Recombinant Human Myb-related protein A (MYBL1)

Code CSB-YP015263HU
MSDS
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Source Yeast
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Code CSB-EP015263HU
MSDS
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Source E.coli
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Code CSB-EP015263HU-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP015263HU
MSDS
Size Pls inquire
Source Baculovirus
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Code CSB-MP015263HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
MYBL1
Uniprot No.
Alternative Names
A-Myb; AMYB; MGC120059; MGC120061; Myb related protein A; Myb-like protein 1; Myb-related protein A; MYBA_HUMAN; MYBL1
Species
Homo sapiens (Human)
Expression Region
1-752
Target Protein Sequence
MAKRSRSEDE DDDLQYADHD YEVPQQKGLK KLWNRVKWTR DEDDKLKKLV EQHGTDDWTL IASHLQNRSD FQCQHRWQKV LNPELIKGPW TKEEDQRVIE LVQKYGPKRW SLIAKHLKGR IGKQCRERWH NHLNPEVKKS SWTEEEDRII YEAHKRLGNR WAEIAKLLPG RTDNSIKNHW NSTMRRKVEQ EGYLQDGIKS ERSSSKLQHK PCAAMDHMQT QNQFYIPVQI PGYQYVSPEG NCIEHVQPTS AFIQQPFIDE DPDKEKKIKE LEMLLMSAEN EVRRKRIPSQ PGSFSSWSGS FLMDDNMSNT LNSLDEHTSE FYSMDENQPV SAQQNSPTKF LAVEANAVLS SLQTIPEFAE TLELIESDPV AWSDVTSFDI SDAAASPIKS TPVKLMRIQH NEGAMECQFN VSLVLEGKKN TCNGGNSEAV PLTSPNIAKF STPPAILRKK RKMRVGHSPG SELRDGSLND GGNMALKHTP LKTLPFSPSQ FFNTCPGNEQ LNIENPSFTS TPICGQKALI TTPLHKETTP KDQKENVGFR TPTIRRSILG TTPRTPTPFK NALAAQEKKY GPLKIVSQPL AFLEEDIREV LKEETGTDLF LKEEDEPAYK SCKQENTASG KKVRKSLVLD NWEKEESGTQ LLTEDISDMQ SENRFTTSLL MIPLLEIHDN RCNLIPEKQD INSTNKTYTL TKKKPNPNTS KVVKLEKNLQ SNCEWETVVY GKTEDQLIMT EQARRYLSTY TATSSTSRAL IL
Protein Length
Full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Transcription factor that specifically recognizes the sequence 5'-YAAC[GT]G-3'. Acts as a master regulator of male meiosis by promoting expression of piRNAs: activates expression of both piRNA precursor RNAs and expression of protein-coding genes involved in piRNA metabolism. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity. Transcriptional activator of SOX30.
Gene References into Functions
  1. Low MYBL1 expression is associated with colon cancer. PMID: 28096468
  2. Our study defines new molecular subclasses of ACC characterized by MYBL1 rearrangements and 5'-NFIB gene fusions. PMID: 26631609
  3. Thus, the LIMD1-MYBL1 Index had considerable clinical value for DLBCL subtype classification and prognosis. PMID: 25940947
  4. analysis of genetic alterations in MYBL1 in diffuse pediatric low-grade gliomas PMID: 23633565
Subcellular Location
Nucleus.
Tissue Specificity
Expressed in a variety of lymphoid and solid tumor lines cultured in vitro.
Database Links

HGNC: 7547

OMIM: 159405

KEGG: hsa:4603

STRING: 9606.ENSP00000429633

UniGene: Hs.445898

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