAGGRCVRWGPRERRALFLQATPHQDISRRVAAFRFELREDGRPELPPQAHGLGVDGACRPCSDAELLLAACTSDFVIHGIIHGVTHDVELQESVITVVAARVLRQTPPLFQAGRSGDQGLTSIRTPLRCGVHPGPGTFLFMGWSRFGEARLGCAPRFQEFRRAYEAARAAHLHPCEVALH
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Mol. Weight 36.5 kDa
Protein Length Full Length of Mature Protein
Tag Info N-terminal 10xHis-tagged and C-terminal Myc-tagged
Form Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

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 Q&A
Q:

Regarding CSB-EP892322HU (all expression systems), I would like to know if in liquid form (Tris-based buffer, 50% glycerol) if this product is soluble in cell culture medium or is it lyophilic?
Please let me know if you have any additional questions.

A:
Thanks for your inquiry. Sorry, these are semi-customized proteins that we haven't expressed before. Regarding this protein, we provide the soluble expression for Yeast, Baculovirus and Mammalian cell expression systems,
as for the E.coli expression system, we will try our best to optimize the condition to ensure soluble expression, If it is expressed in inclusion bodies, it will be renatured, and eventually gunaratee we will provide soluble proteins.
So we can guarantee that all of the proteins will be provided in soluble form. As for the lyophilic, we have used the software (https://web.expasy.org/protparam/) to predict, the result is -0.134, it should be lyophilic.
Q:

We would like to know the instructions for solubilizing the protein? If you have this information.
Please let me know if you have any additional questions.

A:
Thanks for your inquiry. As for the the instructions for solubilizing the protein, we may try a series of conditions to optimize the expression, such as optimizing the codon, the vector, the culture temperature, the incubation time, the concentration of the inducer, etc., try to do the soluble expression but not 100% guarantee, if it is an inclusion body expression, it will be renatured and we can guarantee that we will eventually provide soluble protein.

Target Data

Function Involved in both glial cell differentiation and axonal network formation during neurogenesis. Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. Also induces axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia (By similarity).
Gene References into Functions
  1. The joint measurements of circulating METRN levels in the first trimester and systolic blood pressure and weight in the second trimester significantly increase the probabilities of predicting preeclampsia. PMID: 26121675
  2. Meteorin plays important roles in both glial cell differentiation and axonal network formation during neurogenesis. PMID: 15085178
Subcellular Location Secreted
Protein Families Meteorin family
Database Links

HGNC: 14151

OMIM: 610998

KEGG: hsa:79006

STRING: 9606.ENSP00000455068

UniGene: Hs.533772

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