Recombinant Human NFATC2-interacting protein (NFATC2IP)

Code CSB-YP822758HU
MSDS
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Source Yeast
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Code CSB-EP822758HU
MSDS
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Source E.coli
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Code CSB-EP822758HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP822758HU
MSDS
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Source Baculovirus
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Code CSB-MP822758HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
NFATC2IP
Uniprot No.
Alternative Names
45 kDa NF-AT-interacting protein; 45 kDa NFAT-interacting protein; cytoplasmic 2-interacting protein; ESC2; NF2IP_HUMAN; NFAT-interacting protein, 45-KD; NFATC2-interacting protein; Nfatc2ip; NIP45; Nuclear factor of activated T-cells; Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein; RAD60
Species
Homo sapiens (Human)
Expression Region
1-419
Target Protein Sequence
MAEPVGKRGR WSGGSGAGRG GRGGWGGRGR RPRAQRSPSR GTLDVVSVDL VTDSDEEILE VATARGAADE VEVEPPEPPG PVASRDNSNS DSEGEDRRPA GPPREPVRRR RRLVLDPGEA PLVPVYSGKV KSSLRLIPDD LSLLKLYPPG DEEEAELADS SGLYHEGSPS PGSPWKTKLR TKDKEEKKKT EFLDLDNSPL SPPSPRTKSR THTRALKKLS EVNKRLQDLR SCLSPKPPQG QEQQGQEDEV VLVEGPTLPE TPRLFPLKIR CRADLVRLPL RMSEPLQSVV DHMATHLGVS PSRILLLFGE TELSPTATPR TLKLGVADII DCVVLTSSPE ATETSQQLQL RVQGKEKHQT LEVSLSRDSP LKTLMSHYEE AMGLSGRKLS FFFDGTKLSG RELPADLGME SGDLIEVWG
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression. Down-regulates formation of poly-SUMO chains by UBE2I/UBC9.
Gene References into Functions
  1. ZBTB25 functions as a negative regulator of nuclear factor of activated T cells (NF-AT) activation, such that RNA interference mediated knockdown resulted in enhanced activation of target genes. PMID: 20410506
Subcellular Location
Nucleus. Cytoplasm.
Database Links

HGNC: 25906

OMIM: 614525

KEGG: hsa:84901

STRING: 9606.ENSP00000324792

UniGene: Hs.513470

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