Recombinant Human Mitogen-activated protein kinase kinase kinase MLT (MLTK)

1. The ZAK rs3769201 and rs722864 may be functional susceptibility loci for lung cancer risk. PMID: 29071797
2. The expression of ZAKbeta is dependent on ZAKalpha expression, and ZAKbeta further enhances ZAKalpha expression and results in synergistic enhancement of apoptosis in osteosarcoma cells. PMID: 29654619
3. Gene set enrichment analysis disclosed a significant correlation between ZAK+ colorectal premalignant lesions and gene sets belonging to the MAPK/ERK and motility-related signaling pathways of the reactome database, strongly suggesting that ZAK induces such pro-tumoral reaction cascades in human cancers. PMID: 26522728
4. Recessive mutations in the kinase ZAK - novel cause of congenital myopathy. PMID: 27816943
5. ZAK is a key player in mammalian limb patterning in humans and mice. PMID: 26755636
6. ZAK kinase isoform TV1 is preferentially upregulated in gastric tumours and cell lines relative to normal samples. This pattern is also observed in colorectal, bladder and breast cancers. PMID: 24807215
7. The long non-coding RNA URHC promotes cell proliferation and inhibits apoptosis by repressing ZAK expression through inactivation of the ERK/MAPK pathway. PMID: 25013376
8. we report that sorafenib suppresses UV-induced apoptosis specifically by inhibiting c-jun-NH(2)-kinase (JNK) activation through the off-target inhibition of leucine zipper and sterile alpha motif-containing kinase (ZAK) PMID: 24170769
9. MRK is a novel RhoC effector that controls LPA-stimulated cell invasion at least in part by regulating myosin dynamics, ERK and p38 PMID: 23319595
10. The genes identified KTN1, ROCK1, and ZAK may be responsible for loss of cellular homeostasis in giant cells tumors of bone PMID: 21305317
11. decrease of lung cancer cell proliferation by ZAK may involve the ERK and JNK pathways via an AP-1 transcription factor. PMID: 20331627
12. In this study, by applying a novel method, we have identified the phosphorylation sites in human MSK1 mitogen- and stress-activated protein kinase 1, and show that MRK-beta could also activate MSK1 through direct interaction. PMID: 20408143
13. Results suggest that ZAK might play a role as an upstream signal to suppress the ZZaPK function and decrease E2F expression. PMID: 12535642
14. Data show that in response to radiation, MRK controls two independent pathways: the Chk2-Cdc25A pathway leading to cell cycle arrest and the p38gamma MAPK pathway PMID: 15342622
15. Results suggest that a ZAK mediates TGF-beta-induced cardiac hypertrophic growth via a novel TGF-beta signaling pathway. PMID: 15465036
16. ZAK induces characteristic hypertrophic growth features, including increased cell size, elevated atrial natriuretic factor expression, and increased actin fiber organization PMID: 15485649
17. Mixed lineage kinase 7 (MLK7), a splice variant of the ZAK gene, encodes an isoform which is the MAPKKK required for modulation of the stress-activated MAPKs downstream of anisomycin and UV stimulation. PMID: 15737997
18. data demonstrate that a ZAK isoform(s) is the MAP3Kinase that transduces the ribotoxic stress response PMID: 18331592

Show More

Hide All

HGNC: 17797

OMIM: 609479

KEGG: hsa:51776

STRING: 9606.ENSP00000364361

UniGene: Hs.444451