Recombinant Human Mitochondrial inner membrane protein COX18 (COX18), partial

Code CSB-YP854071HU
MSDS
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Source Yeast
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Code CSB-EP854071HU
MSDS
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Source E.coli
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Code CSB-EP854071HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP854071HU
MSDS
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Source Baculovirus
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Code CSB-MP854071HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
COX18
Uniprot No.
Alternative Names
COX18; COX18 cytochrome c oxidase assembly homolog (S. cerevisiae); COX18_HUMAN; COX18Hs; Cox18Hs1 protein; Cox18Hs2 protein; Cox18Hs3 protein; Cytochrome c oxidase assembly homolog (S. cerevisiae); Cytochrome c oxidase assembly protein 18; FLJ38991; MGC126733; Mitochondrial COX18; Mitochondrial inner membrane protein COX18; OXA1L2
Species
Homo sapiens (Human)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Mitochondrial membrane insertase required for the translocation of the C-terminus of cytochrome c oxidase subunit II (MT-CO2/COX2) across the mitochondrial inner membrane. Plays a role in MT-CO2/COX2 maturation following the COX20-mediated stabilization of newly synthesized MT-CO2/COX2 protein and before the action of the metallochaperones SCO1/2. Essential for the assembly and stability of the mitochondrial respiratory chain complex IV (also known as cytochrome c oxidase).
Gene References into Functions
  1. COX20 stabilizes COX2 during insertion of its N-proximal transmembrane domain, and subsequently, COX18 transiently interacts with COX2 to promote translocation across the inner membrane of the COX2 C-tail that contains the apo-CuA site. The release of COX18 from this complex coincides with the binding of the SCO1-SCO2-COA6 copper metallation module to COX2-COX20 to finalize COX2 biogenesis. PMID: 28330871
  2. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 20819778
  3. Observational study of gene-disease association. (HuGE Navigator) PMID: 20877624
  4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
  5. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20200953
  6. COX18 mutations may be very rare or associated with other phenotypes than isolated COX deficiency in infancy. PMID: 19373256
  7. Both hCox18p and hCox19p present significant amino acid identity with the corresponding yeast polypeptides and reveal highly conserved functional domains. PMID: 16212937

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Subcellular Location
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein Families
OXA1/ALB3/YidC family
Database Links

HGNC: 26801

OMIM: 610428

KEGG: hsa:285521

STRING: 9606.ENSP00000295890

UniGene: Hs.356697

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